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26 Cards in this Set

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What does heparin do?
Heparin facilitates the action of antithrombin III
What does antithrombin III do?
Antithrombin III inactivates thrombin, Factor IXa, and Factor Xa
Reversal of heparin toxicity
Protamine Sulfate reverses heparin overdose
Enoxaparin
Enoxaparin- low molecular weight heparin
Dalteparin
Dalteparin- low molecular weight heparin
Fondaparinux
Fondaparinux- heparin analogue that only inhibits Factor Xa
Coagulation proteins that require Vitamin K to function
Prothrombin, Factor VII, Factor IX, Factor X, Protein C, Protein S all require Vitamin K to function
Warfarin
Warfarin inhibits Vitamin K Epoxide Reductase
Administration of Warfarin
Warfarin is orally active
Contraindication- pregnant women
Lepirudin
Lepirudin is a direct thrombin inhibitor
Dabigatran
Dabigatran is a direct thrombin inhibitor
Advantages and clinical use of Dabigatran
Dabigatran is an orally active thrombin inhibitor that is indicated to prevent thrombi in atrial fibrillation patients.

Advantages: orally active, don't have to monitor blood
Bivalirudin
Bivalirudin- direct thrombin inhibitor
Argatroban
Argatroban- direct thrombin inhibitor
MOA of fibrinolytic drugs
Fibrinolytic drugs facilitate the formation of Plasmin from Plasminogen, which dissolves the fibrin in clots
Clinical indication for fibrinolytic drugs
Fibrinolytic drugs are used to treat arterial thrombi
Streptokinase
Streptokinase- fibrinolytic drug (drives Plasminogen --> Plasmin)
Alteplase
Alteplase- recombinant tPA (fibrinolytic drug that drives Plasminogen --> Plasmin)
Aspirin
Aspirin inhibits cyclooxygenase, which prevents formation of TxA2 (thromboxane)
Clopidogrel
Clopidogrel blocks ADP receptor, thereby inhibiting GPIIa/IIIb expression
Abciximab
Abciximab is a monoclonal antibody that blocks GPIIa/IIIb on platelets
Eptifibatide
Eptifibatide blocks GPIIa/IIIb on platelets
Tirofiban
Tirofiban blocks GPIIa/IIIb on platelets
Cilostazal
Cilostazal blocks phosphodiesterase III thereby preventing platelet aggregation
Drugs to prevent MI
Drugs to prevent MI:
Aspirin, Abciximab, Eptifibatide, Tirofiban, Clopidogrel
Drugs to prevent TIA and stroke
Drugs to prevent TIA and stroke: aspirin, clopidogrel