Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
What virus is the cause of adult T-cell leukemia/lymphoma?
|
T-cell lymphotropic virus (HTLV-1), which is a retrovirus
|
|
Describe the mechanism used by HTLV-1 to cause cancer
|
The mechanism involves using a "transactivating transcriptional" factor known as the Tax protein, which activates transcription of cell genes encoding Il-2 receptor and IL-2 in T-cells
|
|
Describe the integration of the HTLV-1 virus
|
The site of integration varies from person to person, but the site is the same in each individual, generating a monoclonal line of CD4+ T-cells which become malignant
|
|
What are the two cancers caused by Epstein Barr virus and where are these cancers commonly found with EBV infection?
|
Burkitt's lymphoma (endemic form found in Africa) and nasopharyngeal carcinoma (southern China, Japan)
|
|
What are the cell types affected in the cancers caused by EBV?
|
In Burkitt's, it infects B cells and causes cell proliferation; it affects epithelial cells in nasopharyngeal carcinoma
|
|
What are the oncogenes of Burkitt's lymphoma and what chromosomal translocation occurs?
|
c-myc and the latency membrane protein, which is involved in the induction of bcl-2 gene product; the translocation is t(8;14)
|
|
What virus causes Kaposi's sarcoma in AIDS patients?
|
HHV-8
|
|
What is primary effusion lymphoma and what is it's viral cause?
|
This is a lymphoproliferative disease caused by HHV-8
|
|
What is the AIDS associated malignancy associated with HHV-8 and EBV?
|
Body cavity based lymphoma
|
|
What virus infections are associated with primary hepatocellular carcinoma?
|
Hep B and Hep C because of the chronic carrier state that occurs
|
|
What viruses are responsible for the majority of cervical intraepithelia neoplasia and carcinoma?
|
HPV-16 and HPV-18
|
|
What viruses cause condyloma accuminata?
|
HPV-6 and HPV-11
|
|
What is the oncogenic mechanism of HPV-16?
|
The E6 and E7 proteins associate with and inactivate tumor suppressor genes p53 and RB
|