Heparin

Front 1

Heparin
class/ MOA

Back 1

Class
Anticoagulant.
Mechanism of Action
Prevents conversion of fibrinogen to fibrin and affect clotting factors: IX, XI, XII, plasmin.
Does not lyse existing clots.

Front 2

Heparin
Indications

Back 2

Indications
Prophylaxis and treatment of : venous thrombosis, pulmonary embolus, coronary
occlusion, disseminated intravascular coagulation (DIC), post-operative thrombosis.
To maintain patency of IV injection devices and indwelling catheters.

Front 3

Heparin
Contraindications

Back 3

Contraindication
Hypersensitivity.
Patients on antiplatelet drugs (relative contraindication)

Front 4

Heparin
Adverse reactions

Back 4

Adverse Reactions
Hemorrhage, thrombocytopenia, allergic reactions (chills, fever, back pain).

Front 5

Heparin
Drug Interactions

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Drug Interactions
Salicylates, some antibiotics and quinidine may increase risk of bleeding.

Front 6

Heparin
how supplied

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How Supplied
Heparin lock flush solutions in 10 and 100-unit / ml ampules and prefilled syringes.
1,000 - 40,000 units / ml ampules.

Front 7

Heparin
dose and administration

Back 7

Dosage and Administration
Adult: Loading dose: 80 units / kg IV; maintenance dose: 18 units / kg / hour IV.
Pediatric: Loading dose: 50 u / kg IV; maintenance dose: 7.5 units / kg / hour IV.

Front 8

Heparin
DOA

Back 8

Duration of Action
Onset: Immediate.
Peak Effect: Variable.
Duration: 4 hours after continuous infusion discontinued

Front 9

Heparin
Specials

Back 9

Special Considerations
May be neutralized with protamine sulfate at 1 mg protamine / 100 u Heparin: give
slowly IV over 1-3 minutes.