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8 Cards in this Set

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An erythroblast containing granules of ferritin.
Used in the diagnosis of autoimmune diseases.

It detects antibodies bound to the surface of red blood cells.

The red blood cells (RBCs) are washed (removing the patient's own serum) and then incubated with antihuman globulin (also known as "_______ reagent").

If this produces agglutination of the RBCs, the direct Coombs test is positive.
Direct Coombs Test
Used in prenatal testing of pregnant women, and in testing blood prior to a blood transfusion.

It detects antibodies against RBCs that are present unbound in the patient's serum.

In this case, serum is extracted from the blood, and the serum is incubated with RBCs of known antigenicity.

If agglutination occurs, the indirect Coombs test is positive
Indirect Coombs test
Primary, malignant, too many of all cells but predominantly shown as a red cell disease
Polycythemia vera
Response to a hormone, like erythropoietin, that could be released in response to diesease

Cancer in the kidney causing an increase in erythropoietin release or

Severe pulmonary disease - can't get enough oxygen in the blood - kidneys respond by increasing erythropoietin producion
Secondary Polycythemia
(+) DAT, IAT, low serum haptoglobin, bilirubinemia, hemoglobinuria, bleeding from DIC and renal shutdown
Effects of hemolysis
May not have an increase in cell number, but decrease in amount of plasma

causes hematocrit to increase (from dehydration) or spurious causes (pregnancy)
Relative polycythemia
Primary hemostatic plug does not form with this disorder as compared to clotting disorders w/ missing clotting factors