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31 Cards in this Set
- Front
- Back
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Abacavir
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NRTI: Ziagen
300mg bid, 600mg QD SE-Hypersensitivity, Only NRTI with no renal adjustment |
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Didanosine
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NRTI: Videx
>60kg 400mg QD,<60kg 250mg QD TAKE ON EMPTY STOMACH AE: Pancreatitis and peripheral Neuropathy |
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Emtricitabine
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NRTI:Emtriva
200mg or 240 mg (24mL) Solution QD AE: Hyperpigmentation (palms/feet) |
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Lamivudine
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Epivir
300mg QD or 150 BID Well tolerated |
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Stavudine
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Zerit
>60kg: 40mg bid <60kg: 30mg bid AE:Peripheral neuropathy,lipoatrophy |
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Tenofovir
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Nucleotide RTI: Viread
300mg QD AE: nephrotoxicity, flatulence |
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Zidovudine
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NRTI: Retrovir
300mg bid, 200mg tid AE: anemia, myopaathy Use in pregnant women and neonates, decr. vertical transmission |
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NRTIs
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Inhibit reverse transcriptase enzyme by mimicking natural nucleotides.
Black Box warning for Lactic Acidosis SE of fatigue,ha nausea Take with or without food except didanosine |
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Delavirdine
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NNRTIs: Rescriptor
Rarely used |
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Efavirenz
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Sustiva
600mg QHS AE: Vivid dreams, drowsiness TAKE ON EMPTY STOMACH false +ve canaboid test -ve effect on lipid profile |
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Etravirine
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NNRTI: Intelence
200mg BID AE: Rash TAKE WITH FOOD -higher resistance Ci with unboosted PIs |
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Nevirapine
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NNRTI: Viramune
200mgQD *14days then 200 BID AE: Rash Hepatotoxicity ( do not use if cd4 >250 F and >400men) ONLY ART initiated at lower dose |
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NNRTIs
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Inhibit reverse transcriptase by binding directly to the enzyme.
CYP450 many drug interactions |
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Protease Inhibitors
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Take with food to increase tolerability(Nelfinavir to increase absoption)
Increase ther risk of bleeding in pts with hemophilla -Associated with long term metabolic effects ( triglycerides, blood glucose, and fat redistribution (lipodystrophy)) -Inhibitors of CYP3A4 except tipranavir which is an inducer -With PDE5 need to decr, dose and interval - sulfa moiety in fosamprenavir, darunavir, and tipranavir be aware of sulfonamide allergy |
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Atzanavir
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PI: Reyataz
400mg QD or 300mg w 100RTV QD AE: Hyperbilirubinemia, Nephrolithiasis (kidney stones) DI: antacids- 2hrs before or 1 hr after atzanavir, H2-blocker= simultaneously or <10hr after boosted atzanavir, PPI+ not recommended in tx experienced pts. Max dose = 20mg qd of prilosec 12 hrs before /after -Increase fluid intake to risk of nephrolithiasis |
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Darunavir
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Prezista
800mg + RTV100 QD pt naive only 600mg +RTV100 BID |
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Fosamprenavir
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PI: Lexiva
1400mg bid or 1400mg + RTV 100-200 mg QD (Pt naive only) 700mg+ RTV100 BID |
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Indinavir
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Crixivan
800mg +RTV 100-200 BID AE: Hyperbilirubinemia , nephrolithiasis |
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Lopinavir/ritinovir
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PI: Kaletra
200/50 or 100/25 2tabs bid or 4 tabs qd (pt naive only) |
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Nelfinavir
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PI: Viracept
1250mg bid, 750 tid ONlY PI that cannot be boosted with RTV |
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Ritinovir
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PI:Norvir
100-200 mg with other PIs AE: Gastrointestinal, lipid effects -used to inhibit metabolism of other PIs(cyp3A4 inhibitor) |
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Saquinavir
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Invirase
1000mg with 100mg RTV bid |
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Tipranavir
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Aptivus
500mg with RTV200mg bid CYP3A4 inducer therefore given with a higher dose of RTV |
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Maraviroc
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CCR5:
Selzentry 150-600mg BID AE: Rash, Cough fever, Hepatotoxicity Testing for tropism assay required beforeinitiation |
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Enfuvirtide
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Fusion Inhibitor
Fuzeon 90mg SC BID AE: Injection site rxn unused doses can be refrigerator (use within 24hrs) |
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Raltegravir
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Integrase inhibitor
Isentress 400mg bid AE: usually well tolerated, CPK elevation, nausea, HA with Rifampin increase to 800mg BID |
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Zidovudine and Lamivudine
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Combivir
300/150 mg BID |
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Zidovudine, Lamivudine, and abacavir
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Trizivir
300/150/300 mg BID |
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Lamivudine and abacavir
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Epzicom
300/600 mg QD |
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Tenofovir, emtricitabine, efavirenz
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Atripla
300/200/600 QHS |
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Tenofovir, emtricitabine
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Truvada
300/200 mg QD |
