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13 Cards in this Set
- Front
- Back
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HD affects what structures most? the ____ which consists of the ____ and the _____, with the latter being affected most significantly
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certain basal ganglia structures: striatum (putamen + caudate nucleus)--caudate nucleus in particular; nucleus accumbens to a lesser extent
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what is the triad of clinical sxs found in HD (i.e. sxs in these 3 areas)?
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motor sx, cognitive sx, behavioral sx (to be elaborated in following cards)
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name some of the motor sxs seen in HD
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involuntary movements (usu. choreiform); unsteady gait (appear intoxicated); abnormalities in eye movements; difficulty with speech and swallowing
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name some bx changes in HD
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personality change, depression, mood swings
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name some npsych findings in HD when progressed (as with other subcortical dementias): deficits in the domains of ___ and ___, difficulty with the ____ aspect of memory, and ____aphasia
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executive fxs, attention;
retrieval (recognition mem. rel. preserved); anomic |
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on what criterion does the dx of HD traditionally rest?
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emergence of chorea (choreiform movement d/o)
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HD is a (static/progressive) illness that is (lethal/nonlethal) with a usual onset in the __ to __ decades
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progressive (of course, as a neurodegenerative illness), lethal, 3rd to 5th
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what tx helps to delay onset/slow decline in HD? what tx may help with chorea sxs?
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there is none presently; antidopaminergic agents
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mood disorders occur in approx(1/4, 1/2, 3/4) of pts with HD
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1/2
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Huntington Study Group created the HD battery UHDRS, assessing motor, cog, bx and functional sxs. Includes these 3 tests, which are among those that are sensitive to basal ganglia dysfx:
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Stroop, Digit Symbol, Verbal Fluency
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initial sxs in HD usually include subtle ___ and motor ______, and disturbances in ____
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chorea, clumsiness, behavior
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common pyschiatric manifestations of HD include _____ disorders, _____ disorder, and/or impulsive or destructive ____-like behavior
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affective, obs.compulsive, manic
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atrophy of the caudate and putamen in HD can cause the __________ to appear enlarged in MRI or CT scans
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lateral ventricles
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