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43 Cards in this Set
- Front
- Back
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MOA of PIs?
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bind to substrate site of protease and prevent cleavage of gagpol, resulting in immature, inactive virus particles that can't be released from the host cell
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Class ADRs of PIs?
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hyperglycemia
fat maldistribution hyperlipidemia increased bleeding in hemophiliac pts |
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Which PI is used to boost efficacy of other drugs?
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ritonavir
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Which PI is a CYP2D6 inhibtor?
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ritonavir
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Which PI can cause heart block and hyperbilirubinemia?
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amprenavir
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With which PI should high-fat meals be avoided?
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amprenavir
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Which PIs must ONLY be administered WITH ritonavir?
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daruvanir
saquinavir tipranavir |
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Which PI causes nephrolithiasis and how can it be avoided?
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indinavir
take each dose with 48oz. water |
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MOA of NRTIs?
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Competitive inhibitors of reverse transcriptase; terminates DNA synthesis
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What do the NRTIs end in?
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-sine
-bine -dine PLUS abacavir and tenofovir |
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Class ADR of NRTI?
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Lactic acidosis with hepatic steatosis
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Which NRTI is metabolized by alcohol dehydrogenase?
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abacavir
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Which NRTIs have weight-based dosing?
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didanosine
stavudine |
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Which NRTIs can cause peripheral neuropathies?
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didanosine
stavudine |
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Which NRTIs are analogs and should not be used together?
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lamivudine
emtricitabine |
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Which NRTI is also used for Hep B?
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lamivudine
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What NRTI can cause lipodystrophy, hyperlipidemia, and pancreatitis?
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stavudine
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Which NRTI is a nucleotide analog?
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tenofovir
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Which NRTI should not be used if CrCl <60?
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tenofovir
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MOA of NNRTIs?
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binds reverse transcriptase and causes conformation change so that DNA synthesis cannot occur; noncompetitive inhibitor
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What are the three NNRTIs?
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delavirdine
efaverinz nevirapine |
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Class ADRs of NNRTIs?
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rash, increased transaminases
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Which NNRTI is a CYP3A4 inhibitor/inducer?
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efaverinz
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Which NNRTI inhibits CYP3 enzymes?
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delavirdine
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With which NNRTI should PPIs and H2RAs be avoided, and antacids seperated?
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delavirdine
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With which NNRTI should high-fat meals be avoided?
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efavirenz
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Which NNRTI can cause a false positive cannabinoid test?
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efavirenz
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Which NNRTI should NOT be used during pregnancy?
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efavirenz
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MOA of fusion inhibitors?
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prevents conformational change in gp120 such that HIV1 membrane cannot fuse to CD4 cell membrane
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Name the 1 fusion inhibitor.
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enfuvirtide
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ADRs of fusion inhibitor?
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injection site reaction
bacterial pneumonia hypersensitiviry reactions GI fatigue |
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Where can the fusion inhibitor (enfuvirtide) be injected?
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upper arm
anterior thigh abdomen |
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What is the boxed warning of ritonavir?
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effect on hepatic metabolism of other drugs
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What is the boxed warning of amprenavir?
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contains propylene glycol
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What is the boxed warning of tipranavir?
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fatal and nonfatal intracranial hemmorhage
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What is the boxed warning of abacavir?
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hypersensitivity reactions
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What is the boxed warning of didanosine?
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pancreatitis
lactic acidosis |
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What is the boxed warning of stavudine?
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pancreatitis
lactic acidosis |
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What is the boxed warning of zalcitabine (now off the market)?
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peripheral neurpathy
pancreatitis hepatic failure death in Hep B pts |
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What is the boxed warning of zidovudine?
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hematological toxicities
myopathy |
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What is the boxed warning of nevirapine?
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hepatotoxicity
skin & hypersensitivity reactions |
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Which HIV drugs contain sulfa moeties?
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amprenavir
darunavir fosamprenavir tipranavir |
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Which HIV drugs cause hypersensitivity reactions?
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enfuvirtide
nevirapine abacavir |
