Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
36 Cards in this Set
- Front
- Back
|
what are three steps of platelets
|
adhesion, activation, aggregation
|
|
|
primary hemostasis
|
platelet plug
|
|
|
secondary hemostasis
|
fibrin clot
|
|
|
adhesion membrane receptor
|
glycoprotein Ib/IX;
on platelet.... binds to vWF |
|
|
how are platelets activated
|
secrete alpha granules...... activates gp IIa/IIIb receptor .... phospholipid reorganization..... shape change from rounded to flat for more SA ..... contraction
|
|
|
what is the common pathway
|
x -> Xa
|
|
|
what starts the intrinsic pathway
|
Kal and factor XII
|
|
|
what does thrombin do
|
fibrinogen to fibrin
|
|
|
what is an example of SERPIN
|
antithrombin .... in presence of heparin ..... can bind with thrombin and prevent it from activating fibrin
|
|
|
Protein C
|
with protein S it inactivates cofactors
|
|
|
what starts the extrinsic pathway
|
factor VII
|
|
|
what does plasmin do
|
part of fibrin feedback pathway
plasminogen will bind with tPA and form plasmin ...... break up fibrin clot |
|
|
Prothrombin Time PT
|
measures extrinsic pathway
often a measure of oral anti coagulant |
|
|
Partial Thromboblastin Time
|
measure of intrinsic pathway
|
|
|
normal platelet count
|
150,000- 400,000
|
|
|
mixing study
|
mixes patient plasma with normal plasma
|
|
|
mixing study corrects
|
deficiency
|
|
|
mixing study doesn't correct
|
inhibitor.... factor specific or lupus anticoagulant type
|
|
|
primary hemostasis disorders
|
mucocutaneous bleeding
prolonged bleeding time.... low platelet count |
|
|
secondary hemostasis
|
soft tissue bleeding
elevated PT, PTT, and TT |
|
|
regulatory disorders of hemostatsis
|
soft tissue bleeding
normal lab tests |
|
|
what is dominant clinical manifastation of vW syndrom
|
mucocutaneous bleeding
|
|
|
vW syndrome
|
autosomal dominant
BT/PFA-100 is increased |
|
|
hemophelia A
|
sex linked
soft tissue bleeding usually start in early childhood |
|
|
classifications of hemophelia A
|
<1% VIII
1-5% >5% |
|
|
symptomes of hemophilia A
|
intercranial bleeding
intermuscular hemotoma bleeding into other tissues |
|
|
hemophelia B
|
sex linked
factor IX |
|
|
when does spontaneous bleeding happen
|
platelet count less than 20,000
|
|
|
acute ITP
|
viral prodrom common
sudden onset severe frequent remission |
|
|
chronic
|
adult
female gradual onset moderate infrequent remission |
|
|
what happens in ITP
|
autoantibodies are directed at platelet membrane
increased IgG bound to platelet surface leads to increased sequestering |
|
|
what are common targets of ITP
|
glycoprotein IIa/IIIb and Ib/IX
|
|
|
Thrombotic Thrombocytopenic Purpura
TTP |
intravascular platelet activation .....forms platelet rich micro thrombi throughout circulation
|
|
|
DIC elevates
|
thrombin and plasmin
|
|
|
what are two end products of DIC
|
microvascular thrombosis/ hemmorhage
|
|
|
heparin therepy can treat DIC
|
FALSE
|
