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39 Cards in this Set
- Front
- Back
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Hormones dived into?
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Water soluble
Lipid Soluble |
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Water solubles have receptor where?
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Membrane Receptor
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WHere is the receptor in lipid soluble hormones?
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Inside the cell
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What hormones require phosphorylation?
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Water Soluble
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How is gene expression controlled in Water Soluble?
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cAMP response element binding (CREB) protein
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What proteins are used in Water Soluble Hormones?
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Leucine Zipper
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What protein is used for Lipid Soluble Hormones?
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Zinc Finger Protein
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What are the water soluble hormones?
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Insulin
Glucagon Catecholamines (NE, EPi) |
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What are examples of lipid soluble?
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Steroids
Calcitriol ---> Vit D. Thyroxines (thinks is steroid) Retinoic Acid ----> Vit A. |
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What do you think of with watersoluble hormones?
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Male
Receptor Outside (penis) Zipper (Leucine Zipper) |
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WHat do you think of with Lipid Soluble hormones?
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Female
Receptor Inside Zinc Finger Protein |
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What receptors use Glucagon and Epinephrine?
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cAMP pathway
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What are all the messenger involved in cAMP?
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Gs Adenylate Cyclase ----> Protein Kinase
Gi alpha2 beta2 2MAD |
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What are pathway is used in Vasopressin and Epinephrine (alpha 1)?
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PIP2
PIMP |
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Gq involves?
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HAMMV (hummer)
Gq magazine Think C or K Phospholipase C Protein kinase C DAG, IP3, Ca+ |
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What pathway does Atrial Natriuretic Factor (ANF) and Nitric Oxide (NO) use?
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cGMP
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What pathway does Insulin use?
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INsulin, growth factors
via Tyrosine Kinase |
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What do you see in the PIMP system? (PIP2)
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Gq magazine
Cicis.... C C C Phospholipase C Protein Kinase C Ca+ |
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Who activates the Ca+ release in the Endoplasmic Reticulum E.R.?
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IP3 activates Ca+ release
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What does Ca+ activates what in the PIP2 system?
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Protein Kinase C
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What membrane enzyme is used in the ANF or NO?
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Guanylate Cyclase
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If you want to...
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Use Guanylate Cyclase
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Guanylate cyclase activates what?
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cGMP
G is nice to get some.... |
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cGMP activates what?
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Protein Kinase G
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What does Protein Kinase G do?
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Relaxes Smooth Muscle
Relax and ENjoy the RIDE! |
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Where is nitrous oxide found?
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Heme membrane
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HOw does insulin activate hormone receptors?
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Via Tyrosine Kinase
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WHat do you find in the membrane for Insulin?
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Two beta subunits
cross membrane 2 membrane helix span unlike ANF that has 1 membrane helix span |
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What is unique about the cAMP and PIP2 system?
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THey both have a 7 membrane helix span receptor
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What enzyme of the hormone receptor has only 1 membrane span?
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ANF
guanylate cyclase |
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What hormone receptor has 2 membrane helix span?
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INsulin
Tyrosine Kinase |
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Where does Nitrous Oxide (NO) come from? a.a.?
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Arginine
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What are some drugs that increase NO?
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nitroprusside
Nitroglycerine Isosorbide dinitrate Viagra (Sildenafil) Agina |
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Where is glut 4 found?
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Adipose
Muscle Not Liver Glut-1 |
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What happens if there is a mutation that increases G protein?
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Oncogenic
activation of ras (p21 monomeric) gsp (G2 alpha) |
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What is involved in the p21ras oncogene?
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Colon
Lung Breast Bladder ALL TUMORS!!! liked to Tyrosine Kinase G protein!!! |
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WHat is the mechanism for glucocorticods to cause DM?
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They increase PEPCK activity via response elements causing increase gluconeogenesis
increase in glucose---> DM via Zinc Finger Proteins |
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Which enzyme does Insulin activate in glucose related metabolism?
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Glycogen Synthase
glucose is stored glycogen is made you are in a well-fed state just ate |
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Which enzyme is activated when glucagon is present?
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Glycogen Phosphorylase is activated
degrages glycogen ---> glucose increase the release of glucose you are starving |
