Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
33 Cards in this Set
- Front
- Back
NSTEMI & UA
|
MONA +GAP-BA
Morphine Oxygen Nitrates ASA/Plavix GP 2b/3a REC INH Anticoags P2Y12 INH BB ACEI/ARBs |
|
GP 2b/3a REC INH
8 CI? |
Block platelet aggregation preventing thrombosis - REC INH is the binding site for fibrinogen
Thrombocytopenia (plt <100,000/mm3) Hx of: bleed/CVA/stroke (w/in 30 days) Active internal bleed Recent surgery Renal dysfxn INC Prothrombin Time Uncontrolled sev HTN |
|
ReoPro
For? Filter? CI? 2 Primary SE? |
Abciximab - GP 2b/3a REC INH
Only admin if PCI planned Filter with administration CI - Murine pp hypersensitivity Bleeding Thrombocytopenia |
|
Integrilin
|
Eptifibatide - GP 2b/3a REC INH
CI - Renal dysfxn |
|
Aggrastat
|
Tirofiban - GP 2b/3a REC INH
CI - Renal dysfxn |
|
P2Y12 INH
|
INH platelet activation and aggregation
|
|
Plavix
For? Dose? LD if not stunting? Red effectiveness? DI? |
Clopidogrel prodrug (irreversible bind) - Only admin if PCI planned
LD: 300-600mg (600mg for PCI) MD: 75 mg QD NO loading dose if not stenting Poor met of 2C19 - RED effective 2C19 Substrate - Strong INH: PPI, Cimetidine, SSRI, Azole) |
|
Effient
For? Not REC for? |
Prasugrel - prodrug (irreversible bind) - Only admin if PCI planned
>75 - NOT REC d/t intracranial bleed |
|
Brilinta
Onset? Red effectiveness? DI? |
Ticagrelor - not prodrug (reversible bind)
Faster onset + ASA >100mg/d - RED effectiveness of Brillinta 3A4 Substrate - Strong 3A4 INH: Statin (Simva, Lova) |
|
STEMI
|
MONA + GAP - BA +/- Thrombolytics
|
|
THROMBOLYTICS
|
Fibrinolysis when bind to fibrin in a thrombus and convert entrapped plasminogen to plasmin
For: hospital can't perform PCI w/in 90 mins Initiated - w/in 30 mins (arrival to the hospital) Beneficial for STEMI - admin 12-24 hrs out from sx onset |
|
t-PA
|
Alteplase
|
|
rt-PA
|
Alteplase
|
|
Activase
|
Alteplase
|
|
r-PA
|
Reteplase
|
|
Retevase
|
Reteplase
|
|
TNK-tPA
|
Tenecteplase
|
|
TNKase
|
Tenecteplase
|
|
Streptase
|
Streptokinase
|
|
ANTICOAG
|
Prevent further clotting
|
|
UFH
|
Heparin
Treatment of ACS/STEMI: Bolus - 60 U/kg IV Infusion - 12 U/kg/hr |
|
Lovenox
|
Enoxaparin - LMWH
Treatment of UA/NSTEMI: 1 mg/kg SC Q12H or 1.5 mg/kg SC QD <30 mL/min - 1 mg/kg SC QD Treatment of STEMI (<75): Bolus - 30 mg IV + 1 mg/kg SC then 1 mg/kg SC Q12H Treatment of STEMI (>75): No Bolus - 0.75 mg/kg SC Q12H |
|
Fragmin
|
Dalteparin - LMWH
Treatment of UA/NSTEMI: 120 U/kg Q12H |
|
Innohep
|
Tinzaparin - LMWH
|
|
Arixtra
|
Fondaparinux
|
|
Refludan
|
Lepirudin - DRI (Direct Thrombin INH)
|
|
Argatroban
|
Ok - DRI
|
|
Angiomax
|
Bivalirudin - DRI
|
|
Ipravask
|
Desirudin - DRI
|
|
Pradaxa
|
Dabigatran - DRI Oral
|
|
Xarelto
|
Rivaroxaban
|
|
Coumadin
|
Warfarin
|
|
Jantoven
|
Warfarin
|