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27 Cards in this Set

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  • Back
heparin MOA
catalyzes the activation of antithrombin III and Xa; short t1/2 (given iv infusion)
heparin use
immediate antigcoag for PE, stroke, angina, MI and DVT
used during pregnancy
with heparin you follow
PTT (intrinsic pathway)
heparin tox
bleeding, heparin induced TCP
heparin reversal
protamine sulfate
warfarin MOA
interferes with normal synthesis and gamma carboxylation of vit-K dependent clotting factors II, VII, IX, and X and protein C and S
extrinsic pathway
with warfarin you follow
PT
use of warfarin
chronic anticoag; not used in pregnant women
tox of warfarin
bleeding, teratogenic, DI
thrombolytics
SK, urokinase, tPA, APSAC
MOA of thrombolytics
directly or indirectly aid conversion of plasminogen to plasmin (fibrinolytic enzyme) which cleaves thrombin and fibrin clots
use of thrombolytics
early MI (ST segement elevation MI), early ischemic stroke
tox of thrombolytics
bleeding; CI in pts with active bleeding, hx of IC bleeding, rectal surg, hypertension
antidote of thrombolytics
aminocaproic acid
(inhibitor of fibrinolysis)
aspirin MOA
acetlyates and irreversibly inhibits COX to prevent conversion of arachidonic acid to prostaglandins
increase bleeding time
no effect on PT, PTT
use of aspirin
antipyretic, analgesia, antiinflamm, antiplatelet drug
tox of aspirin
gastric ulceration, bleeding, hypervent, Reye's syndrome, tinnitus
clopidogrel, ticlopidine MOA
inhibit platelet aggregation by irreversibly blocking ADP receptors
inhibt fibrinogen binding by preventing glycoprotein IIb/IIIa expresion
use of clopidogrel, ticlopidine
acute coronary syndrome, coronary stenting, decreased incidence to thrombolytic stroke
tox of ticlopidine
neutropenia
abciximab, tifofiban, ebtifibatide
block IIb/IIIa receptor on activated platelets, preventing aggregation
use of GP IIb/IIIa inhib
acute coronary syndromes, percutaneous transluminal coronary angioplasty, nonST segment elevation
tox of GP IIb/IIIa inhib
bleeding, TCP
platelet adhesion
GP1b, vWf, endothelial damage
platelet activation
secretion of ADP, PDGF, serotonin, fibrinogen, lysosomal enzymes, TXA A2 (vasoconstriction, platelet agg), calcium, thrombin (fibrinogen-->fibrin)
aggregation of platelets
GP IIb/IIIa
vWf major functions
complexes with and stabilizes factor VIII (def- increased PTT)
platelet adhesion to vessel wall and to other platelets (def- increased bleeding time)