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31 Cards in this Set
- Front
- Back
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What are the 3 factors that determines the concentration of a hormone in the plasma
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1. Rate and mode of secretion
2. Rate of removal (e.g. metabolism/excretion) 3. Degree of binding (e.g. to plasma protein) |
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Rhythms with of about a day is (Circadian / Ultradian)
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circadian
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patterns which are usually set by neuronal circuits composed in or around an area of the hypothalamus known as the suprachiasmatic nucleus which generate an intrinsic rhythm of firing that is influenced by a variety of environmental clues.
(Circadian / Ultradian) |
Circadian
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Corticol secretion follows the (Circadian / Ultradian) pattern
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Circadian
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Growth hormone secretion follows the (Circadian / Ultradian) pattern
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Circadian
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An hour or less is (Circadian / Ultradian)
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Ultradian
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hormones which are secreted in response to a specific stimulus is termed...
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episodic
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Insulin is an example of what secretion pattern?
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Episodic
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LH and FSH is (Circadian / Ultradian)
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Ultradian
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Steriod hormones are synthesised from....
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cholesterol
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cyclopentanoperhydrophenanthrene are non-polar and therefore l_________
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lipophilic
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Steroid hormones are secreted as soon as they are produced this is termed ......
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Consitutive secretion
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Following a stimulus, it requires 3-5 min before steroid hormones detectable in plasma and 10 – 15 minutes to max secretion. True or False
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True
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Protein synthesis and modification occurs in ......
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The golgi apparatus
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Peptides and proteins are released from cells by e________ by Ca2+
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exocytosis
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Many peptide & protein hormones are synthesised in an i_____ form
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inert
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Where are peptides and proteins cleaved to transform it from preprohormone to prohormone?
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The Golgi
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Peptides and protein hormones have relatively (short/long) lives
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short lives
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The half life of (T3/T4) is 0.5 – 0.75 days
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T3
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The half life of (T3/T4) is 6 - 7 days
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T4
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(Epinephrine/Steroid/Protein) has a half life of 5 -10 minutes
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Epinephrine
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(Epinephrine/Steroid/Protein) has a half life of 4 -120 minutes
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Steroid
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(Epinephrine/Steroid/Protein) has a half life of 15 -170 minutes
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Proteins
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Plasma Albumin binds to which type of hormone?
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thyroid and steroid hormone
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Transport globulin binds to which type of hormone?
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hormone-binding proteins and steroid binding proteins
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Write out the general Michaelis-Menten kinetics equation
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H + P HP
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(Bound/Free) hormone is usually the fraction that is cleared by the liver and kidney by metabolism and excretion
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Free
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What does a low level of trophic hormone and a low level of target gland hormone level suggest?
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Trophic hormone deficiency
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What does a low level of trophic hormone and a high level of target gland hormone level suggest?
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Autonomous secretion by target gland
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What does a high level of trophic hormone and a high level of target gland hormone level suggest?
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Automonous secretion of trophic hormone or resistance to target gland hormone
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What does a high level of trophic hormone and a low level of target gland hormone level suggest?
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Primary failure of target endocrine organ
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