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27 Cards in this Set
- Front
- Back
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heparin MOA
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catalyzes the activation of antithrombin III and Xa; short t1/2 (given iv infusion)
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heparin use
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immediate antigcoag for PE, stroke, angina, MI and DVT
used during pregnancy |
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with heparin you follow
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PTT (intrinsic pathway)
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heparin tox
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bleeding, heparin induced TCP
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heparin reversal
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protamine sulfate
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warfarin MOA
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interferes with normal synthesis and gamma carboxylation of vit-K dependent clotting factors II, VII, IX, and X and protein C and S
extrinsic pathway |
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with warfarin you follow
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PT
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use of warfarin
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chronic anticoag; not used in pregnant women
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tox of warfarin
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bleeding, teratogenic, DI
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thrombolytics
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SK, urokinase, tPA, APSAC
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MOA of thrombolytics
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directly or indirectly aid conversion of plasminogen to plasmin (fibrinolytic enzyme) which cleaves thrombin and fibrin clots
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use of thrombolytics
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early MI (ST segement elevation MI), early ischemic stroke
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tox of thrombolytics
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bleeding; CI in pts with active bleeding, hx of IC bleeding, rectal surg, hypertension
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antidote of thrombolytics
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aminocaproic acid
(inhibitor of fibrinolysis) |
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aspirin MOA
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acetlyates and irreversibly inhibits COX to prevent conversion of arachidonic acid to prostaglandins
increase bleeding time no effect on PT, PTT |
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use of aspirin
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antipyretic, analgesia, antiinflamm, antiplatelet drug
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tox of aspirin
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gastric ulceration, bleeding, hypervent, Reye's syndrome, tinnitus
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clopidogrel, ticlopidine MOA
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inhibit platelet aggregation by irreversibly blocking ADP receptors
inhibt fibrinogen binding by preventing glycoprotein IIb/IIIa expresion |
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use of clopidogrel, ticlopidine
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acute coronary syndrome, coronary stenting, decreased incidence to thrombolytic stroke
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tox of ticlopidine
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neutropenia
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abciximab, tifofiban, ebtifibatide
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block IIb/IIIa receptor on activated platelets, preventing aggregation
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use of GP IIb/IIIa inhib
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acute coronary syndromes, percutaneous transluminal coronary angioplasty, nonST segment elevation
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tox of GP IIb/IIIa inhib
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bleeding, TCP
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platelet adhesion
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GP1b, vWf, endothelial damage
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platelet activation
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secretion of ADP, PDGF, serotonin, fibrinogen, lysosomal enzymes, TXA A2 (vasoconstriction, platelet agg), calcium, thrombin (fibrinogen-->fibrin)
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aggregation of platelets
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GP IIb/IIIa
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vWf major functions
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complexes with and stabilizes factor VIII (def- increased PTT)
platelet adhesion to vessel wall and to other platelets (def- increased bleeding time) |
