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304 Cards in this Set

  • Front
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chloramphenicol
bone marrow toxicity
chloramphenicol
inhibits hepatic oxidases
chloramphenicol
broad spectrum- G+ and G-(N menin, H inf, Salmonella, bacteroides)
chloramphenicol
grey baby syn
bacteroides
chloramphenicol, clindamycin, metronidazole,
Clindamycin
PCP alternative
Clindamycin
skin and soft tissue infections
Clindamycin
prophylaxis of endocarditis in pts allergic to pencillin
fluoroquinilones
theophylline, NSAIDs, corticosteroids increase toxicity of this
ok in pregnancy
Isoniazid, Rifampin, Ethampbutol, amoxicillin, tetracycline , tigecycline, aminoglycoside
CI in pregnancy
fluoroquiniline , trimethoprim, cotrimoxazole, Nitrofurantoin,
fluoroquinilones
connective tissue problems , QT prolognation, superinfections
Linezolid
weak irreversible inhibitor of MAO
Naficillin
excreted in bile
Pencillin
AE- hypersnesicity
Ampicillin, Amoxicillin
maculopapular rash
intersittial npehritis
methicillin
pseudomembrane colitis
ampicillin
ticacillin
hematologic toxicity
naficillin
neutropenia
oxacillin
hepatitis
cefazolin
DOC for surgical prophylaxis
2nd gen (cefaclor, cefoxitin, cefotetan, cefamandole)
sinusiits, otitis, LRTI
cofetetan and cefoxitin
propylasis and therapy for abd and pelvic cavitiy infections
ceftriaxone (3)
DOC for pencillin resistant gonorreal
ceftriaxone (3)
DOC for meningitis due to ampliccilin H infleunza
ceftriaxone (3)
tx of lyme disease(CNS or joint)
ceftriaxone (3)
prophylaxis of meninigits in exposed individuals
cefoperazone+ceftazidime (3)
P aeuriginoas
cefepime (4)
parental only
cephalosporin
minor infection to pencilin pts are given?
carbepens
DOC for enterobacter
DOC for extended spectrum B lactamase production G-
aztreonam
g negative rods only
vancomycin
g positive bacteiral only
vancomycin
red man sydnrome
daptomycin
tx of complicated skin/sturcutre infections caused by S aurues
daptomycin
elevated creatineine phosphokinases
bacitracin
topical due to marked nephrotoxicity
fosfomycin
tx for uncomplicated UTIs
tetracycline
severe acne and rosaciea
tetracycline
community acquired pnumonia out pts
tetracycline
syhilis in pts allergic to penicillin
tetracycline
DOC for chlamydia
tetracycline
DOC for mycoplasma
tetracycline
DOC for lyme disease
tetracycline
DOC for cholera
tetracycline
DOC for anthrax propylaixs
tetracycline
DOC for rickettsia
docycline
STDs and prostaticis
minocycline
eradication of meningococcal carrier state
clofazime
red brown discloration of skin
dapsone
erythema nodosum leprosum
pyrazinamide
nongouty polyathralgia
ethambutol
dose dependent visual disturbances
isoniazid
peripheral neuritis
pencillin G
doc for syphilis
pencillin G
DOC for strep infections
pencillin G
DOC in suspetible pnumocooi
pencillins
secondary infection of vaginal candiadisis
cefamandole, cefoperazone, cefotetam
hypoprothrombineia, disulfiram like rxns
vancomycin
resistance- modification of D-ala-Dala
tetracycline
tx of plague, tularemia, brucellosis
aminoglycosides
once daily dosing
aminoglycosides
amikacin, gentamycin, tobramycin, streptomycin, neopmycin, netilimicin
aminoglycosides
otoxic and nephrotoxic
macrolides
erythromycin, clarithromycin, azithromycin, telitrhomycin
telithromycin
fatal hepatoxicity
chloramphenicol
topical treatment of ear and eye infections
moxifloxin, gemifloxacin
community acquired pnumonia
levoflaxcin
prostitis, STDs
Ciporfolxin
travelers diarrhea, meningiits prophylaxis
sulfanamides
inhbit dihydropetroate syntahse
trimethoprim
inhibts didhyrofolate reductase
suflonamides
UC, entertitis IBD
sulfanamides
crystalluria+kernicterus
trimethoprim
antifolate effects
cotrimoxazole
DOC for PCP
cotrimoxazole
DOC for norcaoidsosi and toxoplasmosis
metronidazole
brain abscesses
metronidazole
disufiram like effect
fluroquinlones
tendon rupture/damange in fetus
neitrofurantoin
hemolytic anemia in fetus
aminoglycosides
damange to VIII cranial nerve
metronidazole or vancomycin
tx for c difficiline
metronidazole
DOC for tricamonas
amibicllin
DOC for proteus
docycline
DOC for rickettsia
oseltamivir, zanamivir
neuraminidase inhibitors
zanamivir
airway irritaiton
amantidine, rimatadine
ion channel blockers
ribavarin
prevents viral mRNA capping
ribavarin
pregenacy category X
interferons
flu like, fatigue mental depression- AE
interferon alpha
HCV, HBC, condyloma acumnata, hairy cell, kapisis
interferon B
MS
adefovir
severe exacerbation of hepatitis
ganciclovir
DOC for CMV retitnitis and CMV prophylaxis in immunocomprised
cidofovir
requires activation by host cell kinase, not phosphorylated by viral kinase, CMV retinitis in HIV/AIDS
trifuluridine
DOC for HSV keratoconjunctivitis and recurrent epithelial keratitis
fomivirsen
use for CMV when other therapies for CMV fail
foscarnet
nephtrotoxicity and hypocalcemia
amantidine, rimatadine
inhibit uncoating by blocking M2 proton channel
fomiverin
inhibits CMV protein syntehsi, AE- visual issues
foscarnet
no phpshorylation required, CMV in immunocompr and acyclo resistant, viral DNA pol inhibits, AE- nephro, hypocalcemia, CNS
vidarabine, trifulride
HSV keratitis, keratoconjuncitivity, AE- light sensivity
penciclovir
HSV- cold sores, recurrent gen herpes in immunocomprise, viral kinase , topical tx
ganciclovir
AE- mylosupression DOC for CMV retinitis
acyclovir
AE- renal dysfunction and GI disturbance
amantidine, rimatadine
blocks M2 proton channel, AE- GI, CNS(amnamtidine)
ribavarin
teratogenic, RSV, HepC, prevents viral mRNA capping
Lamivudine, Adefovir, Entecarvi, Telbivudine
phos by cellulary kiasne AE- severe hepatitis after discontiuation
vidarabine
adenine analog
trifuluridine
thymidine analog, DOC for HSV keratoconjuscitivity
famcilcovir
acute herpes zoster infections and reucrrent genital herpes in immunocrompromised
acylovir IV
acute renal failure
acyclovir
compltes with dGTP, chain termination and inhibit viral DNA pol
acyclovir
DOC for HSV encephalitis
telbivudine
HBV
entacavir
lamivuidne resistant HBV and HIV , AE- severe hepatitis
adefovir
Hep B, HIV, AE- severe hepatits
Lamivudine
Hep B and HIV
ribavarin
pregnancy cateogry X , prevents viral mRNA capping, against RSV, HCV,lassa
amanitidne, rimainatide
CI in pregnancy and nuring
zanavir
inhaled neurandimase inhibitor
ursodiol
dissovles gall stones in bile ducts
pancreatic enzymes
tx for chronic pancreatitis, maabsortion syndrome
diphenoxylate and loperamidie
toxic megacolon
droperidon haloperidol , prochlorperazine , metocloprimonade
blcoks D2 recetors
lactulose
tx of heaptic encephalotpahty that prvents hyperammonia
Metaclorpomaide
CI in Parkinsons
Metaclorpomaide
diabetic gastroperises, anti emetic and GERD
pirenzepine and dicylcomine
muscarinic antagonists used for IBS
misoprostol
prevention of gastric ulcers induced by NSAIDs
sucralfate
requires acid pH for plymeraziation
cimetidine
gynecomastia, galtorreha, reduced sperm count
calcrium carbomnate
kidney stoens
aluminum hdyroxide
constipation
MgOH
diarrhea
HIV CI
live vaccines- MMR, varicella, zoster
HIV prolypalctic vaccines
s pneumo, hep A, hep B, infeluza
les severe needle stick
2NRTIs+AZT+lamivudine
more severe needle still
3 drgus 2 NRTIs+PI or NNRTI
recommendation for HIV drug in pregnancy
ritonavir boosted lopinavir+zidovudine/lamivudine
iftants of HV infected moms
zidovudine(6w)
INSTI based regimen
raltegavir, tenofovir, emitricitabine
NNRTI based regimen
efavirenz+tenofovir+emtricitabine
PI based regimen
ritovair boosted atazanivir or darunavir+tenofovir+ emtricitabine
raltegravir
UGT1A1 glucornation
raltegravir
binds to integrase and inhibits first step of intergration, tx experienced and navie
Maraviroc
CCR5 binder, blocks HIV entry, CYP3A4
Enfufirtide
AE- injection, no DI , inhibits viral fusion, tx experienced, simlar to gp41
Pis
end in navir
Nelfinavir
cant be boosted by rtv, CYPs
lopinavir
preferrenzed PI, enzyme inducer(CYP), avoid disufiram or metronidazole
atazinavir
ATV+RTV only daily preferred PI, sturcturally not rel to Pis, CYP3A4, admin separate from H2B or antasis, less side effects than other Pis
Tipranavir
use when reistant to other Pis, CYP inducer, fatal helatptis and intracranial hmeorage
Darunavir
use when reistant to other Pis, CYP inducer
ritonavir
PK enhancer, booskter of other Pis, CYP inhibot
saquinavir
take with high fat meal
indinavirl
absorptions decreased with meanls
PI resistance
mutations in protease gene
PI AE
GI inholerance, parestisea, lipid metabolism, fat redistribution and accumualtion
atazinavir
less side effects than other Pis
efavirenz
preffered NNRTI, once a day, CNS AE+rash, cat D in pregnacy , CYP inducer
etravirine
tx ecp pts, CYP metab, transamination elevation+rash, CI- CYP drugs
Delaviridine
CYP, not as widely sued due to shrot half life- AE- rash, teratogenic
neivirapine
CYP inducer, rapid restance, AE- hepatotxicty, rash, needs 14d titratoin to reduce rash risk
NNRTIs AE
skin rash and CYP rxns
NNRTIs
non compeitibve HIV1 inh of RT, inh RNA and DNA dep DNA poly, DOES NOT REQUIRE PHSOPHORYLATION
Abacavir
AE- hypersensitivty rash, don’t give to sensitive pt , guanisine analog
Emtricitabine
preferre NRTIs, cytidine analog, AE- hyperpigmentation of plams and soles
Lamivudine
no effect on mitrochronial DNA syn, high resistance, cytidine analog
tenofovir
guanosine analog, DI with didanoside(increase conc) and azatanir(decreased cons), take with food
didanosine
AE- pancreatitis, CI- stavudine, adenosine analogue, take fasting
zidovudine
bone marrow supression, thymidine analog, BBB penetrator
stavudine
inh of B and gamma DNA pol, AE- peripheral neuropathy and lactic acidosis
NRTIS AE
due to mitochdonrial inhibit of DNA pol- peripheral neupahty, pancreatitis, liportais, liver toxiciy can be fatal
NRTI MOA
terminated DNA elongation b/c clacks 3 OH, comptitive inhibitor of RT, HIV 1 and 2
NNRTIs naming
have vir in the middle
NRTIS naming
vudine
teribinadine
inhibits squaline epoxide which inhibits ergestrol
amphotercin
binds to ergestrol and forms pores
flucytosine
inhibits thymidylate synthtease which inhibits dTMP
azole
inibits 14 alpha sterol demymehtlase
capsifungin
inhibits syntheiss of B 1-3 D glucans in fungal cell wall
griseofulvin
disrupts mitotic simples and inhibits mitosis
Amph B AE
infuion related+nephrotxic, less with lipid ones
flucytosine AE
bone marrow toxciicty+ 5-FU toxic metabolitte, enters CSF
ketoconazole
gynecomastia
teribinadine AE
no drug interaciotns
Fluconazole
DOC for esophageal, oral, vaginal candiaics
Fluconazole
DOC invasive candiadias infection
Fluconazole
DOC for coccoides
Fluconazole
DOC for matain cocicdes
Fluconazole
propyhylaixs for crytocossus
itraconazole
DOC for aspergillus
voriconazole
DOC for invasive aspergillus
posaconazole
mucor
griseofulvin
dermatophotises
clotrimiazole and micronaole
topical azomes
clotimazole
DOC for PCP
chloruqine sensitive in preg women
chloroqine
chrlorquine res in preg women
mefloquine
malaria propylaxis where chlorquine resistant
mefloquine , doxycycline, primaquine
severe malaira in pregnant women
quinine or artersunate in first tripmester, 2nd and 3rd- artesunate and atemetehr
severe malaria
quininidine+doxyclycline, tetracycline or clindamycin, artesunate+atovaquone-progunail, doxycline, or mefloquine
uncomplicated malaria p falciparum
chroquine reistance, atovquote-proguanil, artemeter-lumenfratine
uncomplicated malaria p falciparum
chloroquineine sensitive, recommended- chloroquine/hydrochlorouine
umcomplicated malaira/p malarie
recommended- chloroquine, hydrochloroquine
Halofantine AE
teratogenic
artemisin
short half life, generates free radicals by binding to iron, use in 2nd or third trimester
artemisin
tx of severe, MDR p malcipaurm
docyclcine/tetraclycine AE
photoensiivty, CI in pregnancy(hepatotxocity)
docycline+quinine
severe falcipaurm malaria
proguianil
folate systehsis inhibitor, mouth ulcers, alopecia
prymethambine-sulfadones,
steven johnson synme, erythema mutliform, epidermal necrosis
sufonamide MOA
dihyropetroate synthase inhibitor
pyrimethamine and proguanil MOA
inhibits dihydrofolate reductase
prymetahime-sulfoxamine
chrooquine res malaria, DO NOT sue in severe malaira
atovaquone MOA
disrupts mitocondrial electrol transport
primaquine
CI in pregnancy
malarone
atovaquone+proguanil
primaquine
DOC for liver forms of P vivax and P ovale
mefloquine
weeky prophylactic dsoing
mefloquine AE
CNS toxcitiei
mefloquine
DOC as prophylaxis in preg women
meflowuine and artesunate
uncomp malaria in SE asia
Quinidine CI
cardiac problems, visual or audtiory problems, mefloquine
quinidine in preg women
if benefits outweigh risks
quindine and quinine AE
hypotension, ECG abnomlaities, black water fever , cinchonism, uterine contractions, hypoglycemia, hyerspensivity
quinine
oral, umcomp maalria
quindine
severe malaria, IV
chloroquine
prevents polymeraization to hemozoin
complciated malaria
coma, anemia, renal failure, pul edema, resp distress, shock, DIC, bleeidng, hemoglobinura, convuslions
p falciparunm
rapid progressive severe illness or death
p vivax and p ovale
hypnozoites in liver
lab dx of malaria
thick or think blood smear
malaria praxoysm
fever, anemia, jaundice, splenomegaly, hepatomegaly
mosquito that incoulates plasmodium
anopheline mosquito
leishmanais
sodium stibogluconate/amph B
tx of toxoplasmosis
pryrimateine+clindamycin OR sufadizin OR folicinic acid
PCP hemolytic stages
pentamide
trypanosomiasis
melarsoprol or suramin
metronidazole
DOC for giardia and trichomonas vaginalis
fasciola hepatica DOC
bithionol
Shistosoma DOC
praziquantel
paragonimus westermani
praziquantel
Echinococus granulosus
albendazole
taenia solium
praziquantel or niclosamide
taenia saginanta
praziquantel or niclosamide
cysticercosis
albendazole or praziquantel
diphyllbothrium
praziquiantel
ascardis lumbroicodies DOC round worm
albendazo,e pyrantel pamoate, mebednazole
entrobius vernmicularis DOC, pin worm
mebendazole or pyrantel pamoate
whip worm, trichirus trichura DOC
mebendazole or albendazole
hook worm, anclycostoma dudoneale, necator americanus DOC
pyrantel pamoate or mebendazole or albendazole
onchocerca volvulus (river blindness)- DOC
ivermectin
cutaeous larva migrans
albendazole or ivermectin
DOC visceral larva migrans
albendazole
trichenra spiralis DOC
albendazole or mebendazole, cortocoistersd for sever infection
lyphatic filiaris DOC
diethycarbamazine
loiasis DOC
diethycarbamazine
strongyloidasis DOC thread worm
ivermectin
niclosamide pK
give with laxative since doenst kill ova, avoid aclohol
praquqantel AE
CI in pregnacy, CI in tx of ocular cysticercosis , first pass emtabolsim
praziquante
DOC of shistosomias, tremadie and cestode
cysticercosis DOC
albendazole
praziquantel MOA
contracture and paralysis of worm
diethycarbamazine
DOC for tx of lymphatic fialrias, loisaiss and trpicl eospinophia
diethycarbamazine MOA
immobilizes microfilirae
piperazine + ivermectin MOA
GABA agonist
Piperzine Use
tx of pinworm and round worm
Piperazine AE
CI in seizure pts
pyrantel pamoate
roundworm, pinworm, hook worm
pyrantel pamoate
depolrizing neuromuscular blocker
ivermectin AE
mazotti rxn(dizziness, fever, somnolence, hypotneion), CI in pregancy, CI in meningitis
thiabendazome
threadworm, cutanous larba migrans, thrichonoss
thiabendazole MOA
affects microtubular aggregation, CNS distrubances, CI in pregnancy , steven johnson and ertyrhema
mebendazole DOC
whip worm, pink worm, hook worm, round worm
Albendazol AE
hepatoxitiy in hyatid tx, CI in pregancy, inf due to dying arasites in CNS, convulsions
nematodes
elongated round worms, complte digestive system, blood and itsue infeciton
tremadote
flat, in liver, intestine, blood, flukes
helminths
flat and segemtned, lack mouth and digestive system, attach to host intestine
diloxdamie furoaet
asymptomatic intestinal amebiais infection
metronidazole+luminal agent
mild-mod intestinal infeciton
metrodianze or tinazole+luminal agent
severe intestinal infeciotn
metronidazole or tinidazole+luminal agent
hepatic abscess+etraintestinal disease
luminal DOC for amebiais
diloxanide fluorate
emetine and dehydrmeme AE
pain at site of infeciton
emetine and dehydrmeme AE
back up for tx of severe intesitnal or hepatic amebiais
paramomycin AE
gi distress and diarrhea
paramyocin
only agaisnt luminal E histolipical
lodoquinol
lumnaim trophozite and cyst forms of E histolyica
metronidazole AE
GI ditress and disulfarm
metrodnizaole MOA
reduced by reacting with reduced ferroxin
metronidaozle
DOC for invasive amebaissi
metronxiaole
giardia, trichomonas vaginalis, anaerobic cocci, anaerobic g- bacilli, H pylori eradicaton
cysts of E hystlocyla
can survive ousode of body