Hormone

Front 1

ER
secr by
end organ horm effects
stimulated by
inhibited by

Back 1

Secr by: ovary Granulosa cells
End organ effects:incr br size, incr rec for LH and PR, decr threshold for uterine contraction, PROLIF PHASE OF MENSTRUAL CYCLE, develops female reproductive organs, secondary sex charac
stim by: FSH 5 alpha reductase
inhib by: ER

Front 2

PR
secr by
end organ horm effects
stimulated by
inhibited by

Back 2

Secr by: granulosa cells
effects: br development, secretory lutein phase,
stim by LH

Front 3

PTH
stimulated by
inhibited by

Back 3

Stim by: decr in serum Ca, mild decr in Mg++
inhibted by large decr in Mg++

Front 4

Danazol

Back 4

mild androgen for treatment of endometriosis

Front 5

Contraceptives

Back 5

ER - suppresses ovulation, doesn't surge and lead to LH surge.
Progestin - doesn't allow endometrium to thicken, prevents implantation.

Front 6

Mifepristone

Back 6

RU-486
steroid
fetal aborption
PR antagonist thusly interferes with HCG from placenta.
Dont use after 6 wks

Front 7

SE of oral contraception
3

Back 7

1. Thromboembolus - esp in those who smoke
2. Hepatomas, hemangiomsas
3. Progestin dominant preparations can raise LDL/HDL ratio.

Front 8

Clomiphene

Back 8

Partial ER agonist
Interferes with ER neg fdbk
stimulates ovulation

Front 9

Incr urinary cAMP

Back 9

High serum PTH

Front 10

Vit D pathway

Back 10

Sunlight produces D3, ingestion from plants gives D2
converted to 25-OH Vit D in liver
1,25-OH Vit D in kids

Front 11

Really high alkaline phosphatase with nl phophate levels

Back 11

Paget dz of bone

Front 12

Decr Ca
incr Phosphate
Nl alk phos

Back 12

Renal insufficiency

Front 13

Incr SHBG
Decr SHBG

Back 13

Incr Sexhormone binding globulin leads to decr levels of circ testosterone -> gynecomastia
Decr SHBG raises free testosterone leading to hirsuitism

Front 14

Addison's dz

Back 14

primary deficiency of cortisol and aldosterone - adrenal atrophy- skin pigmentation
Secondary insufficiency is due to ACTH def and has no pigmentation

Front 15

Secondary Hyperaldosteronism

Back 15

High plasma renin
Due to CHF, renal art stenosis, CRF, cirrhosis, nephrotic syndrome

Front 16

Pheochromocytoma
3 associations

Back 16

NF
MEN IIa,b

Front 17

Glucagonoma

Back 17

Secondary DM
skin: necrolytic migratory erythema

Front 18

VIPoma

Back 18

watery diarrhea, hypokalemia, achlorydia
aka pancreatic cholera
ass with MENI

Front 19

2 causes of HypoPTH

Back 19

surgical excision of thyroid
DiGeorge
trousseaeu sign - BP cuff ->carpal spasm
chvosteks sign - facial tap spasm
Tetany

Front 20

Metabolic effects of thyroid

Back 20

incr:
1.lipolysis (synergy with catechols)
2. stimulates HSL
3. beta receptor upreg
4. Incr Na/K atpase activity (heat intolerance)
5. Incr LDL rec population
Decr:
1. balance btw TG synth and lipolysis favors synthesis.
2. Decr LDL rec population

Front 21

Euthyroid sick syndrome

Back 21

low T3 - bc of decr 5' Nl TSH and T4 monodeiodinaes activity. after systemic illnessl ike pneumonia or sepsis.
Converstion of T4 is impaired, incr rT3 (bc 5'mdi breaks down rT3)
It is protective to decr catabolism

Front 22

Hypercalcemia manifestations

Back 22

Hyperstabilize excitable tissue membranes and reduce nl responsiveness -> weakness, fatigue, constipation

Front 23

Somatostatin actions

Back 23

rls by hypothalamus:
to inhibit TSH and GHRH
rls by pancr:
inhibit insulin, glucagon, gastrin rls
rls by GI mucosa:
in response to H+ to inhibit rls of all GI hormones and gastric H+