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115 Cards in this Set
- Front
- Back
blood distribution amongst vessels (most to least)
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- systemic veins and venules (blood reservoirs)
- systemic arteries and arterioles - pulmonary vessels - heart - systemic capillaries |
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3 main components of tunica intima
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- endothelium+ basal lamina
- subendothelial layer - internal elastic lamina |
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4 components of tunica media
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smooth muscle- concentric & helical layers
elastic fibers & elastic lamellae reticular fibers pericytes (in capillaries and post-capillary venules) |
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(general) 2 components of tunica adventita
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collagen and elastic fibers
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blood vessel innervation
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sympathetic and parasympathetic to control blood vessel size
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makes up the tunica media of capillaries
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pericytes outside of the basal lamina
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contain contractile proteins
can transform into other cell types participate in angiogenesis act as stem cells in wound environment |
pericytes
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3 components of capillaries
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endothelium (w/ tight junctions)
basal lamina pericytes |
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3 types of capillaries
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continuous- somatic
fenestrated- visceral discontinuous-sinusoidal |
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capillary type found in muscle, CT, exocrine glands, nerve tissue, blood-brain barrier
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continuous-somatic capillaries
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endothelial cells of continuous capillaries typically have lots of these
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pinocytotic vesicles (except for blood-brain barrier cells)
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2 types of fenestrated capillaries and where they're found
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diaphragm- kidney, intestine, endocrine glands
non-diaphragm- renal glomerulus |
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location of discontinuous capillaries
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liver and hematopoietic organs (bone marrow)
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large diameter capillaries
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discontinuous capillaries
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arterioles with discontinous layer of smooth muscle and their purpose
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metarterioles
- constriction slows down circulation - helps maintain pressure differences between arterial and venous systems |
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complete ring of smooth muscle at junction of metarterioles and capillaries and its purpose
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precapillary sphincters
- completely stops blood flow into capillaries |
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organs with portal systems
- arterial system: -venous system: |
arterial system: kidney glomerulus
venous system: liver |
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lacking in arterioles
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external elastic lamina
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have thin tunica intima and subendothelial layer
thin adventita |
arterioles
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4 characteristics of muscular arteries
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- prominent internal elastic laminae
- up to 40 layers of smooth muscle in media - external elastic laminae - vasa vasora |
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vessels with a thick tunica intima and subendothelial layers
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elastic arteries
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typical tunica media of elastic arteries
tunica adventitia? |
40-70 concentric elastic laminae + smooth muscle cells sandwiched in between
underdeveloped t. adventitia |
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in arteries ______ is thickest layer
in veins ________ is thickest layer |
tunica media
tunica adventita |
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3 characteristics of venules
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thin walls
pericytes in small postcapillary venules usually accompany arteriole |
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characterized by thick tunica media and well-developed tunica adventitia w/ some smooth muscle layers
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large veins
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lymphatic capillaries have
______ endothelium ______ fenestrations ______ zonula occludens _______ basal lamina _______ anchor vessels to surrounding CT |
thin endothelium
no fenestrations no zonula occludens between cells discontinuous basal lamina microfibril anchors |
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2 large lymph vessels
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thoracic duct
right lymphatic duct |
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3 components of tunica intima of heart and other name for it
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- endothelium
- thin layer of loose CT - subendocardial layer of purkinje fibers aka endocardium |
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2 components of tunica media of heart and other name for it
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- contractile cardiac muscle cells
- impulse-generating and conducting muscle cells (NOT purkinje) myocardium |
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components of tunica adventitia of heart and other name for it
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- mesothelium
-CT layer containing coronary vessels purkinje fibers lymphatic vessels adipocytes epicardium |
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provides structural support of valves
acts as electrical insulator between atria and ventricles attachment of cardiac muscle |
fibrous cardiac skeleton
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location of SA node and AV node
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in right atrium at entrance of superior VC
in septal wall of right atrium next to tricuspid valve |
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order of cardiac conduction system
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1. SA node
2. AV node 3. bundle of His 4. right and left bundle branches 5. purkinje fibers |
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7 functions of skin
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barrier protection
immunological defense/wound healing homeostasis conveys sensory info to nervous sytem endocrine function: Vit D3 exocrine function: secretion via sweat, sebaceous and apocrine glands dermatoglyphics |
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embryonic origins of skin (epidermis, dermis and hypodermis)
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epidermis: ectoderm
dermis and hypodermis: mesoderm |
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skin derivatives
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hair and hair follicles
sweat glands and sebaceous glands nails mammary glands |
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types of epidermis and where they're found
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stratified squamous keratinized
stratified squamous nonkeratinized (mouth) stratifed cuboidal (sweat glands) stratified columnar (conjuctiva) |
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cells of the epidermis
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keratinocytes
melanocytes langerhans cells Merkel's |
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5 layers of the epidermis
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s. basale
s. spinosum s. granulosum s. lucidum s. corneum |
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junctions of cells in s. spinosum
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desmosomes (cells shrink away from them, look prickly)
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excreted to create the waterproof barrier of skin
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membrane-bound lamellar granules
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2 granule types in s. granulosum and which is membrane bound
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- basophilic keratohyalin (not)
- lamellar granules (membrane bound) |
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layer that's more apparent in thick skin
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s. lucidum
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melanocytes are derived from
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neural crest cells
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two types of melanin and the color they produce
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eumelanin (dark brown)
pheomelanin (red hair) |
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where are melanocytes found?
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resting on basal lamina
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dendritic cell in stratum spinosum
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langerhans cells
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purpose of langerhans cells
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antigen presenters (by extending dendrites through tight junctions to detect/bind); play a role in allergies
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langerhans cells are derived from
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bone marrow
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where langerhans cells are especially prevalent
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oral and vaginal epithelia
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type of granules in langerhans cells
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birbeck's granules
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modified epidermal cell that binds to other cells via desmosomes
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merkel's cells (langerhans and melanocytes don't bind via desmosomes)
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mechanoreceptor found in thick skin with acute sensory perception
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merkel's cells
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skin cell with a diffuse neuro-endocrine system related with dense neurosecretory granules in cytoplasm
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merkel's cells
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tissue/fibers of the papillary layer of dermis
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loose CT (type III collagen)
anchoring fibrils (type VII) elastic fibers: oxytalan and elaunin |
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tissue/fibers of reticular layer of dermis
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dense irregular CT (type I collagen)
thick elastic fibers |
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cells of the dermis
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fibroblasts, mast cells, macrophages, adipocytes
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2 things that contribute strength to dermis/epidermis junction
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- rete pegs and dermal papillae
- hemidesmosomes |
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dermal ridges of fingerprints tend to have ______ arrangements with _______ between them
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parallel with dermal papillae between them
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thicker and less cellular layer of dermis
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reticular
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4 things found in the hypodermis
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loose CT
large blood vessels adipose tissue pacinian corpuscles |
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where pacinian corpuscles are found
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at dermo-hypodermal junction
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4 skin sensory receptors
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free nerve endings in epidermis
merkel's ending pacinian corpuscles meissner corpuscles |
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where meissner corpuscles are found
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dermal papillae
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where metarterioles and sphincters are found in skin
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in papillary loops (can slow/ shunt blood away from periphery to keep core temp up)
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simple branched gland
simple coiled gland modified sweat gland |
sebaceous gland
sweat glands mammary glands |
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2 types of sweat glands
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eccrine and apocrine
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where sebaceous glands aren't found
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thick skin (no hair follicles)
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sebaceous glands have this type of secretion
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holocrine
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eccrine sweat glands are found everywhere but
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lips and glans penis
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3 modified sweat glands
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ceruminous (wax) glands
mammary glands glands of moll (margins of eyelids) |
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glands with dark secretory cells vs light secretory cells and what do they produce
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eccrine
- dark = mucous-rich substance - clear= watery secretions, no granules |
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ducts of glands lined by
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bistratified cuboidal epithelium
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cells that surround secretory portion of glands
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myoepithelial cells
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eccrine sweat glands are responsible for
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thermal regulation
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location of apocrine sweat glands
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axilla, areola/nipple, circumanal, external genitalia
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where apocrine glands release their product
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into hair follicles above sebaceous glands
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have larger and wider lumens that merocrine glands
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apocrine sweat glands
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muscle that makes hair stand up
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arrector pili muscles
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the hair bulb is a
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dermal papilla
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the nail bed is what layers of epidermis
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s. basale and spinosum
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purpose of conducting portion of the respiratory system
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- conduit for movement of air in and out
- conditioning of inspired air (filter, moistening, warming) |
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differentiates conducting from respiratory zone
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presence of alveoli in respiratory zone
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how to tell bronchi/trachea apart from bronchioles
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presence of cartilage
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components of trachea mucosa layer
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respiratory epithelium, lamina propria (loose CT), elastic fibers
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components of trachea submucosa
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dense irregular CT; fibroelastic
mucous and seromucous glands, venules, smooth muscle |
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components of trachea adventitia
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16-20 hyaline cartilage C-shaped rings
anchors trachea to neck tissues |
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cells of bronchioles that secrete protein to protect lining
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clara cells
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in bronchioles that may be chemoreceptive and aid in cell renewal
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neuroepithelial bodies
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bronchi smooth muscle is ________ while bronchiole smooth muscle is __________
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crisscrossing spirals (more abundant)
helical orientation (less abundant) |
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mixture of terminal bronchiole epithelium and alveoli
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respiratory bronchioles
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makes up alveolar septa
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2 squamous epithelial layers + interstitium
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present in interstitium of alveoli
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capillaries
elastic and reticular fibers (loose CT) basement membrane fibroblasts, mast cells, macrophages, leukocytes |
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cells that line the alveolar surface
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type 1 pneumocytes
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abundant in type 1 pneumocytes
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- pinocytotic vesicles
- desmosomes and occluding junctions |
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where type II pneumocytes are located (how much area do they cover + where are they)
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3% of alveolar surfaces
small groups at angles of alveolar septal walls |
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secretory vesicles called _______ are located in this cell type and produce surfactant
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lamellar bodies
in type II pneumocytes |
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makes up the air-blood barrier
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- surface-lining and cytoplasm of alveolar cells
- fused basal laminae of alveolar and endothelial cells -supporting elastic and reticular fibers |
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3 lung circulations
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functional (pulmonary)
systemic (bronchial) circulation pulmonary lymph vessels |
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follow and branch with bronchial tree
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pulmonary arteries
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pulmonary vessel (artery or vein) with thicker adventitia
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pulmonary veins (thin intima and rich elastic fiber network)
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bronchial veins drain what
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only the connective tissue of the hilar region of the lungs (most blood going to lunchs from bronchial arteries leave via pulmonary veins)
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bronchiolar arteries distribute oxygenated blood to the lung to to this point
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respiratory bronchioles
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when conducting and respiratory circulations meet, vessels carrying __________ blood anastomose with the pulmonary _____
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deoxygenated blood (that just supplied the lung tissue)
anastomose with the pulmonary vein (containing oxygenated blood) |
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pulmonary lymphatic vessels follow _____ and _______
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bronchi and pulmonary vessels
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primary cause of cytisic fibrosis
epithelia of which respiratory structures contribute to the disease? one factor leading to respiratory infections |
- genetic
- bronchioles - defective Cl- channel, increased water reabsorption, can't clear thick mucous stuff is stuck in, trapped |
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main characteristic of emphysema?
what lumens become narrowed? walls of what are destroyed? |
- permanent enlargement of air spaces distal to terminal bronchioles
- bronchioles are narrowed - alveolar walls destroyed |
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aorta is an example of what
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an elastic artery
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which veins have valves?
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small and medium veins have valves, large ones do not
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vessel with numerous valves
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lymph vessels (more than veins)
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epidermis layer with horny cells that have _______ plasma membranes filled with fibrillar and amorphous proteins
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s. corneum- thickened plasma membranes
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present in cytoplasm of s. corneum
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keratin
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2 types of cells in sebaceous glands and their nucleus type
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basal cells- spherical nucleus (cells have glycogen and lipids)
larger round cells- picnotic nuclei (secreted thru holocrine sec.) |
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parts of hair from inside out
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cortex -->medulla --> cuticle --> internal root sheath --> external root sheath --> glassy membrane
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cells of respiratory mucosa
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- ciliated columnar
- mucous goblet - brush cells - basal (short) cells - small granule cells |