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15 Cards in this Set

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Hematopoiesis
-occurs in bone marrow of adults
-red bone marrow is hematopoietically active, yellow is inactive
Pre-natal
-Yolk sac, liver and spleen, bone marrow
-continues in live and spleen for few weeks after birth
Structure of Bone Marrow
-artery open into vascular sinuses
Endothelial lining
-discontinuous basal lamina
-discontinuous layer of advential cells
-erythropoietic cells and megakaryocytes are close to sinuses. granulopoietic cells are located in deeper part
Hematopoietic stem cells
-pluripotent set cell gives rise to all cell types
-multipotent stem cell gives rise to more than one cell type
-unipotent stem cell gives rise to only one cell type
Maturation and delivery of blood cells
-adventitial cells move away (control release)
-basal lamina depolymerizes
-apeture is created through the cytoplasm of endothelial cell
-mature cells pass through
Erythropoiesis
-requires 5-7 days to complete
-6-8 fold increase when demand
Erythroblastic islands:
-central macrophage
-1-2 tiers of erythroid cells, out more mature.
Erythrocytic Lineage
CFU-E
Rubriblast
Prorubricyte
Basophilic rubricyte
Metarubricyte
Reticulocyte
Erythrocyte

Basophilic
Polychromatic
Orthochromatic
What happens during development
-decreased in RNA
-increase Hb
-decreased nuclear size
-increase heterochromatin
-loss of nucleoli
-loss of organelles
-loss of nucleus
Erythrocyte Kinetics and regulation
erythropoietin
aged rbc's removed from circulation by spleen
Granulopoiesis
GFU-GK
Myeloblast
Promyelocyte
myelocyte
metamyelocyte
band cell
segs

progressive granular appearance of cytoplasm and condensation, indentation and segmentation of nucleus
Kinetics and Regulation
-5-7 days
Three compartments:
-Proliferative: myeloblasts, promyelocytes, myelocytes
-Maturative: metamyelocytes, band neutrophils
-Reserve (storage): mature neutrophils
-In blood:
circulating pool, marginal pool
Monocytopoiesis
-retain nucleoli while maturing
-enter circulation relatively immature
-monocytes differentiate into macrophages
Thrombopoiesis
GFU-MK
Megakaryoblast
Megakaryocyte: endomitosis
Platelets: fragmentations of megakaryocyte cytoplasm

LARGEST marrow cell

regulated by thrombopoietin
Platelets
-life 9-12 days
-large amount stored in spleen
-aged ones removed by mononuclear phagocytic system (MPS)
Bone Marrow in Birds
Granulopoiesis
-outside sinuses
Erythropoiesis and Thrombopoiesis
-inside sinuses, immature cells bind to walls
-no megakaryocytes
-thrombocytes vs. platelets
-erythrocytes are elliptical w/ heterochromatic nucleus
-heterophils/neutrophils
-eosinophils have bead shaped granules
-monocytes are the largest lymphocytes