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23 Cards in this Set
- Front
- Back
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What steps does hematopoiesis consist of?
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1. Cellular Proliferation
2. Cellular Differentiation 3. Functional Maturation 4. Death (whether premature or normal) |
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Where does hematopoises occur in adults?
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- bone marrow
- extramedullary hematopoisis (anywhere not in the bone marrow) |
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Where does hematopoises occur in the fetus?
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- aorto-gonadal-mesonephros
- yolk sac - liver - slpeen - lymph nodes |
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Why would pts. with myeloproliferative disorders have hepatosplenomegally?
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- these organs (liver and spleen) regain the fetal function of hematopoiesis --> extramedullary hematopoiesis is occuring
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Which bones in adults are involved in hematopoiesis?
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- mainly the sternum, ribs, and vertebrae
- long bones loses the abilitly in your 20s |
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Which bones inthe fetus are involved in hematopoiesis?
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- all of them --> why you can do a tibial bone marrow aspiration in peds onc. but not adults
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Stem Cell properties?
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- ability to differentiate into all hematopoietic lineages
- ability to maintain hematopoiesis over persons lifetime becuase the are self-renewing |
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Embryonic stem cell
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pluripotent
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Adult stem cell
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- more restricted differentiation
- multipotent adult progenitor cell |
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Bone marrow stem cell
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- hematopoited stem cell
- bone marrow stromal cell - multipotent stem cells |
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What does granulopoiesis give rise to?
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- neutrophils (PMNs)
- eosinophils - basophils |
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Stages of Granulopoiesis
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1. Myeloblast
2. Promyelocyte 3. Myelocyte 4. Metamyelocyte 5. Band Cell 6. Segmented Neutrophil |
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When during the stages of granulopoiesis does the cell acquire primary granules?
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Promylocyte
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What is the last stage during granulopoiesis where division can occur? (ie. last stage for proliferation)
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Myelocyte
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When during the stages of granulopoiesis does the cell acquire specific granules?
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Metamyelocyte
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When during the stages of granulopoiesis does the nucleus start to indent?
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Metamyelocyte
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When during the stages of granulopoiesis does the nucleus become indented more than halfway?
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Band cell
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When during the stages of granulopoiesis does the cell become a mature neutrophil?
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- when there are lobes and segmentation
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Types of WBCs
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1. Neutrophils
2. Eosinophils 3. Basophils 4. Monocytes 5. Lymphocytes (B and T) |
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Types of Granulocytes
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1. Neutrophils
2. Eosinophils 3. Basophils |
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Eosinophils
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- bilobed
- allergy cells - parasites - ROS |
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Basophils
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- mast cell when in tissues
- purple granules - histamine -- vasodilator - heparin -- blood thinner |
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How long does granulopoiesis take?
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~14 days
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