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17 Cards in this Set

  • Front
  • Back
what is the hippocampus derived from?
-the medial pallium
what are the 3 layers of the dentate gyrus?
-molecular
-granule cell (principal neurons)
-hilum
what makes up the hippo proper?
-the CA1 CA2 and CA3 pyramidal cell regions
what is the major cortical input to the dentate gyrus/hippo?
-entorhinal ctx
compare CA3 and CA1 burst characteristics?
-CA3 are higher frequency and have more sustained firing
-CA1 show accomodation
what are the 4 characteristics of LTPs?
-LTP is induced rapidly but can last hours to days
-LTP can by summation of separate pathways
-LTP can be induced associatively (summation of converging inputs)
-LTP is input specific
what happens when glutamate binds to AMPA receptors?
-Na enters to depolarize the membrane
what causes the Mg2+ to remove its block of the NMDA receptor?
-strong post synaptic depolarization
what happens when NMDA receptors are activated?
-Ca2+ enters the dendrite
-AMPA channels get phosphorylated
-inc glutamate sensitivity of the cell as "silent" channels open
what do late phases of LTP require?
-protein synthesis (new synapse formation)
-changes in dendrite structure
what can NMDA antagonists cause?
-amnesia
-spatial memory block
what is hippocampus essential for?
-forming declarative memory (explicit/concious)
what does a bilateral loss of hippocampi result in?
-failure to convert short term memory into long term
what two things must happen for a seizure to occur?
-hyperexcitability
-hypersynchrony
hyperexcitability
-tendency of a neuron to discharge repetitively in response to a stimulus that would normally only elicit one discharge
hypersynchrony
-tendency of a large population of neurons to discharge together independently from other neuron populations
kainic acid
-an excitotoxin that acts at a class of glutamate receptors
-lets too much Ca2+ into the cell resulting in cell death