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14 Cards in this Set
- Front
- Back
Name 4 antiplatelet drugs and their MOA
|
aspirin: inhibits CO dec. TXA2
clopidogrel: modifies ADP receptor Ticlopidine: inhibits GPIIb/IIIa expression Abciximab: binds GPIIb/IIIa |
|
Heparin MOA
lab? |
activates antithrobin III
(thus decreases thrombin and inactivates IXa-XIIa) increase PTT |
|
Heparin use
|
immediate anticoag
(pulmonary embolism, stroke, angina, MI, DVT) |
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What can you administer to reverse the heparin effects?
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protamine sulfate
(binds neg. charged heparin) |
|
Low MX heparins
(enoxaprin) (used in hip replacements) MOA advantages |
act more at Xa
longer half-life subQ administration do not have to monitor PTT |
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Warfarin MOA (an oral agent)
lab? |
interferes w/ Vit K dep modification II, VII, IX, X, Protein C and S
follow PT |
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Warfarin use
|
chronic anticoag
|
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How do you treat warfarin overdose
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IV of Vit K and fresh frozen plasma
|
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What drugs can increase the hepatic metab. of warfarin (3)
|
barbituates
glutethimide rifampin |
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what drugs can decrease the metabolism of warfarin (6)
IMPORTANT |
metronidazole
trimethoprim disulfiram cimetidine phenylbutazone sulfonamides (influenza vaccine and acute alcohol intox) |
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Heparin or warfarin, which crosses the placenta?
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warfarin
(it is teratogenic) |
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Name 4 thrombolytic agents and their use
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streptokinase
anistrepelase (ASPAC) atelplase (tPA) urokinase early MI |
|
Aminocaproic acid class
MOA |
fibrinolytic inhibitor
blocks plasmin biding to fibrinogen and fibrin |
|
Name the follwing hematopoeitic growth factors:
RBC GM-CSF C-CSF macrophage (2) |
erythropoietin
Sargamostin (recombinant) Filgrastim (recombinant) Il-3 and M-CSF |