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14 Cards in this Set
- Front
- Back
Lymphomas: Hodgkin's Versus NHL: Which one presents with Reed-Sternberg cells?
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Hodgkin's lymphoma (HL)
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Lymphomas: Hodgkin's Versus NHL: Which one is associated with HIV and immunosuppression?
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Non-Hodgkin Lymphoma (NHL)
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Lymphomas: Hodgkin's Versus NHL: Which one is localized to a single group of nodes, with contagious spread and rare extranodal involvement?
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HL
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Lymphomas: Hodgkin's Versus NHL: Which one has hypergammaglobulinemia?
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Neither. Multiple Myeloma has hypergammaglobulinemia, where the excess B cells are in the resting state.
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B cell small lymphocytic lymphoma (CLL)
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Morphology: predominantly small lymphocytes
Immunology. surface IgM+, CD5+, CD10-, CD 19,20,79a +, CD22+/-, CD 23+ Genetics: trisomy 12 or 13q Clinical: leukemic, adult, indolent course |
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Mycosis Fungoides
and Sezary Syndrome |
Most common CUTANEOUS lymphoma.
small lymphocytes with irregular nuclear outlines Sezary syndrome= circulating lymphoma cells Immunophenotype: CD3, 5, 2, 4(90%) CD8+ and CD4- (10%) CD7- (!) Age: 55-60 Mucosis Fungoides: 10 year survival, 97% due to slow progression Sezary: more aggressive, 5 year survival. |
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Mantle cell lymphoma (MCL)
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Derived from the cells of the Folicular mantle zone of lymphoid folicle.
Medium sized lymphocytes. Immunophenotype: surface Ig+, CD19, 20, 5(!) CD23 - T(11:14) bcl-1 protooncogene, loss of cell cycle control Clinical:60 y.o. Poor response to chemotherapy. Survival 18 month |
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Diffuse large B cell lymphoma
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LARGE CELL SIZE! Most common worldwide.Can develop from low grade lymphoma (folicular). Localized to a group of lymph nodes( bone marrow involvement latter)
Immunophenotype: CD19, 20+ Can develop variety of markers, depending on development stage. Age: 60-70 y.o., also in children, young adults. Clinical: high proliferation rate, but sensitive to chemotherapy. 60-80% remission rate. HIV+ patients have worse prognosis. |
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Follicle Center Lymphoma
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Morphology: Mixture of germinal center blasts and cleaved cells.
Immunology:surface Ig+, CD19, 20,22, 79a+ CD10+/-, DC5-, BCL-2 Genetics:t(14;18) and bcl-2 Clinical: adults, indolent course, median survival of 7-9 years. |
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Mucosa Associated Lymphoid Tissue Lymphoma
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B cell neoplasm: small, medium and large cells, round or cleaved nuclei. Looks like reactive lymphoid tissue. Associated with infections.
No CD5 and CD10 Antibiotics may induce a remission if caused by infection. Referred as marginal zone lymphoma (MZL) |
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Burkitt's Lymphoma
Mature B cell |
"Starry sky"
Medium sized cells, basophilic cytoplasm. High mitotic rate Immunophenotype: surface IgM+, CD5, 23- CD10, 19, 20, 22,79a+ Genetics: t(2:8) (8:14) (8:22) Clinical: children, adults. Aggressive, but curable in children. |
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Peripheral T/NK cell lymphoma
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Mature T+NK cell
Diffuse with lymph node involvement Medium, large sized cells with atypical nuclei. Immunophenotyping: most CD4. Variable loss of pan T cell antigens 15% of lymphomas in US. Clinical: 60 y.o.Aggressive with frequent relapses. 3 years survival rate:40% |
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Anaplastic large cell lymphoma
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Large atypical cells with pleomorphic multilobulated nuclei, abundant cytoplasm.
Immunophenotype: looks like Hodgkin lymphoma CD30+, but CD15- Pan T cell markers CD3, 5, 7 - CD2,4+ Genetics:ALK protein due to t(2:5) More favorable prognosis in people with translocation. Clinical: mostly in children, rare in adults. 15% of children lymphomas. |
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Hodgkin's lymphoma
B cell |
Reed-Sternberg cells. Connection to Epstein-Barr virus
Age: young adults and over 55. Clinical: highly curable, 90% |