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15 Cards in this Set
- Front
- Back
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Phagocytic and first cells to enter infected tissue
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Neutrophils
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Monocytes when leave blood, enter tissues, activated to become large phagocytic cells
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Macrophages
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Exceptionally potent activators of immune response, resident populations in many tissues/organs
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Dendritic cells
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Activation of these drives inflammation via IL1 and TNF production from phagocytes
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Toll like receptors
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Coating of bacteria with antibody or proteins that tag it for internalisation
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Opsonisation
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A complex series of serum proteins that act in a cascade to help immune system
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Complement
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Complement activation triggered by formation of antibody-antigen complex
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Classical pathway
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Where a component of complement binds to pathogen surface thus marking it for destruction, no prior recognition required- innate recognition
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Alternative pathway
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The end result of both the classical pathway and alternative pathway
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C3 convertase
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Acts as an opsin, contains a highly reactive thioester
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C3b
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Small soluble fragment of C3, leads to increased vascular permeability
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C3a
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A multiprotein complex of C9 together with C5b678 which assembles on surface of bacterium and forms a pore, cell death occurs thru loss of cell integrity
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Membrane attack complex (MAC)
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A molecule (peptide/protein/lipid/DNA) derived from pathogen that when seen by cells of the immune response activates it
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Antigen
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Infection of any cell, upregulated during infection, capable to be expressed on all cells, presented to cytotoxic T-cell
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MHC class 1
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Extracellular bacteria/opsonised bacteria/ viruses phagocytosed, only on antigen presenting cells, phagocytes, APC's activated upregulates this; presented to helper T cells
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Class II MHC
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