Hematology 17: Lymphoma

Front 1

lymphoma is defined by ___ (2)

Back 1

arising in lymphoid tissue
causing lymphadenopathy

Front 2

B cells which haven't undergone somatic hypermutation are in the ___ zone of the ___. these are called ___ (3).

Back 2

dark
germinal follicle
mantle cells
follicular B-blasts
centroblasts

Front 3

B cells which have undergone SHM are in the __ zone and are called ___.

Back 3

light
centrocytes

Front 4

follicular B-Blasts are in the ___ zone and when malignant give rise to ___

Back 4

dark
Burkitt's ly

Front 5

malignant centroblasts give rise to

Back 5

DLBCLy

Front 6

malignant centrocytes can give rise to ___ (3)

Back 6

follicular ly
Hodgkin's ly
DLBCLy

Front 7

main kind of indolent NHL is ___. it is hard to cure because ___. for this reason tx is ___.

Back 7

follicular ly
resistant to chemo since cells aren't replicating
deferred if asymptomatic

Front 8

aggressive NHL is curable in ___ cases. HL is curable in ___ cases.

Back 8

some
most

Front 9

NHL incidence goes up with ___. ___ may be a factor.

Back 9

age
pollution

Front 10

2 conditions associated with NHL

Back 10

connective tissue disease
immune suppression

Front 11

3 classic B symptoms

Back 11

fever
night sweats
weight loss

Front 12

2 lab findings in NHL

Back 12

elevated LDH
elevated beta 2 microglobulin

Front 13

characteristic ly immunohistochemistry findings

Back 13

Bcl2
CD20

Front 14

translocation in MCLy
this causes ___ and thus ___.

Back 14

t(11;14)
cyclin D1
acceleration of cell cycle

Front 15

stage I ly definition

Back 15

single LN area, one side of diaphragm

Front 16

stage II ly definition

Back 16

multiple LN areas, one side of diaphragm

Front 17

stage III ly definition

Back 17

multiple LN areas, above and below diaphragm

Front 18

stage IV ly definition

Back 18

multiple LN areas, above and below diaphragm, with organ mets

Front 19

if stage N ly has B cell symptoms, it's called ___, otherwise ___.

Back 19

N-B
N-A

Front 20

T/F: all lys are PET avid

Back 20

false

Front 21

life expectancy for untreated low-grade ly is ___. main example is ___. it is curable/not.

Back 21

years
follicular ly
not

Front 22

life expectancy for untreated intermediate-grade ly is ___. main example is ___. it is curable/not.

Back 22

months
DLBCLy
curable

Front 23

life expectancy for untreated high-grade ly is ___. it is curable/not

Back 23

weeks
curable

Front 24

most common ly is ___. it is the main kind of ___ ly.

Back 24

DLBCLy
intermediate-grade

Front 25

T/F: Bcl-2 accelerates cell cycle

Back 25

false: inhibits apoptosis

Front 26

translocation in follicular ly
this causes ___.

Back 26

t(14;18)
upregulation of Bcl-2

Front 27

follicular ly can transform to ___

Back 27

aggressive ly

Front 28

the only way to cure follicular ly is ___

Back 28

allogeneic SC transplant

Front 29

2 cases where FLy is treated

Back 29

advanced symptomatic disease
stage I (cure possible)

Front 30

stage I FLy pts receive

Back 30

local irradiation

Front 31

advanced symptomatic FLy pts receive ___, specifically ___ (2)

Back 31

immunochemotherapy
rituximab
chemo

Front 32

T/F: significant toxicity occurs if rituxmab eliminates all CD20 cells

Back 32

false

Front 33

T/F: DLBCLy is usually symptomatic

Back 33

true

Front 34

DLBCLy is more curable in ___ pts

Back 34

young

Front 35

DLBCLy is txed with ___ (2)

Back 35

rituximab
chemo
rads

Front 36

Hodgkin's ly originates from ___ aka ___. the characteristic cells are ___ (2).

Back 36

germinal center B cells
centrocytes
Reed-Sternberg cells
Hodgkin cells

Front 37

most cells in Hodgkin's ly LN are ___. these are non-___ cells

Back 37

reactive lymphocytes
neoplastic

Front 38

5 histological kinds of HLy

Back 38

nodular sclerosis
mixed cellularity
lymphocyte depleted
lymphocyte rich
nodular lymphocyte-predominant

Front 39

2 "most classical" variants of HLy

Back 39

nodular sclerosis
mixed cellularity

Front 40

characteristic cell in nodular sclerosis

Back 40

lacunar cell

Front 41

characteristic cell in mixed cellularity

Back 41

Reed-Sternberg cell

Front 42

characteristic cell in nodular lymphocyte-predominant

Back 42

popcorn cell

Front 43

Hly is more/less frequent than NHL

Back 43

less

Front 44

HLy incidence peaks in ___ decade and again in ___ decades

Back 44

3rd
8th-9th

Front 45

___ has been detected in 50% of HLy cases

Back 45

EBV

Front 46

3 socioeconomic factors associated with HLy

Back 46

high socioeconomic status
small family size
caucasians

Front 47

T/F: HLy commonly spreads to extranodal sites

Back 47

false

Front 48

3 long term complications of HLy tx

Back 48

infertility
secondary malignancy
cardiac disease

Front 49

chemo regimen for HLy

Back 49

ABVD