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15 Cards in this Set

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  • Back
Fragmented RBC's caused by mechanical injury in this disease are seen in blood smears as burr cells, helmet cells, and triangular cells
Micro-angiopathic hemolytic anemia
Only acqured membrane defect disorder
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Deficiency of cell membrane proteins (especially DAF), which inhibit complement activity
Paroxysmal Nocturnal Hemoglobinuria (PNH)
This idopathic disease, associtaed with Fanconi anemia, results from the damage of pleuripotent stem cells
Aplastic anemia
This disease is normocytic, normochromic, with no reticulocytes in the peripheral blood smear. There is hypoplasia of the spleen and kidneys
Aplastic anemia
This disease is diagnosed when there is pancytopenis, hypocellular bone marrow, and the replacement of hematopoietic cells in the marrow with adipose tissue
Aplastic anemia
Type of anemia affecting the precursors to red blood cells but not to white blood cells.

May be due to thyroma, viral infections, or drugs
Pure red cell aplasia
-Extensive bone marrow replacement by tumors (especially carcinoma) and other lesions

-Red and white precursors are found in peripheral blood

-Anemia and thrombocytopenia; hemorrage and bleeding
Myelophthisic anemaia
-Myeloproliferative disease

-Abnormal clone of primitive cells - gross overproduction of RBCs

-Increase blood volume/blood viscosity

-Platelet dysfunction/bleeding
Primary Polycythemia
(Polycythemia rubra vera)
-Increased Hb, RBC count, PCV (packed cell volume), WBC count, platelets

-Bone marrow: hyperplastic, abnormal platelet precursors
Primary polycthemia
(polycythemia rubra vera)
-Age 6-8
-Dusky red complexion, cyanosis, splenomegaly
-Thrombosis, hemorrhage
-Headache, visual defects, weakness, GI bleeds
-Myofibrosis (20%), leukemia (10%)
-Median survival 10-20 years, chronic disease
Primary polycythemia
(polycythemia rubra vera)
Can be due to hypoxia (high altitudes, heart disease, pulmonary disease)
or diseases which stimulate erythropoietin (carcinoma of the kidney, polycystic kidney disease)
Secondary Polycythemia
Which has reticulocytes in the peripheral blood and which does not?

-Aplastic anemia
Aplastic anemia - no reticulocytes in periphery

Polycythemia - Reticulocytes (and normoblasts) in peripheral blood
Which, aplastic anemia and polycythemia, has splenomegaly and which does not?
Aplastic anemia - no splenomegaly

Polycythemia - Splenomegaly
Bite cells seen in smear

RBCs eaten by macrophages in spleen

Hemolysis of RBCs triggered by typhoid, viral pneumonia
G6PD deficiency