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17 Cards in this Set
- Front
- Back
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what is the hippocampus derived from?
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-the medial pallium
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what are the 3 layers of the dentate gyrus?
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-molecular
-granule cell (principal neurons) -hilum |
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what makes up the hippo proper?
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-the CA1 CA2 and CA3 pyramidal cell regions
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what is the major cortical input to the dentate gyrus/hippo?
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-entorhinal ctx
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compare CA3 and CA1 burst characteristics?
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-CA3 are higher frequency and have more sustained firing
-CA1 show accomodation |
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what are the 4 characteristics of LTPs?
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-LTP is induced rapidly but can last hours to days
-LTP can by summation of separate pathways -LTP can be induced associatively (summation of converging inputs) -LTP is input specific |
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what happens when glutamate binds to AMPA receptors?
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-Na enters to depolarize the membrane
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what causes the Mg2+ to remove its block of the NMDA receptor?
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-strong post synaptic depolarization
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what happens when NMDA receptors are activated?
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-Ca2+ enters the dendrite
-AMPA channels get phosphorylated -inc glutamate sensitivity of the cell as "silent" channels open |
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what do late phases of LTP require?
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-protein synthesis (new synapse formation)
-changes in dendrite structure |
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what can NMDA antagonists cause?
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-amnesia
-spatial memory block |
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what is hippocampus essential for?
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-forming declarative memory (explicit/concious)
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what does a bilateral loss of hippocampi result in?
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-failure to convert short term memory into long term
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what two things must happen for a seizure to occur?
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-hyperexcitability
-hypersynchrony |
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hyperexcitability
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-tendency of a neuron to discharge repetitively in response to a stimulus that would normally only elicit one discharge
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hypersynchrony
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-tendency of a large population of neurons to discharge together independently from other neuron populations
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kainic acid
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-an excitotoxin that acts at a class of glutamate receptors
-lets too much Ca2+ into the cell resulting in cell death |
