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15 Cards in this Set
- Front
- Back
What is the first serological marker detected in Hep A?
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fecal hepatitis A virus - HAV
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When is Fecal HAV detected?
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during the incubation phase, 15-45 days.
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When does the acute disease of Hep A set in?
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2-12 weeks
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What Hep A markers show up during the acute disease stage?
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IgM anti-HAV first, then IgG.
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How would you know was in Convalescence and recovery?
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If IgG Anti-HAV was high but IgM was low or not detectable.
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what is the structure of HAV again?
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Icosahedral capsid with ssRNA.
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What is the structure of Hepatitis C virus??
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envelped ssRNA.
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what is theearliest marker in hep C other than serum transaminases?
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HCV-RNA detected.
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When is HCV RNA first detectable, and then peak?
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First is in incubation period.
Peak is during 1-3 wk period of acute disease. |
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How would you know a Hepatitis C case was going to resolve?
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Would see IgM and IgG Ant-HCV rise in the mid-late symptom phase.
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What are the signs of chronic hepatitis C?
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Symptoms reappear and disappear.
No anti-HCV ever appears! HCV-RNA is detectable for months to years, not just first 3 wks. |
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What 2 ways does Hep D infect individuals?
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1. Coinfection w/ Hep B
2. Superinfection |
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What is the difference between coinfection and superinfection?
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Co = Hep D and B infect at the same time.
Super = Hep D infects a person that already has Hep B |
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Which is worse, co or super?
Why? |
Super. B/c 80% of people with it progress to cirrhosis, where 90% of coinfections recover.
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How can you differentiate serologically a hep D coinfection from super?
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Hep B markers: follow relatively normal course.
Hep D markers: HDV RNA is only present for a while, where it REMAINS in a superinfection. Also, total Anti-HDV drops way off in co-infection, but stays HIGH in super. |