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25 Cards in this Set

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Staining terms
-BASOPHILIC-Blue, neg, binds basic dyes, (nuc-DNA, RER-RNA)

-ACIDOPHILIC-Red, pos, dinds acidic dyes, (prot)

-METACHROMATIC-redish purple, polymerization of dye molec.

-PAS-POS-(goblet, secretions)
connective tissue
Loose
Dense(regular, irreg.)
Cartilage
bone
blood
conn tissue fxn's
exchange of metabolites and waste products
mechanical support
ion balance
storage of energy reserves
repair after injury
shock absorption
insulation
source of heat
defense against pathogens
Loose conn tissue areolar
-regions of mobility and support (b/w muscles and nerves, unerneath epithelium-lamina propia)
-more cells than fibers in ECM
-lots of vasc.
-5 Resident cells-(fibroblasts, fat, plasma, mast, macs
Fibroblasts
-lamina propia (dark blue)
-make ECM materials (pre-collagen(19 types), proelastin, proteoglycans)
-active(wound and youth)/quiesscent
collagen synthesis
-Vit. C important (lack=scurvy)
-makes triple helix
tropocollagen
-tripple helix
1)spontaneously assembles fibrils
2)fibers
3)bundles of collagen fibers = collagen type 1
proelastin
-proelast-->elastin
-rare AA's cross-link elastin
(desmosine, isodesmosine)
ground substance
-GAG's + core prot = proteoglycan (neg, attract water=viscous)
-multiadhesive glycoprots-let cells adhere to ECM, signaling mechanism
Unilocular Fat
-white
-thin cytoplasm
-lots of blood vessles-carry fat(VLDL)
FXN's
-adipose (store E)
-insulate
-prop organs
-cushion
Multilocular Fat
-(brown)
-newborns, hibernating anim.
-close to blood-make heat, give to blood (Thermogen-let H back in mito)
-acidophillic
Plasma cell
-in lamina propia-just under ground substance
-Basophilic
-from B cells, make Ig
Mast Cell
-close blood
-granuals=neg
-dark blue
-IgE act. -->histamines
-Heparin, ECF, NCF-shut down
Macrophages
-bone marrow->monocyte->macs
-irreg border, V or U shape nuc
mac activation
1)coating
2)opsonization
3)recognition/binding
4)ingestion
5)fusion w/ lysosome
6)killing
7)killing and digestion
dense regular CT
-type 1 collagen in parallel->strong
-dark lines=nuc of fibroblasts
-Eg in cornea
Dense irregular CT
-fibers in circular fassion->strength
-(around bladder basal l.)
cartilage FXN's
structural support
shock absorption
reduce friction in joints
template for bone formation (endochondral ossification)
Cartilage
-metachromatic(dk blue)
-AVASCULAR (important)
-gel-like matrix
-2 layers (cartilage, perichondrium)
-chondroblasts(in cart)-make proteoglycans and type 2 collagen
-Perichondrial fibroblast (differentiate from chondroblasts)-form chondrocytes
chondrocytes
-in lacuna
-territorial matrix-immediately around chondrocytes(dark rim)
-interterritorial matrix-b/w lacunae
cart growth
-appositional growth-growing out at perichondrial border

-interstitial growth-growing from center(kids only)
aggrecan
-hyaluronic acid + core prot + type 2 coll. + chondroitin sulfate
-not compressible-cussion of cart
bone surf. cart
no perichondrium-can't repair itself easily ->osteoarthritis
elastic cart
-has perichondrium
-fibers surrounding lacunae
fibrocart
-only cart w/ type 1 coll.
-how injured hyaline cart is repaired
-in IV disk
-b/w bone and tendon