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22 Cards in this Set

  • Front
  • Back
closed system that allows blood to circulate throughout the body
vasculature
Primary tissue in immediate contact with the blood in the lumen of the vessel is composed of _____________
endothelial cells
physical properties of vasculature
-vasocontriction
-vasodilation
-vessel permeability
-short lived reflex reaction
-sustained/ maintained by thromboxane A2, serotonin, and endothelian-1
vasoconstriction
counteracts vasoconstriction by causing dialation
Prostacyclin (PGI2)
-inhibits coagulation under normal conditions
-negatively charged surface that repels plts and hemostatic proteins
role of endothelium
-Exposure of basement membrane
-basement membrane forms a surface where plts can adhere
-ruptured endothelial cells release ADP
Role of endothelium in coagulation
-production and secreation of ____ aids in plt adhesion
-__________ activates extrinsic pathway
vWF; thromboplastin (tissue factor)
caused by the extravasation of RBCs from the vasculature into the skin(3)
-petechiae
-purpura
-ecchymoses
pinpoint red lesions <2mm in size
petechiae
blood leakage with 2mm-1cm in size
purpura
>1cm in size
ecchymoses
due to leakage in the integrity of the vessel itself as a result of inflammation
palpable purpura
due to the increase in intrathoracic pressure of the vessel or external physical or trauma to the vessel
non-palpable purpura
Characterized from:
-tight fitting clothes
-coughing
-vomitting
-weight lifting
-excessive excercise
-neck compression
non-palpable purpura
Causes these:
-petechiae due to thrombocytopenia
-venous stasis
-purpura become yellow brown due to persistent hemosiderin in skin&tissue
tight-fitting clothes
-solar damage to skin and decreased collagen affects integrity of blood vessel wall
-seen in aging pts
-purpura patches
-no skin elasticity
senile purpura
-hyper extensibility of joints
-large ecchymoses, bleeding from the gums, excessive post- partum bleeding and GI bleeding
-connective tissue of skin, vessels & bones in affected
- "rubber men"
Ehlers- Danlos syndrome
-follicular keratosis
-petechiae and ecchymoses seen in extremities and mucous membranes
-impaired plt aggregation
-causes weakness of joints and pain
Vitamin C deficiency- scurvy
-symmetrical lesions over legs and buttocks progress to necrotic lesions
-seen mostly in children
-affects kidneys, GI tract, and CNS
-pt may demonstrate a nuetrophilia or eosinophilia
-typically exhibit abdominal pain or joint pain
Henoch-Schonlein purpura
-cold precipitated proteins found in plasma
-hemorrhage w/palpable purpura
-systemic manifestations
-urticaria
-leg ulceration
-arthritis, renal involvement, nueropathies
Cyroglobulinemia
-bleeding from telangiectasia
-vessel wall ability to contract is diminished
-most commonly inherited bleeding disorder
-lesions:face,lips,tongue,mucous membranes of mouth, nose, ears, conjunctivae, palms, and souls
-# of lesions increase with age
-bleeding begins during 2nd or 3 semester of life
-epistaxis and ailmentary
Hereditary hemorrhagic telangiectasia