Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
What is the triad of symptoms that HD presents with?
|
Motor symptoms
Psychiatric symptoms Cognitive deficits |
|
|
What is the one thing you need to assess every time you see a HD patient?
|
Risk for suicide
|
|
|
What is one of the central cognitive deficits seen in HD patients
|
Along with dementia, you see a decrease in processing speed
|
|
|
What is the presentation of Juvenile HD
|
Myoclonus, Seizures, Parkinsonism, Cognitive change. Choreiform movements are typically absent.
|
|
|
What can be used for diagnosis of HD?
|
Family history
Physical exam Genetic testing Neuroimaging (caudate atrophy) |
|
|
What is the treatment program for HD?
|
Currently, there are no disease modifying agents for HD
|
|
|
What is the breakdown of treatments for HD?
|
10% medicine and 90% supportive and behavioral
|
|
|
What is the first primary step/referral for an HD patient?
|
With the Huntington Disease Society of America
|
|
|
Are there any treatments for cognitive symptoms?
What drug should theoretically work? |
No, there are no current treatments for dementia
Namenda should theoretically work since it's an NMDA receptor agonist, but there aren't many studies on it |
|
|
Where is the focus for cognitive symptoms treatment?
|
On non-pharmacological treatment
|
|
|
What is used to treat psychosis or agitation in HD patients?
|
Typical antipsychotics, such as Quetiapine.
(Risperiodone, haloperidol = worse cases) |
|
|
What is the treatment for chorea?
|
Non-pharmacologic treatment mainly, first determine if the patient requires treatment, chorea movements often don't bother the person. Mainly, provide a calm stable environment
|
|
|
What is the one pharmacologic treatment for chorea?
|
Tetrabenazine which is a central monoamine depleting agent: it inhibits presynaptic dopamine release and blocks CNS dopamine receptors. It is useful in milder forms of chorea. It may worsen cognitive problems.
|
|
|
What is another pharmacologic treatment for chorea that treats both psychiatric and motor symptoms?
|
Neuroleptics which can block dopamine transmission at the post-synpatic receptor site and can be used to treat both the psychiatric and motor symptoms in HD, although they can worsen the parkinsonian features.
|
|
|
What atypical antipsychotics can be used to treat chorea?
|
Zyprexa, Abilify and Risperdal are better for mild to moderate chorea.
|
|
|
What typical antipsychotic can be used to treat chorea?
|
Haloperidol is better for moderate to severe chorea
|
|
|
What NDMA receptor antagonist drug could be used to treat chorea?
|
Amantadine
|
|
|
What is one investigational pharmacologic treatment for HD?
|
Creatine, to reduce oxidative stress and slow apoptosis
|
|
|
What is one surgical investigational treatment for HD?
|
DBS: deep brain stimulation of Globus Pallidus interns
|
