Hematology 07: Cml

Front 1

4 myeloproliferative disorders

Back 1

polycythemia vera (PV)
essential thrombocythemia (ET)
idiopathic myelofibrosis (IMF)
chronic myeloid leukemia (CML)

Front 2

CML is caused by proliferation of ___ which gives rise to ___ (4).

Back 2

CFU_GEMM
BFU_E
CFU_Meg
CFU_GMEo
CFU_baso

Front 3

CML is caused by ___;___ translocation, aka ___.

Back 3

9
22
philadelphia chromosome

Front 4

CML presents with ___cytosis and ___philia.

Back 4

granulo
baso

Front 5

granulocytes in CML are mature/immature

Back 5

immature

Front 6

CML presents with thrombo___.

Back 6

cytosis

Front 7

CML is ___% of all leukemia with median age of diagnosis ___.

Back 7

15
55

Front 8

CML is linked with exposure to ___.

Back 8

radiation

Front 9

t(9;22) causes ___.

Back 9

Bcr/Abl chimera

Front 10

the Y kinase gene in the chimera is ___

Back 10

Abl

Front 11

t(9;22) effects include increased ___, altered ___, impaired ___, disrupted ___, and resistance to ___.

Back 11

proliferation
cytoadhesion
maturation
cell cycle regulation
apoptosis

Front 12

secondary mutations in CML can trigger ___ (2) phases

Back 12

accelerated
blast

Front 13

6 secondary mutations in CML

Back 13

monosomy 7
trisomy 8
trisomy 9
monosomy/trisomy/isochromosome 17

Front 14

CML patients are usually diagnosed in ___ phase

Back 14

chronic

Front 15

despite thrombocytosis, CML patients are prone to both ___ and ___ due to ___.

Back 15

hemorrhage
thrombosis
platelet dysfunction

Front 16

hyperleukocytosis in CML can cause ___ but is often asymptomatic

Back 16

priapism

Front 17

3 physical exam findings in CML

Back 17

splenomegaly
hepatomegaly
purpura

Front 18

as thrombocytosis in CML worsens, risk shifts to ___ and away from ___.

Back 18

hemorrhage
thrombosis

Front 19

3 lab findings in CML

Back 19

high LDH
high uric acid
low/zero LAP

Front 20

5 causes of leukocytosis

Back 20

steroids
inflammation
leukemoid reaction
severe infection
CML

Front 21

___ can distinguish CML from ___ (2)

Back 21

LAP score
MPD
leukemoid rxn

Front 22

___ is used clinically to identify philadelphia chromosome

Back 22

RT-PCR

Front 23

blast crisis is defined by ___

Back 23

>20% blasts in PB or BM

Front 24

chronic phase of CML typically lasts ___, then ___.

Back 24

3--4 years
progresses to accelerated or blast phase

Front 25

allogeneic SC transplants work best if ___ (3)

Back 25

chronic phase
soon after dx
< 40 y.o.

Front 26

3 txs for CML

Back 26

IFNa
autologous SCT
imatinib mesylate

Front 27

IFNa is sometimes given with ___

Back 27

cytarabine

Front 28

imatinib mechanism

Back 28

blocks ATP binding site on Abl

Front 29

imatinib is aka

Back 29

glivec

Front 30

tx for accelerated phase

Back 30

imatinib

Front 31

when in blast crisis, CML is treated like ___. prognosis is ___.

Back 31

acute leukemia
bad

Front 32

2 drugs for palliative CML tx

Back 32

busulfan
hydroxyurea