Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
What is the first serological marker detected in Hep A?
|
fecal hepatitis A virus - HAV
|
|
|
When is Fecal HAV detected?
|
during the incubation phase, 15-45 days.
|
|
|
When does the acute disease of Hep A set in?
|
2-12 weeks
|
|
|
What Hep A markers show up during the acute disease stage?
|
IgM anti-HAV first, then IgG.
|
|
|
How would you know was in Convalescence and recovery?
|
If IgG Anti-HAV was high but IgM was low or not detectable.
|
|
|
what is the structure of HAV again?
|
Icosahedral capsid with ssRNA.
|
|
|
What is the structure of Hepatitis C virus??
|
envelped ssRNA.
|
|
|
what is theearliest marker in hep C other than serum transaminases?
|
HCV-RNA detected.
|
|
|
When is HCV RNA first detectable, and then peak?
|
First is in incubation period.
Peak is during 1-3 wk period of acute disease. |
|
|
How would you know a Hepatitis C case was going to resolve?
|
Would see IgM and IgG Ant-HCV rise in the mid-late symptom phase.
|
|
|
What are the signs of chronic hepatitis C?
|
Symptoms reappear and disappear.
No anti-HCV ever appears! HCV-RNA is detectable for months to years, not just first 3 wks. |
|
|
What 2 ways does Hep D infect individuals?
|
1. Coinfection w/ Hep B
2. Superinfection |
|
|
What is the difference between coinfection and superinfection?
|
Co = Hep D and B infect at the same time.
Super = Hep D infects a person that already has Hep B |
|
|
Which is worse, co or super?
Why? |
Super. B/c 80% of people with it progress to cirrhosis, where 90% of coinfections recover.
|
|
|
How can you differentiate serologically a hep D coinfection from super?
|
Hep B markers: follow relatively normal course.
Hep D markers: HDV RNA is only present for a while, where it REMAINS in a superinfection. Also, total Anti-HDV drops way off in co-infection, but stays HIGH in super. |
