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10 Cards in this Set
- Front
- Back
What is wrong with the neutrophils seen here?
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Toxic granulations. The azurophilic granules are indicative of immaturity. Patient could have a massive infection or another reason to be putting out immature cells
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What autosomal dominant congenital abnormality has basophilic inclusions that may resemble Dohle bodies? What other findings are characteristic on blood smear?
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May-Hegglin anomaly, but also GIANT platelets. Usually benign, sometimes thrombocytopenia
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What is a neutrophil anomaly associated with mucopolysaccharidoses, and what are the findings on blood smear?
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Alder-Reilly anomaly. Blood smear will show many azurophilic granules in granulocytes, lymphocytes and monocytes.
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What are the two possible causes of the pince-nez appearance of these polys?
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Congenital (innocuous)
or acquired (pseudo Pelger-Huet - myelodysplasia) |
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If this cell was on a peripheral smear of a child with oculocutaneous albinism, what else would you expect on history?
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Frequent infections from Chediak-Higashi syndrome, a defect in fusion/trafficking of vesicles (including melanosomes)
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What type of anemia is seen here?
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Iron deficiency anemia - hypochromatic with increased central pallor and pencil cells
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What type of anemia is seen here?
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Thallassemia - increased central pallor, target cells
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What causes this type of anemia?
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B12 deficiency - multilobulated PMN, irregular shapes
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What can cause the appearance of these cells?
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Thalassemia, Liver disease, severe Iron deficiency, Heme C disease, asplenia
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What causes spherocytosis?
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Hereditary spherocytosis caused by mutations in cytoskeleton proteins
Autoimmune hemolysis |
