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10 Cards in this Set

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5 Microcytic, Hypochromic Anemias

IDA, AOI, Sideroblastic Anemia, Thallassemia, Hemoglobinopathies

Major Differentiation Test for Microcytic, Hypochromic Anemia

Iron Studies

Siderblastic (Lead) Differentiation

Basophilic Stipling, High Lead, Normal Iron

Difference Between AOI and IDA

IDA (Lack Iron Absorbtion)


AOI (Iron Trapped in the macrophages)

Major mechanism of AOI?

Hepcidin inhibits iron release, but is Acute Phase positive

Pernicious anemia (megaloblastic) caused by

Result of Anti-IF or anti-Pareital activity

Megaloblastic Anemia causes

B12 Deficiency


Folate Deficiency


Autoantibodies (Pernicious)

Early Indicators of Megaloblastic Anemia

(Methylmelonic Acid) raised in B12 deficency


Hemocysteine raised in both B12 and Folate defi

Intrinsic RBC defect treatement

Splenectomy (except Xerocytosis)


4 Types of Intrinsic RBC membrane defects

Spherocytosis (Vertical Spectrin-Ankyrin)


Elloptocytosis (Horizontal Spectrin-Ankyrin)


Stomatocytosis (Potassium pump failure)


Xerocytosis (Membrane fails to hold K+/water)