Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
closed system that allows blood to circulate throughout the body
|
vasculature
|
|
Primary tissue in immediate contact with the blood in the lumen of the vessel is composed of _____________
|
endothelial cells
|
|
physical properties of vasculature
|
-vasocontriction
-vasodilation -vessel permeability |
|
-short lived reflex reaction
-sustained/ maintained by thromboxane A2, serotonin, and endothelian-1 |
vasoconstriction
|
|
counteracts vasoconstriction by causing dialation
|
Prostacyclin (PGI2)
|
|
-inhibits coagulation under normal conditions
-negatively charged surface that repels plts and hemostatic proteins |
role of endothelium
|
|
-Exposure of basement membrane
-basement membrane forms a surface where plts can adhere -ruptured endothelial cells release ADP |
Role of endothelium in coagulation
|
|
-production and secreation of ____ aids in plt adhesion
-__________ activates extrinsic pathway |
vWF; thromboplastin (tissue factor)
|
|
caused by the extravasation of RBCs from the vasculature into the skin(3)
|
-petechiae
-purpura -ecchymoses |
|
pinpoint red lesions <2mm in size
|
petechiae
|
|
blood leakage with 2mm-1cm in size
|
purpura
|
|
>1cm in size
|
ecchymoses
|
|
due to leakage in the integrity of the vessel itself as a result of inflammation
|
palpable purpura
|
|
due to the increase in intrathoracic pressure of the vessel or external physical or trauma to the vessel
|
non-palpable purpura
|
|
Characterized from:
-tight fitting clothes -coughing -vomitting -weight lifting -excessive excercise -neck compression |
non-palpable purpura
|
|
Causes these:
-petechiae due to thrombocytopenia -venous stasis -purpura become yellow brown due to persistent hemosiderin in skin&tissue |
tight-fitting clothes
|
|
-solar damage to skin and decreased collagen affects integrity of blood vessel wall
-seen in aging pts -purpura patches -no skin elasticity |
senile purpura
|
|
-hyper extensibility of joints
-large ecchymoses, bleeding from the gums, excessive post- partum bleeding and GI bleeding -connective tissue of skin, vessels & bones in affected - "rubber men" |
Ehlers- Danlos syndrome
|
|
-follicular keratosis
-petechiae and ecchymoses seen in extremities and mucous membranes -impaired plt aggregation -causes weakness of joints and pain |
Vitamin C deficiency- scurvy
|
|
-symmetrical lesions over legs and buttocks progress to necrotic lesions
-seen mostly in children -affects kidneys, GI tract, and CNS -pt may demonstrate a nuetrophilia or eosinophilia -typically exhibit abdominal pain or joint pain |
Henoch-Schonlein purpura
|
|
-cold precipitated proteins found in plasma
-hemorrhage w/palpable purpura -systemic manifestations -urticaria -leg ulceration -arthritis, renal involvement, nueropathies |
Cyroglobulinemia
|
|
-bleeding from telangiectasia
-vessel wall ability to contract is diminished -most commonly inherited bleeding disorder -lesions:face,lips,tongue,mucous membranes of mouth, nose, ears, conjunctivae, palms, and souls -# of lesions increase with age -bleeding begins during 2nd or 3 semester of life -epistaxis and ailmentary |
Hereditary hemorrhagic telangiectasia
|