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115 Cards in this Set

  • Front
  • Back
blood distribution amongst vessels (most to least)
- systemic veins and venules (blood reservoirs)
- systemic arteries and arterioles
- pulmonary vessels
- heart
- systemic capillaries
3 main components of tunica intima
- endothelium+ basal lamina
- subendothelial layer
- internal elastic lamina
4 components of tunica media
smooth muscle- concentric & helical layers
elastic fibers & elastic lamellae
reticular fibers
pericytes (in capillaries and post-capillary venules)
(general) 2 components of tunica adventita
collagen and elastic fibers
blood vessel innervation
sympathetic and parasympathetic to control blood vessel size
makes up the tunica media of capillaries
pericytes outside of the basal lamina
contain contractile proteins
can transform into other cell types
participate in angiogenesis
act as stem cells in wound environment
pericytes
3 components of capillaries
endothelium (w/ tight junctions)
basal lamina
pericytes
3 types of capillaries
continuous- somatic
fenestrated- visceral
discontinuous-sinusoidal
capillary type found in muscle, CT, exocrine glands, nerve tissue, blood-brain barrier
continuous-somatic capillaries
endothelial cells of continuous capillaries typically have lots of these
pinocytotic vesicles (except for blood-brain barrier cells)
2 types of fenestrated capillaries and where they're found
diaphragm- kidney, intestine, endocrine glands
non-diaphragm- renal glomerulus
location of discontinuous capillaries
liver and hematopoietic organs (bone marrow)
large diameter capillaries
discontinuous capillaries
arterioles with discontinous layer of smooth muscle and their purpose
metarterioles
- constriction slows down circulation
- helps maintain pressure differences between arterial and venous systems
complete ring of smooth muscle at junction of metarterioles and capillaries and its purpose
precapillary sphincters
- completely stops blood flow into capillaries
organs with portal systems
- arterial system:
-venous system:
arterial system: kidney glomerulus
venous system: liver
lacking in arterioles
external elastic lamina
have thin tunica intima and subendothelial layer
thin adventita
arterioles
4 characteristics of muscular arteries
- prominent internal elastic laminae
- up to 40 layers of smooth muscle in media
- external elastic laminae
- vasa vasora
vessels with a thick tunica intima and subendothelial layers
elastic arteries
typical tunica media of elastic arteries

tunica adventitia?
40-70 concentric elastic laminae + smooth muscle cells sandwiched in between

underdeveloped t. adventitia
in arteries ______ is thickest layer

in veins ________ is thickest layer
tunica media

tunica adventita
3 characteristics of venules
thin walls
pericytes in small postcapillary venules
usually accompany arteriole
characterized by thick tunica media and well-developed tunica adventitia w/ some smooth muscle layers
large veins
lymphatic capillaries have

______ endothelium
______ fenestrations
______ zonula occludens
_______ basal lamina
_______ anchor vessels to surrounding CT
thin endothelium
no fenestrations
no zonula occludens between cells
discontinuous basal lamina
microfibril anchors
2 large lymph vessels
thoracic duct
right lymphatic duct
3 components of tunica intima of heart and other name for it
- endothelium
- thin layer of loose CT
- subendocardial layer of purkinje fibers

aka endocardium
2 components of tunica media of heart and other name for it
- contractile cardiac muscle cells
- impulse-generating and conducting muscle cells (NOT purkinje)

myocardium
components of tunica adventitia of heart and other name for it
- mesothelium
-CT layer containing
coronary vessels
purkinje fibers
lymphatic vessels
adipocytes

epicardium
provides structural support of valves
acts as electrical insulator between atria and ventricles
attachment of cardiac muscle
fibrous cardiac skeleton
location of SA node and AV node
in right atrium at entrance of superior VC

in septal wall of right atrium next to tricuspid valve
order of cardiac conduction system
1. SA node
2. AV node
3. bundle of His
4. right and left bundle branches
5. purkinje fibers
7 functions of skin
barrier protection
immunological defense/wound healing
homeostasis
conveys sensory info to nervous sytem
endocrine function: Vit D3
exocrine function: secretion via sweat, sebaceous and apocrine glands
dermatoglyphics
embryonic origins of skin (epidermis, dermis and hypodermis)
epidermis: ectoderm
dermis and hypodermis: mesoderm
skin derivatives
hair and hair follicles
sweat glands and sebaceous glands
nails
mammary glands
types of epidermis and where they're found
stratified squamous keratinized
stratified squamous nonkeratinized (mouth)
stratifed cuboidal (sweat glands)
stratified columnar (conjuctiva)
cells of the epidermis
keratinocytes
melanocytes
langerhans cells
Merkel's
5 layers of the epidermis
s. basale
s. spinosum
s. granulosum
s. lucidum
s. corneum
junctions of cells in s. spinosum
desmosomes (cells shrink away from them, look prickly)
excreted to create the waterproof barrier of skin
membrane-bound lamellar granules
2 granule types in s. granulosum and which is membrane bound
- basophilic keratohyalin (not)

- lamellar granules (membrane bound)
layer that's more apparent in thick skin
s. lucidum
melanocytes are derived from
neural crest cells
two types of melanin and the color they produce
eumelanin (dark brown)
pheomelanin (red hair)
where are melanocytes found?
resting on basal lamina
dendritic cell in stratum spinosum
langerhans cells
purpose of langerhans cells
antigen presenters (by extending dendrites through tight junctions to detect/bind); play a role in allergies
langerhans cells are derived from
bone marrow
where langerhans cells are especially prevalent
oral and vaginal epithelia
type of granules in langerhans cells
birbeck's granules
modified epidermal cell that binds to other cells via desmosomes
merkel's cells (langerhans and melanocytes don't bind via desmosomes)
mechanoreceptor found in thick skin with acute sensory perception
merkel's cells
skin cell with a diffuse neuro-endocrine system related with dense neurosecretory granules in cytoplasm
merkel's cells
tissue/fibers of the papillary layer of dermis
loose CT (type III collagen)
anchoring fibrils (type VII)
elastic fibers: oxytalan and elaunin
tissue/fibers of reticular layer of dermis
dense irregular CT (type I collagen)
thick elastic fibers
cells of the dermis
fibroblasts, mast cells, macrophages, adipocytes
2 things that contribute strength to dermis/epidermis junction
- rete pegs and dermal papillae
- hemidesmosomes
dermal ridges of fingerprints tend to have ______ arrangements with _______ between them
parallel with dermal papillae between them
thicker and less cellular layer of dermis
reticular
4 things found in the hypodermis
loose CT
large blood vessels
adipose tissue
pacinian corpuscles
where pacinian corpuscles are found
at dermo-hypodermal junction
4 skin sensory receptors
free nerve endings in epidermis
merkel's ending
pacinian corpuscles
meissner corpuscles
where meissner corpuscles are found
dermal papillae
where metarterioles and sphincters are found in skin
in papillary loops (can slow/ shunt blood away from periphery to keep core temp up)
simple branched gland
simple coiled gland
modified sweat gland
sebaceous gland

sweat glands

mammary glands
2 types of sweat glands
eccrine and apocrine
where sebaceous glands aren't found
thick skin (no hair follicles)
sebaceous glands have this type of secretion
holocrine
eccrine sweat glands are found everywhere but
lips and glans penis
3 modified sweat glands
ceruminous (wax) glands
mammary glands
glands of moll (margins of eyelids)
glands with dark secretory cells vs light secretory cells and what do they produce
eccrine
- dark = mucous-rich substance
- clear= watery secretions, no granules
ducts of glands lined by
bistratified cuboidal epithelium
cells that surround secretory portion of glands
myoepithelial cells
eccrine sweat glands are responsible for
thermal regulation
location of apocrine sweat glands
axilla, areola/nipple, circumanal, external genitalia
where apocrine glands release their product
into hair follicles above sebaceous glands
have larger and wider lumens that merocrine glands
apocrine sweat glands
muscle that makes hair stand up
arrector pili muscles
the hair bulb is a
dermal papilla
the nail bed is what layers of epidermis
s. basale and spinosum
purpose of conducting portion of the respiratory system
- conduit for movement of air in and out
- conditioning of inspired air (filter, moistening, warming)
differentiates conducting from respiratory zone
presence of alveoli in respiratory zone
how to tell bronchi/trachea apart from bronchioles
presence of cartilage
components of trachea mucosa layer
respiratory epithelium, lamina propria (loose CT), elastic fibers
components of trachea submucosa
dense irregular CT; fibroelastic
mucous and seromucous glands, venules, smooth muscle
components of trachea adventitia
16-20 hyaline cartilage C-shaped rings
anchors trachea to neck tissues
cells of bronchioles that secrete protein to protect lining
clara cells
in bronchioles that may be chemoreceptive and aid in cell renewal
neuroepithelial bodies
bronchi smooth muscle is ________ while bronchiole smooth muscle is __________
crisscrossing spirals (more abundant)

helical orientation (less abundant)
mixture of terminal bronchiole epithelium and alveoli
respiratory bronchioles
makes up alveolar septa
2 squamous epithelial layers + interstitium
present in interstitium of alveoli
capillaries
elastic and reticular fibers (loose CT)
basement membrane
fibroblasts, mast cells, macrophages, leukocytes
cells that line the alveolar surface
type 1 pneumocytes
abundant in type 1 pneumocytes
- pinocytotic vesicles
- desmosomes and occluding junctions
where type II pneumocytes are located (how much area do they cover + where are they)
3% of alveolar surfaces
small groups at angles of alveolar septal walls
secretory vesicles called _______ are located in this cell type and produce surfactant
lamellar bodies

in type II pneumocytes
makes up the air-blood barrier
- surface-lining and cytoplasm of alveolar cells
- fused basal laminae of alveolar and endothelial cells
-supporting elastic and reticular fibers
3 lung circulations
functional (pulmonary)
systemic (bronchial) circulation
pulmonary lymph vessels
follow and branch with bronchial tree
pulmonary arteries
pulmonary vessel (artery or vein) with thicker adventitia
pulmonary veins (thin intima and rich elastic fiber network)
bronchial veins drain what
only the connective tissue of the hilar region of the lungs (most blood going to lunchs from bronchial arteries leave via pulmonary veins)
bronchiolar arteries distribute oxygenated blood to the lung to to this point
respiratory bronchioles
when conducting and respiratory circulations meet, vessels carrying __________ blood anastomose with the pulmonary _____
deoxygenated blood (that just supplied the lung tissue)
anastomose with the pulmonary vein (containing oxygenated blood)
pulmonary lymphatic vessels follow _____ and _______
bronchi and pulmonary vessels
primary cause of cytisic fibrosis
epithelia of which respiratory structures contribute to the disease?
one factor leading to respiratory infections
- genetic
- bronchioles
- defective Cl- channel, increased water reabsorption, can't clear thick mucous stuff is stuck in, trapped
main characteristic of emphysema?

what lumens become narrowed?

walls of what are destroyed?
- permanent enlargement of air spaces distal to terminal bronchioles
- bronchioles are narrowed
- alveolar walls destroyed
aorta is an example of what
an elastic artery
which veins have valves?
small and medium veins have valves, large ones do not
vessel with numerous valves
lymph vessels (more than veins)
epidermis layer with horny cells that have _______ plasma membranes filled with fibrillar and amorphous proteins
s. corneum- thickened plasma membranes
present in cytoplasm of s. corneum
keratin
2 types of cells in sebaceous glands and their nucleus type
basal cells- spherical nucleus (cells have glycogen and lipids)

larger round cells- picnotic nuclei (secreted thru holocrine sec.)
parts of hair from inside out
cortex -->medulla --> cuticle --> internal root sheath --> external root sheath --> glassy membrane
cells of respiratory mucosa
- ciliated columnar
- mucous goblet
- brush cells
- basal (short) cells
- small granule cells