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17 Cards in this Set
- Front
- Back
Heparin
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Activates Antithrombin= ↓IIa & ↓Xa
Immediate Anticoagulation PE, DVT, stroke, MI, acue coronary syndrome Used during pregnancy monitor PTT (intrinsic path) Tox: osteoporosis, bleeding Heparin-induced Thrombocytopenia= autoantibody production destroys platelets and overactivates remaining ones= thrombocytopenic, hypercoag state |
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Rx for Heparin tox?
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Protamine Sulfate
Pos. compound that binds negatively charged heparin |
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Enoxaprin
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Low Molecular Weight Heparin
Acts more on Xa Better bioavailability and longer 1/2 life Admin w/o laboratory monitoring Not easily reversible |
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Argathrombin
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Direct Thrombin Inhibitors
Heparin-induced Thrombocytopenia |
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Lepirudin
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Direct Thrombin Inhibitors
Heparin-induced Thrombocytopenia |
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Bivalirudin
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Direct Thrombin Inhibitors
Heparin-induced Thrombocytopenia |
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Warfarin
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Interferes with γ-carboxylation of Vitamin K dependent factors:
↓2, 7, 9, 10, C, S Chronic anticoagulation Monitor PT/INR Tox: TERATOGENIC, SKIN/TISSUE NECROSIS (in acquired Protein C deficiencies), bleeding, metabolized by P450 |
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Rx for Warfarin tox?
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Vit. K and Fresh Frozen Plasma
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Streptokinase
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Thrombolytic
Aids conversion of plasminogen into plasmin= cleaves thrombin and fibrin clots Early MI, Ishemic Stroke (w/in 3 hrs) CONTRA: active bleed, history of intracranial bleeds, recent surgery, severe hypertension ↑PT, ↑PTT, normal platelet count |
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Urokinase
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Thrombolytic
Aids conversion of plasminogen into plasmin= cleaves thrombin and fibrin clots Early MI, Ishemic Stroke (w/in 3 hrs) CONTRA: active bleed, history of intracranial bleeds, recent surgery, severe hypertension ↑PT, ↑PTT, normal platelet count |
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Alteplase (tPA)
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Thrombolytic
Aids conversion of plasminogen into plasmin= cleaves thrombin and fibrin clots Early MI, Ishemic Stroke (w/in 3 hrs) CONTRA: active bleed, history of intracranial bleeds, recent surgery, severe hypertension ↑PT, ↑PTT, normal platelet count |
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Antistreplase (APSAC)
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Thrombolytic
Aids conversion of plasminogen into plasmin= cleaves thrombin and fibrin clots Early MI, Ishemic Stroke (w/in 3 hrs) CONTRA: active bleed, history of intracranial bleeds, recent surgery, severe hypertension ↑PT, ↑PTT, normal platelet count |
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Rx for thrombolytic tox?
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Aminocaproic Acid
Inhibitor of fibrinolysis |
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Aspirin
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Irreversible COX-1 and COX-2 inhibitor= ↓TXA2= ↑bleeding time
No effect on PT and PTT Antiplatelet drug Tox: gastric ulceration, bleeding, hyperventilation, Reye's syndrome, tinnitus (CN8) |
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Clopidogrel
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Irreversible blocks ADP receptors on platelets= ↓glycoprotein IIb/IIIa expression
Acute coronary syndrome, coronary stenting, ↓incidence or recurrence of thrombotic stroke |
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Ticlopidine
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Irreversible blocks ADP receptors on platelets= ↓glycoprotein IIb/IIIa expression
Acute coronary syndrome, coronary stenting, ↓incidence or recurrence of thrombotic stroke Tox: neutropenia, bone marrow tox |
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Abciximab
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Binds glycoprotein IIb/IIIa on activated platelets= ↓aggregation
Acute coronary syndromes Tox: bleeding, thrombocytopenia |