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29 Cards in this Set

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  • Back
What is saquinavir?
Protease inhibitor HIV

Navir tease a protease!!
What is ritonavir?
Protease inhibitor HIV
What is indinavir?
Protease inhibitor HIV
What is nelfinavir?
Protease inhibitor HIV
What is amprenavir.
Protease inhibitor HIV
What is MOA of saquinavir?
Inhibit assembly of new virus by blocking protease enzyme.
What is the toxicity of protease inhibitors HIV?
nauses, diarrhea, hyperglycemia, lipid abnormalities.
What is a main side effect of indinavir HIV therapy?
thrombocytopenia.
What is the MC side effect of HIV protease inhibitor therapy?
nausea, vomiting, diarrhea.
What are the two types of reverse transcriptase inhibitors of HIV?
1) Nucleoside
2) Non-nucleoside.
What is zidovudine?
AZT

Nucleoside Reverse Transcriptase inhibitor.
What is didanosine?
Nucleoside Reverse Transcriptase inhibitor.
What is zalcitabine?
Nucleoside Reverse Transcriptase inhibitor.
What is stavudine?
Nucleoside Reverse Transcriptase inhibitor.
What is lamivudine?
Nucleoside Reverse Transcriptase inhibitor.
What is nevirapine?
Non-nucleoside reverse transcriptase inhibitor

"vir" drugs
What is delavirdine?
Non-nucleoside reverse transcriptase inhibitor

"vir" drugs
What is efavirenz?
Non-nucleoside reverse transcriptase inhibitor

"vir" drugs
What is a mjor toxicity of reverse transcriptase inhibitors of HIV therapy?
bone marrow suppression and peripheral neuropathy.
Which class of drugs can cause lactic acidosis?
Nucleoside reverse transcriptase inhibitors!! Can inhitib human mitochondrial enzymes so cells switch to anaerobic metabolism.
What is the main side effect of non-nucleoside reverse transcriptase inhibitors?
Rash
What is the main side effect of zidovudine (AZT)?
Nucleoside reverse transcriptase inhibitor.

Megaloblastic anemia!!!
What is the mechanism of action of nevirapine?
Bind to non-enzymatic portion of reverse transcriptase inhibitor leading to conformational change in the enzyme and making it inactive: allosteric inhibition!!
What is the main side effect of non-nucleoside reverse transcriptase inhibitors?
Rash
What is the main side effect of zidovudine (AZT)?
Nucleoside reverse transcriptase inhibitor.

Megaloblastic anemia!!!
What is the mechanism of action of nevirapine?
Bind to non-enzymatic portion of reverse transcriptase inhibitor leading to conformational change in the enzyme and making it inactive: allosteric inhibition!!
What is MOA of delavirdine?
Bind to non-enzymatic portion of reverse transcriptase inhibitor leading to conformational change in the enzyme and making it inactive: allosteric inhibition!!
What does HAART antiretroviral therapy include?
Protease inhibitor and reverse transcriptase inhibitor. Started when patients have CD4 count less than 500 or when they have high viral load.
What drug can be given in pregnancy to reduce risk of fatal HIV transmission?
AZT (zidovudine).