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20 Cards in this Set
- Front
- Back
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If a pt with osteoarthritis does not respond to systemic acetominophen (combined with non-pharm) what is the next drug of choice?
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-Topical capsaicin or methylsalicylate cream
-Consider COX 2 inhibitors -Tramadol if they have moderate to severe pain and COX 2 is contraindicated |
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What are the 4 surgical options for osteoarthritis?
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-Arthroscopic debridement
-Arthroplasty -Osteotomy -Arthodesis |
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What are the three goals of arthroplasty?
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1. Pain relief
2. Restoration of joint motion 3. Correction of structural deformities |
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Define rheumatoid arthritis
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Chronic autoimmune disease characterized by inflammation of the lining (synovium) of the joints. It can lead to long-term joint damage, resulting in chronic pain, loss of function and disability
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What role do TNF (tumor necrosing factor) and IL-1 (interluekin 1) play in rheumatoid arthritis?
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These are defense mechanisms. When they are out of balance they start to attack the bone resulting in bone loss and inflammation
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What joints does rheumatoid arthritis affect most often?
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metacarpal philange joint and proximal interphilangeal joint
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Why are NSAIDS used to treat rheumatoid arthritis?
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They inhibit prostaglandin synthesis (prostaglandins mediate pain and inflammation)
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What are the four stages of gout?
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Asymptomatic
Acute: initial painful flare up Intercritical: no symptoms Chronic: comes back |
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What is the pharmacological treatment for gout?
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*NSAIDS*
Also Colchicine, allopurinol, probenecid |
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Should a person with gout be eating high or low purine foods?
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Low
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What is the treatment for osteomyelitis?
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Start with IV antibiotics, more to surgical removal of necrotic tissue, bone graft with packing material, prosthesis removal with new prosthesis (replaced joint for example) when healed
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What is the current theory of paget's disease etiology?
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Early viral infection and dormant skeletal infection. There is an osteoclastic phase (early) with excessive bone resorption leading to bigger bone and changing formation of bone
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What role do TNF (tumor necrosing factor) and IL-1 (interluekin 1) play in rheumatoid arthritis?
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These are defense mechanisms. When they are out of balance they start to attack the bone resulting in bone loss and inflammation
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|
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What joints does rheumatoid arthritis affect most often?
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metacarpal philange joint and proximal interphilangeal joint
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Why are NSAIDS used to treat rheumatoid arthritis?
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They inhibit prostaglandin synthesis (prostaglandins mediate pain and inflammation)
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What are the four stages of gout?
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Asymptomatic
Acute: initial painful flare up Intercritical: no symptoms Chronic: comes back |
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What is the pharmacological treatment for gout?
|
*NSAIDS*
Also Colchicine, allopurinol, probenecid |
|
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Should a person with gout be eating high or low purine foods?
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Low
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What is the treatment for osteomyelitis?
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Start with IV antibiotics, more to surgical removal of necrotic tissue, bone graft with packing material, prosthesis removal with new prosthesis (replaced joint for example) when healed
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What is the current theory of paget's disease etiology?
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Early viral infection and dormant skeletal infection. There is an osteoclastic phase (early) with excessive bone resorption leading to bigger bone and changing formation of bone
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