Histology - Lecture 1 - Liver And Gall Bladder

Front 1

What are some functions of the Liver?

Back 1

1-3
-Filter Blood
-Recycle Blood
-Detoxification
-Production of Bile - Exocrine
-Storage and Conversion of some Vitamins
-Glycogen Storage and Synthesis

Front 2

What are the Sources of Blood for the Liver? In what proportions?

Back 2

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-Hepatic Portal Vein - 75%
-Hepatic Portal Artery - 25%

Front 3

Into what portion of the Liver does Blood Flow from the Hepatic Portal Vein and Hepatic Artery join together?

Back 3

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-Sinusoids

Front 4

Where does Blood drain to in the liver?

Back 4

Central Vein

Front 5

What surrounds the Central Venule?

Back 5

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-Sinusoids
-Hepatocytes

Front 6

What do the Hepatic Portal Vein, Hepatic Arteriole, and Bile Duct form?

Back 6

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Portal Triad

Front 7

What Shape do the Portal Triads make with the Central Vein?

Back 7

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Hexagonal

Front 8

How can you tell the difference between a Portal Triad and Central Venule?

Back 8

1-8
-Central Venules are Larger
-Triads will 3 things - look in higher magnification

Front 9

What Separates the Lobules of the Liver?

Back 9

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Connective Tissue

Front 10

What lines the Lumen of the Central Venule? How many layers of muscle do we find around it?

Back 10

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-Squamous Epithelium
-No Muscle layers

Front 11

Where does BIle Collect?

Back 11

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-Bile Ducts
-Portal Triad

Front 12

In which Direction is Bile Flow?

Back 12

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-Opposite of Blood Flow

Front 13

How many layers of muscle surround a Hepatic Arteriole? What type of muscle is this?

Back 13

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-3
-Smooth

Front 14

What are the 3 Different ways to Organize Hepatic Lobules? Describe each one.

Back 14

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-Classical Lobule - Focus on the Blood Draining to the Central Vein
-Portal Lobule - Exocrine Oriented; focuses on the movement of Bile towards the Portal Triad
-Hepatic Acinus - Focuses on the Blood Supply as related to the Triads

Front 15

What happens to O2 concentration as we move towards the Central Venule in a classical lobule? Why?

Back 15

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-Decreases
-Mixing of Blood from Hepatic Portal Vein and Hepatic Artery

Front 16

Where are Hepatocytes found?

Back 16

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-In the Parenchyma of Liver

Front 17

What types of Cells Store Vitamin A in the Liver? Where are they found?

Back 17

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-Ito Cells
-Under Hepatocytes

Front 18

What are Kupffer Cells? Where are they found? What do they do?

Back 18

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-Macrophages
-In Sinusoids of the Liver
-Phagocytose RBCs

Front 19

What is the Space of Dissi?

Back 19

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-Space between Hepatocyte Microvilli and Blood Plasma
-Acts as a Buffer Zone

Front 20

What do Hepatocytes do?

Back 20

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-Produce Bile and secrete it to the Canaliculi
-Store Glycogen

Front 21

Why do Hepatocytes have lots of ER (S and R), Peroxisomes, and Mitochondria?

Back 21

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-They are doing a lot of work
-Synthesizing Albumin, Fibrinogen, Lipoproteins, Steroids/Lipids
-Involved in Metabolism and Detoxification
-Need energy for all this shit

Front 22

Where are Kupffer Cells Found?

Back 22

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-Space of Dissi, right next to Endothelium
-Sinusoids (Usually)

Front 23

What do the Mucosa of the Gall Bladder Look like?

Back 23

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-Highly Folded

Front 24

How does the Gallbladder concentrate Bile?

Back 24

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-Removes Water by using the Sodium/Potassium Pump

Front 25

Describe the Flow of Secretions in the Pancreas.

Back 25

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-Acinus
-Intercalated Duct
-Intralobular Duct
-Interlobular Duct
-Pancreatic Duct

Front 26

When Secretions leave an Acinus in the Pancreas, where do they go?

Back 26

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-Centroacinar Cell

Front 27

What do Islets of Langerhans look like when stained?

Back 27

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-Light, Diffuse