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4 Cards in this Set
- Front
- Back
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Abacabir (ABC)
Brand? Dosing? Food? |
Brand: Ziagen, Trizivir, Epzicom
Dosing: 300 mg BID or 600 mg daily Food: w/o regards to meals; alcohol increases levels by 41% |
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Abacavir (ABC)
Class: Metabolism/elimination: Adverse events: |
Class: NRTI
Elimination: EtOH dehydrogenase, glucuronyl transferase; renal elimination of metabolites Adverse Events: Hypersensitivity reaction (possibly fatal), fever, rash, nausea, vomiting, malaise/fatigue, loss of appetite |
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Tipranavir (TPV)
Brand: Dosing: Food: |
Brand: Aptivus (250 mg caps)
Dose: 500 mg BID w/ritonavir 200 mg BID (unboosted not recommended) Food: take both TPV and RTV with food - increases bioavailability with a high fat meal |
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Tipranavir (TPV)
Class: Metabolism/elimination: Adverse events: |
Class: PI
Metabolism/elimination: 3A4 inducer/substrate; net effect when combined with RTV: CYP3A4 inhibitor & 2D6 inhibitor Adverse events: Hepatotoxicity, skin rash (sulfonamide moiety), hyperlipidemia (esp. TG), hyperglycemia, fat maldustribution, possible increased risk of bleeding in pts with hemophilia |
