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15 Cards in this Set
- Front
- Back
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What does HAART stand for?
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highly active antiretroviral therapy
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What does NRTI stand for?
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nucleoside reverse transcriptase inhibitor
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What is CD4?
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a type of T lymphocyte
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How many people worldwide have HIV?
How many people are unaware of their status? |
*40 million worldwide
*25% |
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___% of those people diagnosed with HIV already meet the criteria for AIDS.
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40
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What is the avg CD4 cell count at initiation of ART?
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187 cells/mm
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Among women, what are the majority of cases of HIV due to?
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heterosexual contact
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What are some risk factors for HIV?
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*IVDA or sex w/those that use
*unprotected, at-risk sexual behavior (ie. MSM, sex workers) *other STDs *tattoos or body piercing w/contaminated equipment *occupation exposure *maternal HIV transmission to newborns |
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What is the 6 stage process of the pathophys of HIV?
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1-binding & fusion
2-reverse transcription 3-integration 4-transcription 5-assembly 6-budding |
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What is HIV?
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a retrovirus -- uses reverse transcriptase to convert RNA to DNA; uses genetic material of host cells for viral replication
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During step 1, binding & fusion, what does HIV do?
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binds w/receptors on surface of CD4 lymphocyte & fuses. Virus then releases genetic material which enters host cell.
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What does reverse transcriptase do?
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converts single strand viral RNA into double stranded viral DNA
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What does integrase do?
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hides the HIV DNA w/in the host DNA- "provirus"
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What happens during transcription?
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HIV genetic material constructed & HIV mRNA is formed
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What does protease do?
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cuts long HIV proteins
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