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16 Cards in this Set
- Front
- Back
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What are the CD markers of pluripotent HSCs?
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CD34+
CD38- |
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Where is hematopoiesis initiated at:
1month 3-5months 7+ months ? |
1: yolk sac
3-5: fetal liver and spleen 7+: bone marrow |
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Where is TPO synthesized?
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liver
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EPO production, when is it constitutive vs inducible?
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Constitutive in the liver
Inducible in the kidney |
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At what stage are platelets liberated?
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When in the megakaryocyte it's at the 8 lobe stage in the cytoplasm when it becomes granular and the platelets are liberated
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Do RBCs have an EPO receptor?
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No
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Are neutrophil precursors normally found in blood?
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no, just mature neutrophils
lifespan of neutrophils int he blood is only 10h |
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Monocyte/macrophage blood vs tissue
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Monocyte: circulate blood 20-40h then leave blood to tissue
Macorphage: can survive for months to years |
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hypoxic environment affect on RBCs?
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Drives production (legal blood doping)
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Inflammation affect on B cell production and neutrophil production?
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B cell production = reduced
neutrophil production = increased |
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How are HSCs mobilized from bone marrow?
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G-CSF causes proliferation of neutrophils and release of proteases, proteases degrade proteins that anchor stem cells to the marrow stroma = liberation
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megakaryocytes are where in the body? where are thrombocytes?
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megakaryoctes are in the marrow, thrombocytes = blood
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What secretes G-CSF?
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fibroblasts
macrophages |
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What do reticulocytes contain?
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No DNA in nucleus, RNA in cytoplasm
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At what stage is the defect in development in CML?
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Pluripotent Stem cell
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Thymocytes that interact with ____ bound to self glycolipid expressed by other DP thymocytes become NK cells
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CD1d = NK cells
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