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23 Cards in this Set

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ER
secr by
end organ horm effects
stimulated by
inhibited by
Secr by: ovary Granulosa cells
End organ effects:incr br size, incr rec for LH and PR, decr threshold for uterine contraction, PROLIF PHASE OF MENSTRUAL CYCLE, develops female reproductive organs, secondary sex charac
stim by: FSH 5 alpha reductase
inhib by: ER
PR
secr by
end organ horm effects
stimulated by
inhibited by
Secr by: granulosa cells
effects: br development, secretory lutein phase,
stim by LH
PTH
stimulated by
inhibited by
Stim by: decr in serum Ca, mild decr in Mg++
inhibted by large decr in Mg++
Danazol
mild androgen for treatment of endometriosis
Contraceptives
ER - suppresses ovulation, doesn't surge and lead to LH surge.
Progestin - doesn't allow endometrium to thicken, prevents implantation.
Mifepristone
RU-486
steroid
fetal aborption
PR antagonist thusly interferes with HCG from placenta.
Dont use after 6 wks
SE of oral contraception
3
1. Thromboembolus - esp in those who smoke
2. Hepatomas, hemangiomsas
3. Progestin dominant preparations can raise LDL/HDL ratio.
Clomiphene
Partial ER agonist
Interferes with ER neg fdbk
stimulates ovulation
Incr urinary cAMP
High serum PTH
Vit D pathway
Sunlight produces D3, ingestion from plants gives D2
converted to 25-OH Vit D in liver
1,25-OH Vit D in kids
Really high alkaline phosphatase with nl phophate levels
Paget dz of bone
Decr Ca
incr Phosphate
Nl alk phos
Renal insufficiency
Incr SHBG
Decr SHBG
Incr Sexhormone binding globulin leads to decr levels of circ testosterone -> gynecomastia
Decr SHBG raises free testosterone leading to hirsuitism
Addison's dz
primary deficiency of cortisol and aldosterone - adrenal atrophy- skin pigmentation
Secondary insufficiency is due to ACTH def and has no pigmentation
Secondary Hyperaldosteronism
High plasma renin
Due to CHF, renal art stenosis, CRF, cirrhosis, nephrotic syndrome
Pheochromocytoma
3 associations
NF
MEN IIa,b
Glucagonoma
Secondary DM
skin: necrolytic migratory erythema
VIPoma
watery diarrhea, hypokalemia, achlorydia
aka pancreatic cholera
ass with MENI
2 causes of HypoPTH
surgical excision of thyroid
DiGeorge
trousseaeu sign - BP cuff ->carpal spasm
chvosteks sign - facial tap spasm
Tetany
Metabolic effects of thyroid
incr:
1.lipolysis (synergy with catechols)
2. stimulates HSL
3. beta receptor upreg
4. Incr Na/K atpase activity (heat intolerance)
5. Incr LDL rec population
Decr:
1. balance btw TG synth and lipolysis favors synthesis.
2. Decr LDL rec population
Euthyroid sick syndrome
low T3 - bc of decr 5' Nl TSH and T4 monodeiodinaes activity. after systemic illnessl ike pneumonia or sepsis.
Converstion of T4 is impaired, incr rT3 (bc 5'mdi breaks down rT3)
It is protective to decr catabolism
Hypercalcemia manifestations
Hyperstabilize excitable tissue membranes and reduce nl responsiveness -> weakness, fatigue, constipation
Somatostatin actions
rls by hypothalamus:
to inhibit TSH and GHRH
rls by pancr:
inhibit insulin, glucagon, gastrin rls
rls by GI mucosa:
in response to H+ to inhibit rls of all GI hormones and gastric H+