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13 Cards in this Set

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What are 2 distinctive characteristics of stem cells?
1. are highly resilient and productive, capable of continuously replenishing huge numbers of granulocytes, lymphocytes, and erythrocytes throughout life 2. represent a self-renewing population taht is able to maintain its numbers while also providing a continued supply of progenitor cells
What 2 growth factors increase platelet counts?
thrombopoietin and IL-11
What is the normal range for reticulocyte count?
0.5-1.5% OR 35,000-85,000/µL
What is the normal range for mean corpuscular volume (MCV)?
80-100
What is the normal range for neutrophils?
1800-7700/µL
What is the normal range for lymphocytes?
1100-4800/µL
What is aplastic anemia?
- an underproduction of mature blood cells - chacterized by pancytopenia with a markedly hypocellular bone marrow
What is myeloproliferative disease?
an overproduction of mature blood cells
How does myelodysplasia or acute leukemia affect the stem cell development?
both can result in failed differentiation with production of too many immature forms
Describe the symptoms of aplastic anemia?
- symptoms are related to the cytopenias 1. due to anemia: fatigue, dyspnea, or palpitation 2. due to low platelet counts: gingival bleeding, epistaxis, petechiae, or purpura 3. due to low WBC: recurrent bacterial infections
What are diagnostic criteria of severe aplastic anemia?
- in the blood, at least two of the following: 1. Neutrophil count < 500/µL 2. Platelet count < 20000/µL 3. Anemia with corrected reticulocyte count < 1% - in bone marrow, cellularity < 25%, usually < 5-10%
What are causes of aquired aplastic anemia?
- drugs - toxins - viral infection - immune disease - paroxysmal nocturnal hemoglobinuria - radiation - pregnancy
What is the treatment for aplastic anemia for patient who cannot undergo stem cell transplantation?
treatment with a combination of antithymocyte globulin (ATG) or antilymphocyte globulin (ALG) with cyclosporine (a specific T-cell inhibitor)