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23 Cards in this Set

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What steps does hematopoiesis consist of?
1. Cellular Proliferation
2. Cellular Differentiation
3. Functional Maturation
4. Death (whether premature or normal)
Where does hematopoises occur in adults?
- bone marrow
- extramedullary hematopoisis (anywhere not in the bone marrow)
Where does hematopoises occur in the fetus?
- aorto-gonadal-mesonephros
- yolk sac
- liver
- slpeen
- lymph nodes
Why would pts. with myeloproliferative disorders have hepatosplenomegally?
- these organs (liver and spleen) regain the fetal function of hematopoiesis --> extramedullary hematopoiesis is occuring
Which bones in adults are involved in hematopoiesis?
- mainly the sternum, ribs, and vertebrae
- long bones loses the abilitly in your 20s
Which bones inthe fetus are involved in hematopoiesis?
- all of them --> why you can do a tibial bone marrow aspiration in peds onc. but not adults
Stem Cell properties?
- ability to differentiate into all hematopoietic lineages
- ability to maintain hematopoiesis over persons lifetime becuase the are self-renewing
Embryonic stem cell
pluripotent
Adult stem cell
- more restricted differentiation
- multipotent adult progenitor cell
Bone marrow stem cell
- hematopoited stem cell
- bone marrow stromal cell
- multipotent stem cells
What does granulopoiesis give rise to?
- neutrophils (PMNs)
- eosinophils
- basophils
Stages of Granulopoiesis
1. Myeloblast
2. Promyelocyte
3. Myelocyte
4. Metamyelocyte
5. Band Cell
6. Segmented Neutrophil
When during the stages of granulopoiesis does the cell acquire primary granules?
Promylocyte
What is the last stage during granulopoiesis where division can occur? (ie. last stage for proliferation)
Myelocyte
When during the stages of granulopoiesis does the cell acquire specific granules?
Metamyelocyte
When during the stages of granulopoiesis does the nucleus start to indent?
Metamyelocyte
When during the stages of granulopoiesis does the nucleus become indented more than halfway?
Band cell
When during the stages of granulopoiesis does the cell become a mature neutrophil?
- when there are lobes and segmentation
Types of WBCs
1. Neutrophils
2. Eosinophils
3. Basophils
4. Monocytes
5. Lymphocytes (B and T)
Types of Granulocytes
1. Neutrophils
2. Eosinophils
3. Basophils
Eosinophils
- bilobed
- allergy cells
- parasites
- ROS
Basophils
- mast cell when in tissues
- purple granules
- histamine -- vasodilator
- heparin -- blood thinner
How long does granulopoiesis take?
~14 days