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25 Cards in this Set
- Front
- Back
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Staining terms
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-BASOPHILIC-Blue, neg, binds basic dyes, (nuc-DNA, RER-RNA)
-ACIDOPHILIC-Red, pos, dinds acidic dyes, (prot) -METACHROMATIC-redish purple, polymerization of dye molec. -PAS-POS-(goblet, secretions) |
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connective tissue
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Loose
Dense(regular, irreg.) Cartilage bone blood |
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conn tissue fxn's
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exchange of metabolites and waste products
mechanical support ion balance storage of energy reserves repair after injury shock absorption insulation source of heat defense against pathogens |
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Loose conn tissue areolar
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-regions of mobility and support (b/w muscles and nerves, unerneath epithelium-lamina propia)
-more cells than fibers in ECM -lots of vasc. -5 Resident cells-(fibroblasts, fat, plasma, mast, macs |
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Fibroblasts
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-lamina propia (dark blue)
-make ECM materials (pre-collagen(19 types), proelastin, proteoglycans) -active(wound and youth)/quiesscent |
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collagen synthesis
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-Vit. C important (lack=scurvy)
-makes triple helix |
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tropocollagen
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-tripple helix
1)spontaneously assembles fibrils 2)fibers 3)bundles of collagen fibers = collagen type 1 |
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proelastin
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-proelast-->elastin
-rare AA's cross-link elastin (desmosine, isodesmosine) |
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ground substance
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-GAG's + core prot = proteoglycan (neg, attract water=viscous)
-multiadhesive glycoprots-let cells adhere to ECM, signaling mechanism |
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Unilocular Fat
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-white
-thin cytoplasm -lots of blood vessles-carry fat(VLDL) FXN's -adipose (store E) -insulate -prop organs -cushion |
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Multilocular Fat
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-(brown)
-newborns, hibernating anim. -close to blood-make heat, give to blood (Thermogen-let H back in mito) -acidophillic |
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Plasma cell
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-in lamina propia-just under ground substance
-Basophilic -from B cells, make Ig |
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Mast Cell
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-close blood
-granuals=neg -dark blue -IgE act. -->histamines -Heparin, ECF, NCF-shut down |
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Macrophages
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-bone marrow->monocyte->macs
-irreg border, V or U shape nuc |
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mac activation
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1)coating
2)opsonization 3)recognition/binding 4)ingestion 5)fusion w/ lysosome 6)killing 7)killing and digestion |
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dense regular CT
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-type 1 collagen in parallel->strong
-dark lines=nuc of fibroblasts -Eg in cornea |
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Dense irregular CT
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-fibers in circular fassion->strength
-(around bladder basal l.) |
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cartilage FXN's
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structural support
shock absorption reduce friction in joints template for bone formation (endochondral ossification) |
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Cartilage
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-metachromatic(dk blue)
-AVASCULAR (important) -gel-like matrix -2 layers (cartilage, perichondrium) -chondroblasts(in cart)-make proteoglycans and type 2 collagen -Perichondrial fibroblast (differentiate from chondroblasts)-form chondrocytes |
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chondrocytes
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-in lacuna
-territorial matrix-immediately around chondrocytes(dark rim) -interterritorial matrix-b/w lacunae |
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cart growth
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-appositional growth-growing out at perichondrial border
-interstitial growth-growing from center(kids only) |
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aggrecan
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-hyaluronic acid + core prot + type 2 coll. + chondroitin sulfate
-not compressible-cussion of cart |
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bone surf. cart
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no perichondrium-can't repair itself easily ->osteoarthritis
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elastic cart
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-has perichondrium
-fibers surrounding lacunae |
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fibrocart
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-only cart w/ type 1 coll.
-how injured hyaline cart is repaired -in IV disk -b/w bone and tendon |
