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13 Cards in this Set

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  • Back
What virus is the cause of adult T-cell leukemia/lymphoma?
T-cell lymphotropic virus (HTLV-1), which is a retrovirus
Describe the mechanism used by HTLV-1 to cause cancer
The mechanism involves using a "transactivating transcriptional" factor known as the Tax protein, which activates transcription of cell genes encoding Il-2 receptor and IL-2 in T-cells
Describe the integration of the HTLV-1 virus
The site of integration varies from person to person, but the site is the same in each individual, generating a monoclonal line of CD4+ T-cells which become malignant
What are the two cancers caused by Epstein Barr virus and where are these cancers commonly found with EBV infection?
Burkitt's lymphoma (endemic form found in Africa) and nasopharyngeal carcinoma (southern China, Japan)
What are the cell types affected in the cancers caused by EBV?
In Burkitt's, it infects B cells and causes cell proliferation; it affects epithelial cells in nasopharyngeal carcinoma
What are the oncogenes of Burkitt's lymphoma and what chromosomal translocation occurs?
c-myc and the latency membrane protein, which is involved in the induction of bcl-2 gene product; the translocation is t(8;14)
What virus causes Kaposi's sarcoma in AIDS patients?
HHV-8
What is primary effusion lymphoma and what is it's viral cause?
This is a lymphoproliferative disease caused by HHV-8
What is the AIDS associated malignancy associated with HHV-8 and EBV?
Body cavity based lymphoma
What virus infections are associated with primary hepatocellular carcinoma?
Hep B and Hep C because of the chronic carrier state that occurs
What viruses are responsible for the majority of cervical intraepithelia neoplasia and carcinoma?
HPV-16 and HPV-18
What viruses cause condyloma accuminata?
HPV-6 and HPV-11
What is the oncogenic mechanism of HPV-16?
The E6 and E7 proteins associate with and inactivate tumor suppressor genes p53 and RB