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9 Cards in this Set
- Front
- Back
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What causes sickling?
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because Hb C has same gel electro pattern as HbA2 (and HbE)
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What causes sickling?
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deoxygenation causes polymerization of HbS
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What factors are protective for leg ulcers in sickle cell dz?
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alpha deletion, increased Hb, increased HbF
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What are risk factors for leg uclers in sickle cell dz?
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male sex, age
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Which is worse…HbH or HbBarts?
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Hb Barts causes intrauterine death
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How do HbH and HbBarts hurt you?
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HbH (gets oxidized and forms inclusions that lead to hemolytic anemia) HbBarts (wont let go of oxygen)
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Neurologic complications in SCD?
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cerebral infarct (kids) cerebral hemorrhage (adults)
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Tx for cerebral infarct in a kid w/SCD?
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exchange or hypertransfusion to maintain HbS<%30
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Why seizures in SCD?
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focus due to infarct; meperidine tx for pain; idiopathic
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