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15 Cards in this Set

  • Front
  • Back
Polypeptide NTs (neuropeptides)
-promotes satiety following meals
Substance P
Polypeptide NTs (neuropeptides)
-is a pain NT
Endorphins, enkephalins and dynorphin
Polypeptide NTs (neuropeptides)
-are endogenous opioid NTs
-Promote analgesia and mediate many placebo effects
-Effects are blocked by naloxone, an opiate antagonist
Neuropeptide Y
Polypeptide NTs (neuropeptides)
-is most common neuropeptide
Inhibits glutamate in hippocampus
-Powerful stimulator of appetite
Polypeptide NTs (neuropeptides)
- similar to THC in marijuana
Are the only lipid NTs
Not stored in vesicles; are produced from lipids of the plasma membrane
Are retrograde NTs: they act on neuron that releases them
And thereby may be involved in learning
Like THC, they stimulate appetite
NO and CO
Gaseous NTs
-Act through cGMP second messenger system
-NO causes smooth muscle relaxation
Glutamic acid and aspartic acid
Amino Acids NTs
-are major CNS excitatory NTs
Amino Acids NTs
-is an inhibitory NT
-Opens Cl- channels which hyperpolarize
-Strychnine blocks glycine receptors
Causes spastic paralysis
Amino Acids NTs
-(gamma-aminobutyric acid) is most common NT in brain
-Inhibitory, opens Cl- channels
-These degenerate in Huntington’s disease
-Epinephrine, Norepinephrine and dopamine are derived from tyrosine
Monoamine NTs
-serotonin, epinephrine, norepinephrine and dopamine
Nigrostriatal dopamine system
-originates in the substantia nigra and is involved in motor control
-Degeneration of this system causes Parkinson's disease
Mesolimbic dopamine system
-is involved in behavior and emotional reward
-Most addictions activate this system
-Overactivity contributes to schizophrenia
Which is treated by anti-dopamine drugs
Norepinephrine (NE)
-Used in PNS and CNS
In PNS is a sympathetic NT
-In CNS affects general level of arousal
-Amphetamines stimulate NE pathways
Acetylcholine (ACh)
Most widely used NT
Used in brain and ANS; used at all neuromuscular junctions
Has nicotinic and muscarinic receptor subtypes