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25 Cards in this Set

  • Front
  • Back
What are the caues of DIC?
STOP Making New Thrombi: Sepsis (gram-negative), Traume, Obstetric complications, acute Pancreatitis, Malignancy, Nephrotic syndrome, Transfusion
What lab findings would you expect for DIC? (PT, PTT, D-dimers, platelet count, blood smear)
PT: increased; PTT: increased; fibrin split products: increased; platelet count: decreased; blood smear: helmet-shaped cells and schistocytes
Disease: mucous membrane bleeding, epistaxis, petechiae, purpura, increased bleeding time
Platelet abnormalities
Disease: hemarthroses, easy bruising, increased PT and/or PTT
Coagulation factor defects
List some platelet abnormality disorders
Idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, DIC, aplastic anemia, drugs
List some coagulation factor defect disorders
Hemophilia A, hemophilia B, von Willebrand's disease
What are the prothrombin (PT) factors?
(Extrinsic) Factors II, V, VII, X
What are the partial thromboplastin (PTT) factors?
(Intrinsic) All factors except VII and XIII
Hemorrhagic disorder: platelet count decreased; bleeding time increased; PT normal; PTT normal
Thrombocytopenia
Hemorrhagic disorder: platelet count normal; bleeding time normal; PT normal; PTT increased
Hemophilia A or B
Hemorrhagic disorder: platelet count normal; bleeding time increased; PT normal; PTT increased
von Willebrand's disease
Hemorrhagic disorder: platelet count decreased; bleeding time increased; PT increased; PTT increased
DIC
Hemorrhagic disorder: platelet count normal; bleeding time normal; PT increased; PTT increased
Vitamin K deficiency
Hemorrhagic disorder: platelet count decreased; bleeding time increased; PT normal; PTT normal
Bernard-Soulier disease
Hemorrhagic disorder: platelet count normal; bleeding time increased; PT normal; PTT normal
Glanzman's thrombasthenia
Hemorrhagic disorder: peripheral platelet destruction, increased megakaryocytes, antiplatelet antibodies
Idiopathic thrombocytopenic purpura
Hemorrhagic disorder: increased platelet aggregation, increaed lactate dehydrogenase, neurologic and renal symptoms, fever
Thrombotic thrombocytopenic purpura
Hemorrhagic disorder: schistocytes, increased fibrin split products
DIC
What factor is deficient in hemophilia A?
Factor VIII
What factor is deficient in hemophilia B?
Factor IX
What factor is deficient in von Willebrand's disease and what does that affect?
vWF; defective platelet adhesion and decreased factor VIII survival
What is the etiology of Bernard-Soulier disease?
defective platelet adhesion, decreased GpIb
What is the etiology of Glanzmann's thrombasthenia?
Defect of platelet aggregation, decreased GP IIb-IIIa
At what platelet count level does generalized bleeding occur?
15,000-20,000/mm^3
At what platelet count level does thrombocytopenia occur?
< 100,000/mm^3