• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/40

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

40 Cards in this Set

  • Front
  • Back
What is Anemia?
reduced number of RBCs which results in decreased oxygen delivery
note: often due to underlying cause
Hgb for moderate anemia:

Severe anemia
7-10g/dl
<7g/dl
This is seen in adaptation of chronic anemias?
increase of 2,3 bisphosphoglycerate
This is seen elevated in hemolytic anemias.
Reticulocyte count
A bone marrow exam reveals the maturation patterns of _____ and _____.
RBCs and WBCs
What is ineffective erythropoiesis?
production of progenitor cells that are defective
megaloblastic, thalassemia, and sideroblastic anemias will have increased?
RBC precurses
What is insufficient erythropoiesis?
is a lack of erythroid precursers in bone marrow
Aplastic anemia is
a loss of erythroid precurser to an autoantibody
This determines whether the anemia is due to a production defect or to increase or early distruction.
Reticulocyte count
Normocytic, normachromic =
MCV =
MCH =
MCHC =
MCV = 80 - 100
MCH = 27 - 32
MCHC = 32 - 36
Microcytic, normochromic =
MVC =
MCHC =
MVC = <80
MCHC = <32
Microcytic, normochromic is caused by conditions that result in reduced _____ synthesis
Hgb
Macrocytic, normachromic =
MCV =
MCHC =
MCV = >100
MCHC =>32
Macrocytic, normachromic is characterized by?
oval macrocytes and teardrop shaped cells
RDW/ anisocytosis =
variation in RBC size
MCV and RDW for thalassimia
MCV = low
RDW = normal
MCVand RDW for iron deficiency
MCV = low
RDW = high
MCV and RDW for vit b12 or folate deficiency
MCV = high
RDW = high
MCV and RDW for anemia hemoglobinopathy
MCV = normal
RDW = high
Iron deficiency anemias result from?
inadiquate stores of iron
Anemia of chronic inflamation results from?
impared mobilization of iron
sideroblastic anemia results from?
RBC defect preventing iron incorporation into heme
Iron is distibuted in these three compartments?
storage-ferritin
transport-transferrin
functional-Hgb, Myoglobin
4 groups prone to iron deficiency anemia
menstrating women
adolecent girls
pregnant and nursing women
growing children
lab diagnosis of iron deficiency anemia?
CBC begins to show microcytosis, hypochromia, decreased Hgb/RBC/Hct
Anemia of
chronic inflamation is when?
iron absorption is decreased during inflamation and becomes unavailable to developing RBCs
Hepcidin
regulates iron levels by reducing the amount of iron absorbed.
lactoferrin
iron binding protein in the granules of neutrophils, has a greater avidity for iron than transferrin
Lab diagnostics for anemia of chronic inflamation
decreased serum iron and TIBC
HGB 9-11 without reticulocytosis
Etiology of sideroblastic anemia
interferes with production ofadequate amounts of heme
iron is abundant in marrow
sideroblastic anemia lab diagnostics
microcytic and hypochromic
iron deposites in normoblasts in the mitochondria
impaired mental developement may be a result of
sideroblastic anemia
(sideroblastic anemia) lead poisoning lab diag.
elevated retic count
basophilic stippling is classic finding
porphorias etiology
impaired production of heme can be aquired or heredity
What is hemochromatosis?
developes as a result of mutations affecting the proteins of iron metabolism
4 organs that can be damaged by iron overload?
skin, liver, pancreas, heart
iron overload is most common in?
men 40-60
iron overload = an amount of transferrin saturation of
>60%
MCV ref range
80-100