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25 Cards in this Set
- Front
- Back
What are the caues of DIC?
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STOP Making New Thrombi: Sepsis (gram-negative), Traume, Obstetric complications, acute Pancreatitis, Malignancy, Nephrotic syndrome, Transfusion
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What lab findings would you expect for DIC? (PT, PTT, D-dimers, platelet count, blood smear)
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PT: increased; PTT: increased; fibrin split products: increased; platelet count: decreased; blood smear: helmet-shaped cells and schistocytes
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Disease: mucous membrane bleeding, epistaxis, petechiae, purpura, increased bleeding time
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Platelet abnormalities
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Disease: hemarthroses, easy bruising, increased PT and/or PTT
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Coagulation factor defects
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List some platelet abnormality disorders
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Idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, DIC, aplastic anemia, drugs
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List some coagulation factor defect disorders
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Hemophilia A, hemophilia B, von Willebrand's disease
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What are the prothrombin (PT) factors?
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(Extrinsic) Factors II, V, VII, X
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What are the partial thromboplastin (PTT) factors?
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(Intrinsic) All factors except VII and XIII
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Hemorrhagic disorder: platelet count decreased; bleeding time increased; PT normal; PTT normal
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Thrombocytopenia
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Hemorrhagic disorder: platelet count normal; bleeding time normal; PT normal; PTT increased
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Hemophilia A or B
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Hemorrhagic disorder: platelet count normal; bleeding time increased; PT normal; PTT increased
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von Willebrand's disease
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Hemorrhagic disorder: platelet count decreased; bleeding time increased; PT increased; PTT increased
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DIC
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Hemorrhagic disorder: platelet count normal; bleeding time normal; PT increased; PTT increased
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Vitamin K deficiency
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Hemorrhagic disorder: platelet count decreased; bleeding time increased; PT normal; PTT normal
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Bernard-Soulier disease
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Hemorrhagic disorder: platelet count normal; bleeding time increased; PT normal; PTT normal
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Glanzman's thrombasthenia
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Hemorrhagic disorder: peripheral platelet destruction, increased megakaryocytes, antiplatelet antibodies
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Idiopathic thrombocytopenic purpura
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Hemorrhagic disorder: increased platelet aggregation, increaed lactate dehydrogenase, neurologic and renal symptoms, fever
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Thrombotic thrombocytopenic purpura
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Hemorrhagic disorder: schistocytes, increased fibrin split products
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DIC
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What factor is deficient in hemophilia A?
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Factor VIII
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What factor is deficient in hemophilia B?
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Factor IX
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What factor is deficient in von Willebrand's disease and what does that affect?
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vWF; defective platelet adhesion and decreased factor VIII survival
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What is the etiology of Bernard-Soulier disease?
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defective platelet adhesion, decreased GpIb
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What is the etiology of Glanzmann's thrombasthenia?
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Defect of platelet aggregation, decreased GP IIb-IIIa
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At what platelet count level does generalized bleeding occur?
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15,000-20,000/mm^3
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At what platelet count level does thrombocytopenia occur?
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< 100,000/mm^3
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