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15 Cards in this Set
- Front
- Back
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Fragmented RBC's caused by mechanical injury in this disease are seen in blood smears as burr cells, helmet cells, and triangular cells
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Micro-angiopathic hemolytic anemia
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Only acqured membrane defect disorder
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Paroxysmal Nocturnal Hemoglobinuria (PNH)
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Deficiency of cell membrane proteins (especially DAF), which inhibit complement activity
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Paroxysmal Nocturnal Hemoglobinuria (PNH)
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This idopathic disease, associtaed with Fanconi anemia, results from the damage of pleuripotent stem cells
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Aplastic anemia
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This disease is normocytic, normochromic, with no reticulocytes in the peripheral blood smear. There is hypoplasia of the spleen and kidneys
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Aplastic anemia
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This disease is diagnosed when there is pancytopenis, hypocellular bone marrow, and the replacement of hematopoietic cells in the marrow with adipose tissue
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Aplastic anemia
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Type of anemia affecting the precursors to red blood cells but not to white blood cells.
May be due to thyroma, viral infections, or drugs |
Pure red cell aplasia
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-Extensive bone marrow replacement by tumors (especially carcinoma) and other lesions
-Red and white precursors are found in peripheral blood -Anemia and thrombocytopenia; hemorrage and bleeding |
Myelophthisic anemaia
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-Myeloproliferative disease
-Abnormal clone of primitive cells - gross overproduction of RBCs -Increase blood volume/blood viscosity -Platelet dysfunction/bleeding |
Primary Polycythemia
(Polycythemia rubra vera) |
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-Increased Hb, RBC count, PCV (packed cell volume), WBC count, platelets
-Bone marrow: hyperplastic, abnormal platelet precursors |
Primary polycthemia
(polycythemia rubra vera) |
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-Age 6-8
-Dusky red complexion, cyanosis, splenomegaly -Thrombosis, hemorrhage -Headache, visual defects, weakness, GI bleeds -Myofibrosis (20%), leukemia (10%) -Median survival 10-20 years, chronic disease |
Primary polycythemia
(polycythemia rubra vera) |
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Can be due to hypoxia (high altitudes, heart disease, pulmonary disease)
or diseases which stimulate erythropoietin (carcinoma of the kidney, polycystic kidney disease) |
Secondary Polycythemia
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Which has reticulocytes in the peripheral blood and which does not?
-Aplastic anemia -Polycythemia |
Aplastic anemia - no reticulocytes in periphery
Polycythemia - Reticulocytes (and normoblasts) in peripheral blood |
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Which, aplastic anemia and polycythemia, has splenomegaly and which does not?
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Aplastic anemia - no splenomegaly
Polycythemia - Splenomegaly |
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Bite cells seen in smear
RBCs eaten by macrophages in spleen Hemolysis of RBCs triggered by typhoid, viral pneumonia |
G6PD deficiency
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