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15 Cards in this Set
- Front
- Back
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Hematopoiesis
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-occurs in bone marrow of adults
-red bone marrow is hematopoietically active, yellow is inactive |
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Pre-natal
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-Yolk sac, liver and spleen, bone marrow
-continues in live and spleen for few weeks after birth |
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Structure of Bone Marrow
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-artery open into vascular sinuses
Endothelial lining -discontinuous basal lamina -discontinuous layer of advential cells -erythropoietic cells and megakaryocytes are close to sinuses. granulopoietic cells are located in deeper part |
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Hematopoietic stem cells
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-pluripotent set cell gives rise to all cell types
-multipotent stem cell gives rise to more than one cell type -unipotent stem cell gives rise to only one cell type |
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Maturation and delivery of blood cells
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-adventitial cells move away (control release)
-basal lamina depolymerizes -apeture is created through the cytoplasm of endothelial cell -mature cells pass through |
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Erythropoiesis
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-requires 5-7 days to complete
-6-8 fold increase when demand Erythroblastic islands: -central macrophage -1-2 tiers of erythroid cells, out more mature. |
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Erythrocytic Lineage
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CFU-E
Rubriblast Prorubricyte Basophilic rubricyte Metarubricyte Reticulocyte Erythrocyte Basophilic Polychromatic Orthochromatic |
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What happens during development
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-decreased in RNA
-increase Hb -decreased nuclear size -increase heterochromatin -loss of nucleoli -loss of organelles -loss of nucleus |
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Erythrocyte Kinetics and regulation
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erythropoietin
aged rbc's removed from circulation by spleen |
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Granulopoiesis
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GFU-GK
Myeloblast Promyelocyte myelocyte metamyelocyte band cell segs progressive granular appearance of cytoplasm and condensation, indentation and segmentation of nucleus |
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Kinetics and Regulation
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-5-7 days
Three compartments: -Proliferative: myeloblasts, promyelocytes, myelocytes -Maturative: metamyelocytes, band neutrophils -Reserve (storage): mature neutrophils -In blood: circulating pool, marginal pool |
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Monocytopoiesis
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-retain nucleoli while maturing
-enter circulation relatively immature -monocytes differentiate into macrophages |
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Thrombopoiesis
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GFU-MK
Megakaryoblast Megakaryocyte: endomitosis Platelets: fragmentations of megakaryocyte cytoplasm LARGEST marrow cell regulated by thrombopoietin |
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Platelets
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-life 9-12 days
-large amount stored in spleen -aged ones removed by mononuclear phagocytic system (MPS) |
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Bone Marrow in Birds
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Granulopoiesis
-outside sinuses Erythropoiesis and Thrombopoiesis -inside sinuses, immature cells bind to walls -no megakaryocytes -thrombocytes vs. platelets -erythrocytes are elliptical w/ heterochromatic nucleus -heterophils/neutrophils -eosinophils have bead shaped granules -monocytes are the largest lymphocytes |
