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48 Cards in this Set
- Front
- Back
Fxns of the kidney
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excretion of waste
elimination of foreign waste regulation of body H2O regulation of salts control Acid/Base |
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Fxns of kidney: Endocrine
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affects blood formation (erythropoietin)
affects blood pressure (renin) Vitamin D synthesis |
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Fxns of kidney: Reproductive
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conveys semen in male urethra
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3 Processes of Urine Formation?
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Filtration: ultrafiltration of plasma formed
Secretion: substances are moved into filtrate Reabsorption: substances moved out of filtrate into renal interstitium |
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Glomerulus
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spherical arrangement of fenestrated capillaries
found in proximal end of kidney tubule fluid is glomerular filtrate |
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Structure of Kidney:
Renal Hilum |
vertical slit on concave border
entrance of renal artery, vein, lymphatics and nerves as well as ureter |
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Structure of Kidney:
Cortex |
outer portion of kidney
has columns, pyramids, medullary rays |
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Structure of Kidney:
Lobes |
6-18 per kidney
consists of one medullary pyramid and cortical cap that surrounds it |
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Structure of Kidney:
Nephron |
functional unit of kidney
proximal end contains capillaries and supporting cells |
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Structure of Kidney:
Bowmans Capsule |
double-layered cup that surround the nephron
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Structure of Kidney:
parts of Nephron |
PCT and PST
DST and DCT macula densa |
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Structure of Kidney:
vascular pole of nephron |
entrance and exit of afferent and efferent arterioles
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Structure of Kidney:
Urinary pole of Nephron |
continuous w/ first segment of nephron, starts filtration here
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Bowmans Capsule: Inner Layer
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"visceral layer"
made up of podocytes |
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Bowmans Capsule: Podocytes
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modified epithelial cells
have pedicles, or feet -filtration slits b/t feet |
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Bowmans Capsule: Filtration Slits
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b/t pedicles of podocytes
bridged by thin filtration slit membrane |
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Bowmans Capsule: Filtration Barrier
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made of capillary endothelium, podocytes, and glomerular basement membrane
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Bowmans Capsule: Glomerular Basement Membrane
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space b/t endothelium and podocytes
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Bowmans Capsule: outer layer
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"parietal layer", simple squamous
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Bowmans Capsule: Mesangial Cells
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synthesize a supportive matrix for the glomerular capillaries
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Bowmans Capsule: Extraglamerular Mesangial Cells
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found outside renal corpuscle along vascular pole
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Mesangial Cell Fxns
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phagocytosis of particles in basal lamina
structural support regulates blood flow Secrete IL-1 and PDGF |
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What makes up the Juxtoglamerular Apparatus?
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Macula Densa
Juxtaglomerular Cells Extraglamerular Mesangial Cells |
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Macula Densa
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made of Distal Convoluted Tubules that have become taller (columnar)
directly by afferent and efferent arterioles |
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Juxtaglomerular Cells
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modified SM cells that have secretory products
granules contain renin |
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Renin Fxn
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catalyzes cleavage of Angiotensin 1 from angiotensinogen
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Angiotensin 2 Fxns
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increase BP by constricting arterioles
stimulates release of Aldosterone |
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Proximal Thick Segment:
PCT Epithelium |
simple cuboidal w/ brush border
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Proximal Thick Segment:
Fxns |
pH modification
AA resorption Na/K ATPase Aquaporins present |
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Thin Segment:
Countercurrent system |
responsible for producing hypertonic environment
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Thin Segment:
Ascending thin |
impermeable to water
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Thin Segment:
descending thin |
permeable to water
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Distal Thick Segment:
what are the parts |
distal straight tubule
macula densa DCT |
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Distal Thick Segment:
DCT |
simple cuboidal, no brush border
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Collecting Ducts
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lined w/ cuboidal to columnar epithelium
"papillary ducts" near apex |
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Collecting Ducts:
Light (principle) cell |
secretes K, resorbs Sodium
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Collecting Ducts:
Dark (intercalated) cell |
secrete HCO3 and H
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What is the cell that is primarily affect by ADH regulation?
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Collecting duct cells
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Collecting Ducts: single cilia
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sensory fxn
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Circulation of Kidney
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Renal-->Interlobar-->Arcuate-->Interlobar-->afferent arterioles-->glomerular capillaries-->efferent arteriole-->peritubular capillaries
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Kidney Circulation:
Vasa Recta |
thin capillary that go into medulla and loop back
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Ureter
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uses peristaltic contraction
3 SM layers Transitional Epithelium |
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Urinary Bladder:
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Transitional Epithelium
contains pinocytotic vesicles and fusiform-shaped vesicles |
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Urinary Bladder:
outside covering |
peritoneum superiorly, serosa
elsewhere adventitia |
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Urethra: what are the 3 parts?
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prostatic, membranous, and penile
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Prostatic Urethra:
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transitional epithelium
contains ejaculatory ducts |
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Membranous Urethra:
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penetrates urogenital diaphragm
pseudostratified columnar |
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Penile Urethra:
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pseudostratified columnar-->stratified squamous near opening
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