Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
|
Nucleoside Reverse Transcriptase Inhibitors (NRTIs) side effects
|
"Whole Milk": Lactic Acidosis & hepatic steatosis
|
|
|
Nucleoside Reverse Transcriptase Inhibitors (NRTIs) drugs
|
Dizzy Standing Lamb EMT Did Aba
Lamb, w/ Siren above head (EMT), Did (singing), Aba, Dizzy, Standing 3,4,5,6, 1,2 |
|
|
zidovudine (AZT,Retrovir)
analogue of |
"AZT - A-Z", "Prevents everything, goes everywhere"
bone, kidney, CNS NRTI, Thymidine analogue |
|
|
stavudine (d4T, Zerit)
analogue of |
"Acid Did not Stand his Pancreatitis"
peripheral neuropathy, m pain, m weakness, pancreatitis Thymine analogue |
|
|
lamivudine (3TC, Epivir)
analogue of |
"lami is lame: resistance develops rapidly - so only combo"
LamB = hep B treatment NRTI C analogue |
|
|
emtricitabine (FTC, Emtriva)
analogue of |
"Em cee trying to be lame" Fluorinated analog of lamivudine (a C analogue)
NRTI C analogue |
|
|
didanosine (ddI, Videx)
analogue of |
"Acid Did not Stand his Pancreatitis"
Acid-labile (IV or entero coating), peripheral neuropathy, m pain, m weakness, pancreatitis NRTI A analogue |
|
|
abacavir (ABC, Ziagen)
analogue of |
"Hypersensitive to ABBAs music"
NRTI G analogue |
|
|
Combivir
|
(zidovudine + lamivudine)
|
|
|
Trizivir
|
(zidovudine + lamivudine + abacavir)
|
|
|
Epzicom
|
(abacavir + lamivudine); "ABBA
s new EP is LAMe" |
|
|
Truvada
|
(tenofovir + emtricitabine)
"ten true EMTs" |
|
|
tenofovir (TDF, Viread)
|
"Fo for Fanconi, that wuss": Renal impairment -> pee everything (glucose, AA, lots of pee), Asthenia, Dizziness"
NucleoTide Reverse Transcriptase Inhibitor |
|
|
nevirapine (NVP, Viramune)
|
NNRTI
"Nevi = mole, Nevi = Levi (tight on liver) but look hot (arouse guys)": RASH = sign of liver failure - Stevens-Johnson Syndrome (maculopapular rash, flu-like symptoms) Squeeze liver = hepatitis, enzyme inducer |
|
|
efavirenz (EFV, Sustiva)
|
NNRTIs
"Efa (or Eva) in your dreams, arouses you. Don't get her pregnant": Dizzy, insomnia, can't concentrate (thinking about Eva too much), vivid Dreams/Nightmares Arouse = CYP3A4 inducer Don't preg = Teratogenic |
|
|
Protease Inhibitors (PIs) side effects (common)
|
"Puddha (like Buddha)""Fat, Lazy, Diabetic": fat - lipodystrophy & hyperlipidemia
N/V/D DM-like (c/o fat Buddha) = peripheral neuropathy & hyerglycemia Buddha in trance/meditation = Inhib CYP3A |
|
|
Protease Inhibitors (PIs) drugs; combinations
|
"Saq riton Kaletra who Lops it off in an Atack Darun Fosam"
Ritonavir with all except optional w/ Atazanavir or fosamprenavir |
|
|
saquinavir (SQV, Invirase, Fortovase)
|
poorly absorbed, weak
"Didn't go in, impotent, 1st pass" |
|
|
ritonavir (RTV, Norvir)
|
"Right on - good oral"
Pharmokinetic enhancer: inhib CYP3A4 "in a TON of PIs" |
|
|
Kaletra
|
lopinavir + ritonavir (LPV/RTV)
|
|
|
atazanavir (ATV, Reyatax)
|
"Need acid for your Atack on Glucoron"
Riton optional |
|
|
darunavir (Prezista)
|
"Darun the big gun, Eats til he's Red in the face and says 'Right on'"
|
|
|
fosamprenavir (FPV, Lexiva)
|
"Sam & Steven's Excellent Adventure of Skin lesions"
Riton optional |
|
|
enfuvirtide
|
"enfu - where it enters you": Injection site reaction - pain, erythema, nodule, cyst
Fusion inhibitor |
|
|
maraviroc (Selzentry)
|
"Mara smokes & drinks too much -> red face": Cough & upper RTI (c/o CCR5 on macrophages not working - macrophages in lung)
drinks = elevated liver enzymes (hepatotoxic), Red = rash, fever CCR5 inhibitor |
|
|
raltegravir (Isentress)
|
"Jock named Ralter - drinks and lifts too much": elevated liver enzymes
rhabdomyolysis (muscle brkdwn) -> myopathy (muscle wkness, cramps, stiff, spasm) Integrase Strand Transfer Inhibitor (InSTI) |
|
|
Atripla
|
Highly Active Antiretroviral Therapy (HAART)
(tenofovir + emtricitabine + efavirenz); "Eva tripped and needed TEN EMTs for her HAART" |
