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8 Cards in this Set
- Front
- Back
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Purpose of the HEDS I study
(herpes eye disease study) |
1. effect of topical corticosteroid on hepres simplex stromal keratitis in conjunction with triflurodine
2. effect of oral acyclovir on herpes stromal keratitis when topcial steroids and triflurodine were used 3. the efficacy of oral acyclovir in treating herpes simplex iridocyclitis in conjunction with treatment with topical corticosteroids and trifluridine. |
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What did the HEDS I study find in terms of the use of topical corticosteroids in herpetic stromal keratitis used in conjunction with triflurodine?
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faster resolution and fewer tx failures but final visual acuity was not affected at the 26 wk mark
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What happens if you add oral acyclovir to an acute case of herpetic stromal keratitis when you are already using topical cortical steroids and triflurodine?
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no apparent benefit
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What is the trend seen in adding oral acyclovir to the treatment of HSV iridocyclitis in patients receiving topical corticosteroids and trifluridine prophylaxis.
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a benefit, however, group was too small to be statistically significant
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What was the purpose of HEDS II?
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•To determine whether early treatment (with oral acyclovir) of herpes simplex virus (HSV) ulcerations of the corneal epithelium prevents progression to the blinding complications of stromal keratitis and iridocyclitis.
•To determine the efficacy of low-dose oral acyclovir in preventing recurrent HSV eye infection in patients with previous episodes of herpetic eye disease. •To determine the role of external factors (such as ultraviolet light or corneal trauma) and behavioral factors (such as life stress) on the induction of ocular recurrences of HSV eye infections and disease. |
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What did the HEDS II find out about that the rate of recurrence of herpes simplex stromal keratitis and iridocyclitits?
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the risk of stromal keratitis or iridocyclitis was quite low in the year following an episode of epithelial keratitis treated with topical trifluridine alone
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What did HEDS II find about the addition of oral acyclovir in cases of acute herpes simplex epithelial keratitis?
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the treatment of acute HSV epithelial keratitis, there was no benefit from the addition of oral acyclovir to treatment with topical trifluridine in preventing the development of stromal keratitis or iritis
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What did HEDS II find out about the rate of recurrence herpes keratitis -- all forms? And stromal keratitis in particular?
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acyclovir, taken by mouth, reduced by 41 percent the probability that any form of herpes of the eye would return in patients who had the infection in the previous year. Importantly, researchers noted a 50 percent reduction in the rate of return of the more severe form of the disease -- stromal keratitis -- among patients who had this infection during the past year
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