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14 Cards in this Set

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Lymphomas: Hodgkin's Versus NHL: Which one presents with Reed-Sternberg cells?
Hodgkin's lymphoma (HL)
Lymphomas: Hodgkin's Versus NHL: Which one is associated with HIV and immunosuppression?
Non-Hodgkin Lymphoma (NHL)
Lymphomas: Hodgkin's Versus NHL: Which one is localized to a single group of nodes, with contagious spread and rare extranodal involvement?
HL
Lymphomas: Hodgkin's Versus NHL: Which one has hypergammaglobulinemia?
Neither. Multiple Myeloma has hypergammaglobulinemia, where the excess B cells are in the resting state.
B cell small lymphocytic lymphoma (CLL)
Morphology: predominantly small lymphocytes
Immunology. surface IgM+, CD5+, CD10-, CD 19,20,79a +, CD22+/-, CD 23+
Genetics: trisomy 12 or 13q
Clinical: leukemic, adult, indolent course
Mycosis Fungoides
and
Sezary Syndrome
Most common CUTANEOUS lymphoma.
small lymphocytes with irregular nuclear outlines
Sezary syndrome= circulating lymphoma cells
Immunophenotype: CD3, 5, 2, 4(90%)
CD8+ and CD4- (10%)
CD7- (!)
Age: 55-60
Mucosis Fungoides: 10 year survival, 97% due to slow progression
Sezary: more aggressive, 5 year survival.
Mantle cell lymphoma (MCL)
Derived from the cells of the Folicular mantle zone of lymphoid folicle.
Medium sized lymphocytes.
Immunophenotype: surface Ig+, CD19, 20, 5(!)
CD23 -
T(11:14) bcl-1 protooncogene, loss of cell cycle control
Clinical:60 y.o. Poor response to chemotherapy. Survival 18 month
Diffuse large B cell lymphoma
LARGE CELL SIZE! Most common worldwide.Can develop from low grade lymphoma (folicular). Localized to a group of lymph nodes( bone marrow involvement latter)
Immunophenotype: CD19, 20+ Can develop variety of markers, depending on development stage.
Age: 60-70 y.o., also in children, young adults.
Clinical: high proliferation rate, but sensitive to chemotherapy. 60-80% remission rate.
HIV+ patients have worse prognosis.
Follicle Center Lymphoma
Morphology: Mixture of germinal center blasts and cleaved cells.
Immunology:surface Ig+, CD19, 20,22, 79a+
CD10+/-, DC5-, BCL-2
Genetics:t(14;18) and bcl-2
Clinical: adults, indolent course, median survival of 7-9 years.
Mucosa Associated Lymphoid Tissue Lymphoma
B cell neoplasm: small, medium and large cells, round or cleaved nuclei. Looks like reactive lymphoid tissue. Associated with infections.
No CD5 and CD10
Antibiotics may induce a remission if caused by infection. Referred as marginal zone lymphoma (MZL)
Burkitt's Lymphoma
Mature B cell
"Starry sky"
Medium sized cells, basophilic cytoplasm. High mitotic rate
Immunophenotype: surface IgM+,
CD5, 23-
CD10, 19, 20, 22,79a+
Genetics: t(2:8) (8:14) (8:22)
Clinical: children, adults. Aggressive, but curable in children.
Peripheral T/NK cell lymphoma
Mature T+NK cell
Diffuse with lymph node involvement
Medium, large sized cells with atypical nuclei.
Immunophenotyping: most CD4. Variable loss of pan T cell antigens
15% of lymphomas in US.
Clinical: 60 y.o.Aggressive with frequent relapses.
3 years survival rate:40%
Anaplastic large cell lymphoma
Large atypical cells with pleomorphic multilobulated nuclei, abundant cytoplasm.
Immunophenotype: looks like Hodgkin lymphoma CD30+, but CD15-
Pan T cell markers CD3, 5, 7 -
CD2,4+
Genetics:ALK protein due to t(2:5) More favorable prognosis in people with translocation.
Clinical: mostly in children, rare in adults. 15% of children lymphomas.
Hodgkin's lymphoma
B cell
Reed-Sternberg cells. Connection to Epstein-Barr virus
Age: young adults and over 55.
Clinical: highly curable, 90%