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19 Cards in this Set
- Front
- Back
t(8;14)- gene and diseases
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t(8;14)- c-MYC/IgH
[Very fast cell proliferation] Burkitt Lymphoma (unfavorable prognosis) Mature B Cell ALL (favorable prognosis with aggressive treatment) |
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t(11;14)- gene and diseases
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t(11;14)- Cyclin D1/IgH
[Relentless slow growth] Mantle Cell Lymphoma (unfavorable prognosis) Multiple Myeloma (favorable prognosis) |
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t(14;18)- gene and disease
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t(14;18)- BCL-2/IgH
[Resistance to apoptosis] Follicular Lymphoma |
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CD19, CD20, CD5, CD38
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CD19 and CD20 (B cell markers), CD5 (T cell marker), CD38 (adverse prognosis)
indicate B-Cell CLL |
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t(4;14)- gene and disease
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t(4;14)- FGFR3/IgH
Multiple Myeloma (unfavorable prognosis) |
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t(14q32)- disease
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t(14q32)- Multiple Myeloma
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t(9;22)- gene and diseases
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t(9;22)- Philadelphia
[Poor Prognosis] All adult CML, some adult ALL, few child ALL |
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t(4;11)- disease
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t(4;11)- Infant ALL (poor prognosis)
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t(12;21)- gene and disease
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t(12;21)- TEL AML 1 (ETV-RUNX1)
Child ALL (favorable prognosis) |
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Hyperdiploid (>50 chromosomes)
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Hyperdiploid favorable in child ALL and Multiple Myeloma
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t(8;21)- gene and disease
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t(8;21)- RUNX1-RUNX1T1
[Core binding factor leukemia] [Favorable Prognosis] AML with Maturation (M2) |
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t(15;17)- gene and disease
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t(15;17)- PML-RARA
[Favorable Prognosis] Acute Promyelocytic Leukemia (M3) |
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Inv(16)- gene and disease
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Inv(16)- CBFB-MYH11
[Core binding factor leukemia] [Favorable Prognosis] AML-M4E0 (Myelomonocytic) |
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t(11q23)- gene and diseases
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t(11q23)- Myeloid Lymphoid Leukemia (MLL) Gene
[Unfavorable Prognosis] Infant, Acute Myelomonocytic (M4), and Acute Monocytic (M5) Leukemias |
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-5, -7, 5q-, 7q- disease
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-5, -7, 5q-, 7q- therapy related AML [Unfavorable Prognosis]
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t(9;11)- gene and disease
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t(9;11)- MLLT3-MLL gene
[Can partner with (t11q23)] [Intermediate Prognosis] AML |
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NMP1 mutation
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NMP1 mutation + Normal Cytogenetics in AML- favorable prognosis
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CEBPA mutation
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CEBPA mutation + Normal Cytogenetics in AML- favorable prognosis
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FLT3 mutation
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FLT3 mutation in AML- unfavorable prognosis
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