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8 Cards in this Set

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FOSCARNET:
1. Interacts directly with herpes virus DNA polymerase
Resistance: point mutations in the viral DNA polymerase.
Where is foscarnet sequestred:
- In the bones and gradual release (10-20%)
- Plasma Cl is decreased prop. w/ CrCl.
- Excreted unchanged in the urine.
A.E. OF foscarnet:
1. Nephrotoxicity
2. Electrolyte disturbances: hypocalcemia, mag, kal, phosphatemia or hyperphosphatemia.
3. CNS: (seizures, ha, tremor, irritability, hallucinations)
Ganciclovir:
- inhibits viral DNA synthesis.
- mono-phosphorylated by virus.
- cessation of chain elongation.

Resistance: reduced intracellular ganciclovir phosphorylation due to mutations in the viral phosphotransferase.
a.e. of ganciclovir
-MYLEOSUPPRESSION: neutropenia or thrombocytopenia.
Cidofovir:
- Cytidine nucleotide analog
- phosphorylated by CELLULAR KINASE.

- metabolite: has a prolonged half-life and serve as intracellular reservior.
CIDOfovir adverse effects:
nephrotoxicity
- probenecid and hydration reduce the risk of nephrot
- adm. with nephrotoxic drugs should be avoided.
Cleared by cidofovir:
- cleared by glomerular filtration and tubular secretion.
- 90% excreted in the urine.