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47 Cards in this Set

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What are the three components of an extracellular matrix?
Fibers
Ground Substance
Tissue Fluid
Most CT originates from __?
mesoderm
What occupies the space between the cells of CT?
Ground substance
GAGs make up the __?
Ground Substance
Four groups of GAGs.
1. Hyaluronic Acid
2. Chonditin Sulfate/ Dermatan Sulfate
3. Heparin Sulfate
4.Keratin Sulfate
Hyaluronic Acid
Component of?
Resists?
Component of cartilage, synovial fluid, vitreous humor

Resists compression
Chondritin sulfate
Component of?
Hyaline and elastic cartilage, arteries
Dermatan sulfate
component of?
skin, blood vessels, heart valves
Heparin Sulfate
Associated with?
Reticular fibers, blood vessel walls, many cell surfaces
Heparin
lungs, skin, liver, mast cells
Keratin sulfate
where?
Found in cornea
nucleus pulposus
cartilage
Macromolecules that bind ECM components to each other and to cell integrins (like glue)
Glycoproteins
Mediates diffusion of oxygen and nutrients between vasculature and cells.
Glycoproteins
What are the 4 types of ECM Glycoproteins?
1. Fibronectin
2. Laminin
3. Chondronectin
4. Osteonectin
Fibronectin
mediates?
Binds to?
Found where?
Mediates cell adhesion to ECM.
Binds to integrin. (Hemidesmosomes)
Found in CT cells and cell surfaces
The plasma form of this glycoprotein is dissolved in the blood and involved in clotting and wound healing.
Fibronectin
This ECM glycoprotein binds collagen, heparin, and mediates cell adhesion to ECM by binding to integrins.
Fibronectin
Laminin
Component of?
Component of basement membranes.
Chondronectin function?
Attaches chondrocytes to Type II Collagen
This ECM glycoprotein functions in development and maintenance of cartilage.
Chondronectin
Osteonectin
where?
what does it do?
Found in bone.
Links minerals to Type I Collagen.
This ECM glycoprotein influences calcification by inhibiting crystal growth.
Osteonectin
What are the three types of CT Fibers?
1. Collagen Fibers
2. Reticular Fibers
3. Elastic Fibers
Type I Collagen
where?
who?
BONE, Dense and Loose CT, Tendons, Fascia

Fibroblasts, Osteoblasts, Odontoblasts
Type II Collagen
Where?
Who?
COLLAGEN
Hyaline and Elastic Cartilage (Nucleus Pulposus, Epiphyseal Plate)

Chondroblasts
Type III Collagen
Where?
Who?
RETICULAR FIBERS (provide elasticity)
liver, lymph nodes, CT, vessels

Schwann cells, hepatocytes, Smooth muscle cells
Type IV and VII Collagen
Where?
Who?
BASEMENT MEMBRANE

Connects basement membrane of epithelium to CT.
Endothelial and epithelial cells, muscle cells, fibroblasts
Type V Collagen
similar to?
formed as?
where?
Similar to Type I.
Formed as thin layers around cells.
Muscle and tendon sheaths, placenta.
Ehlers-Danlos Syndrome
CT disorder.
Affects collagen structure and function causing instability. Super flexible.
What fibers are twisted together to make an elastic fiber?
Elastin and Fibrillin
Marfan Syndrome
A genetic disorder affecting CT. Dereditary defect of Elastin and Fibrillin fibers (which make up elastic fibers).
Fibroblasts
arise from?
make?
arise from mesenchymal cells

spindle shaped, make ECM components
Adipocytes
arise from?
function?
arise from mesenchymal cells

fat storage
Macrophages originate as ? where?
Macrophages differentiate from monocytes which come from bone marrow. (travel in blood to different places to mature into different macrophage phenotypes)
Mast Cells
arise from myeloid stem cells during hematopoiesis
Plasma Cells
placed strategically around the body to make immunoglobins
Lymphocytes arise from? types?
arise from lymphoid stem cells in bone marrow.

Tcells and Bcells
Neutrophils are the first cell in ?
First cell that appears in inflammatory reaction. Phagocytic.
Eosinophils are important for?
important for parasite immune response.
Cells > Fibers
Loose CT
Types of Loose CT
Reticular Tisue
Adipose Tissue
Reticular Tissue
fibers?
where?
Type III FIbers (reticular)
Liver, bone marrow, endocrine glands
Fibers > Cells
Dense CT
3 types of Dense CT
Dense Regular
Dense Irregular
Elastic Tissue
Dense regular CT
fiber bundle arrangement?
contain?
where?
Fiber bundles arranged in uniform manner.
Contain fibroblasts and fibrocytes.
Tendons and ligaments.
Dense Irregular CT
fiber bundles?
contains?
where?
Fiber bundles have no particular orientation so they are very strong.
Contains fibroblasts, macrophages.
Found in dermis, organ capsule, deep fascia
Elastic Tissue
fiber arrangement?
contains?
examples?
Sparse collagen fibers but LOTS of elastic fibers arranged in uniform OR irregular pattern.
Some fibroblasts present.
Ligamentum flavum and aorta.