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43 Cards in this Set

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MOA of PIs?
bind to substrate site of protease and prevent cleavage of gagpol, resulting in immature, inactive virus particles that can't be released from the host cell
Class ADRs of PIs?
hyperglycemia
fat maldistribution
hyperlipidemia
increased bleeding in hemophiliac pts
Which PI is used to boost efficacy of other drugs?
ritonavir
Which PI is a CYP2D6 inhibtor?
ritonavir
Which PI can cause heart block and hyperbilirubinemia?
amprenavir
With which PI should high-fat meals be avoided?
amprenavir
Which PIs must ONLY be administered WITH ritonavir?
daruvanir
saquinavir
tipranavir
Which PI causes nephrolithiasis and how can it be avoided?
indinavir

take each dose with 48oz. water
MOA of NRTIs?
Competitive inhibitors of reverse transcriptase; terminates DNA synthesis
What do the NRTIs end in?
-sine
-bine
-dine PLUS
abacavir and tenofovir
Class ADR of NRTI?
Lactic acidosis with hepatic steatosis
Which NRTI is metabolized by alcohol dehydrogenase?
abacavir
Which NRTIs have weight-based dosing?
didanosine
stavudine
Which NRTIs can cause peripheral neuropathies?
didanosine
stavudine
Which NRTIs are analogs and should not be used together?
lamivudine
emtricitabine
Which NRTI is also used for Hep B?
lamivudine
What NRTI can cause lipodystrophy, hyperlipidemia, and pancreatitis?
stavudine
Which NRTI is a nucleotide analog?
tenofovir
Which NRTI should not be used if CrCl <60?
tenofovir
MOA of NNRTIs?
binds reverse transcriptase and causes conformation change so that DNA synthesis cannot occur; noncompetitive inhibitor
What are the three NNRTIs?
delavirdine
efaverinz
nevirapine
Class ADRs of NNRTIs?
rash, increased transaminases
Which NNRTI is a CYP3A4 inhibitor/inducer?
efaverinz
Which NNRTI inhibits CYP3 enzymes?
delavirdine
With which NNRTI should PPIs and H2RAs be avoided, and antacids seperated?
delavirdine
With which NNRTI should high-fat meals be avoided?
efavirenz
Which NNRTI can cause a false positive cannabinoid test?
efavirenz
Which NNRTI should NOT be used during pregnancy?
efavirenz
MOA of fusion inhibitors?
prevents conformational change in gp120 such that HIV1 membrane cannot fuse to CD4 cell membrane
Name the 1 fusion inhibitor.
enfuvirtide
ADRs of fusion inhibitor?
injection site reaction
bacterial pneumonia
hypersensitiviry reactions
GI
fatigue
Where can the fusion inhibitor (enfuvirtide) be injected?
upper arm
anterior thigh
abdomen
What is the boxed warning of ritonavir?
effect on hepatic metabolism of other drugs
What is the boxed warning of amprenavir?
contains propylene glycol
What is the boxed warning of tipranavir?
fatal and nonfatal intracranial hemmorhage
What is the boxed warning of abacavir?
hypersensitivity reactions
What is the boxed warning of didanosine?
pancreatitis
lactic acidosis
What is the boxed warning of stavudine?
pancreatitis
lactic acidosis
What is the boxed warning of zalcitabine (now off the market)?
peripheral neurpathy
pancreatitis
hepatic failure
death in Hep B pts
What is the boxed warning of zidovudine?
hematological toxicities
myopathy
What is the boxed warning of nevirapine?
hepatotoxicity
skin & hypersensitivity reactions
Which HIV drugs contain sulfa moeties?
amprenavir
darunavir
fosamprenavir
tipranavir
Which HIV drugs cause hypersensitivity reactions?
enfuvirtide
nevirapine
abacavir