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62 Cards in this Set

  • Front
  • Back
3 parts of coagulation system
vascular wall
coagulation factors
platelets
in the first part of coagulation, vascular smooth muscle ___s, endothelial cells ___, and subendothelial ___ causes ___.
contracts
release factors III, VIII
collagen
platelet adhesion
5 platelet steps in primary hemostasis
adhesion
shape change to discoid
degranulation
recruitment
aggregation (primary hemostatic plug)
platelets use ___ to adhere to subendothelial ___
vWF
collagen
platelets use ___ to bind vWF, which is secreted by ___ (3).
GP-Ib
endothelial cells
platelets
megakaryocytes
vWF is a carrier protein for ___ and is aka ___
factor VIII
factor VIII related Ag
vWF circulates as ___ which must be ___ to be functional
multimers
large
2 kinds of platelet granules
alpha
delta
alpha granules contain
coagulation factors
delta granules are aka ___. they contain ___ (2).
dense granules
ADP
serotonin
Ca2+
platelets use the ___ complex to bind ___. this system causes ___.
GPIIb,IIIa
fibrinogen
platelet aggregation
___ serves as a binding site for factors ___ (2)
platelet factor 3
V
VIII
platelet activation includes ___ activation and ___ (2) production
PF3
thrombin
TXA2
TXA2 causes ___ (3)
vasoconstriction
platelet degranulation
platlet aggregation
aspirin inhibits synthesis of ___ (2)
TXA2
ADP
von Willebrand's disease is deficiency in ___
vWF
Glanzmann's thrombasthenia is deficiency in ___
GPIIb,IIIa
Bernard-Soulier syndrome is deficiency in ___
GPIb
factor I is ___
fibrinogen
factor II is ___
prothrombin
factor III is ___
tissue factor
factor V is ___
labile factor
___ causes hemophilia A
factor VIII
___ causes hemophilia B
factor IX
___ causes hemophilia C
factor XI
extrinsic pathway
III
VII
intrinsic pathway
XII
XI
IX
VIII
common pathway
X
V
II
I
XIII
VII activates ___ (2)
IX
X
IX activates ___
X
PT is ___ and measures ___. it is normally ___.
prothrombin time
extrinsic + common pathways
12s
4 vitamin K dependent factors
II
VII
IX
X
2 vitamin K dependent regulatory proteins
protein C
protein S
most coagulation factors are ___ proteases
Ser
during secondary hemostasis, ___ contracts
intraplatelet actomyosin
during 2' hemostasis, thrombin activates ____, which causes bridging of ___ at ____. this converts ___ to ___.
XIII
fibrin
D domains
soluble fibrin clot
stabilized fibrin clot
factor XII is activated by ___ (2)
prekallikrein
high molecular weight kininogen
3 anticoagulants produced by endothelium
2 thrombolytics produced by endothelium
PGI2
heparan sulfate
thrombomodulin
tPA
urokinase
PGI2 is aka
prostacyclin
antithrombin 3 deactivates ___ (5)
IIa
IXa
Xa
XIa
XIIa
PGI2 effects
vasodilation
conversion of ADP to anti-platelet aggregation factors
thrombin, via ___, activates ___. this serves to inactivate ___ (2).
thrombomodulin
protein C
Va
VIIIa
___ is a cofactor for protein C
protein S
heparin works by activating ___
antithrombin 3
antithrombin 3 works fast/slow
fast
warfarin works by ___
inhibiting gamma-carboxylation of vitamin K dependent factors
warfarin works fast/slow
slow (3-5 days)
urokinase is produced by ___ (2)
endothelium
monocytes
thrombolytics cause ___ (2) and inhibit ___ (3)
activation of plasminogen
cleavage of fibrin and fibrinogen
platelet aggregation
thrombin activity
fibrin cross-linking
3 products of plasmin clot degradation
D-dimers
E fragments
DED complex
vessel abnormalities have ___ bleeding time, ___ platelet count, ___ PT and ___ aPTT
normal
normal
normal
normal
hemophilia A has ___ bleeding time, ___ platelet count, ___ PT, and ___ aPTT.
normal
normal
normal
high
hemophilia A is due to ___ deficiency. a common cause is ___ but it can be inherited as ___ trait.
factor VIII
spontaneous mutation
XLR
hemophilia A is treated with ___
factor VIII, IX concentrate
hemophilia A commonly presents with ___
hemarthrosis
hemophilia B is ___ deficiency
its inheritance is ___
it is also called ___
factor IX
XLR
Christmas disease
___ is the most common hereditary coagulation disease
von Willebrand Disease
VWD has ___ bleeding time, ___ platelet count, ___ PT, and ___ aPTT.
increased
normal
normal
normal/increased
vitamin K deficiency has ___ bleeding time, ___ platelet count, ___ PT, and ___ aPTT
normal
normal
increased
normal/increased
factors synthesized in liver (6)
I
II
V
VII
IX
X
severe liver disease has ___ bleeding time, ___ platelet count, ___ PT, and ___ aPTT
normal
normal
high
high
in thrombocytopenia bleeding time is ___, PT is ___, aPTT is ___.
normal/high
normal
normal