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21 Cards in this Set

  • Front
  • Back
tricyclic antidepressants are used to treat ________
major depression
How do tca's work?
block uptake of norepinephrine and serotonin
how long do TCAs take to begin working
2-4 wks
What effect do TCA's have
elevate mood, increase interest in daily living, decrease insomnia
What are some of the major SE's of TCAs
sedating, hypotension, carditoxicity
what are some of major TCAs
amitriptyline (Elavil), clomipramine (Anafranil), desipramine (Norpramin), doxipin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl), protriptyline (Vivactil), trimipramine (Surmontil)
TCA SE's
sedation, drosiness, blurred vision, dry mouth, eyes, urinary retention, constipation, wt gain, dizziness, nervousness, nausea, anoriexia, sexual dysfunction, skin issues (rash, pruritus)
How do SSRI's work?
block reuptake of serotonin into CNS. DO NOT BLOCK UPTAKE OF DOPAMINE OR NOREPINEPHERINE
primary use of SSRI's
other uses of SSRI
major depression (primary)
anxiety, OCD, panic, phobia, PTSD, eating disorders, drug abuse, PMS
Names of SSRIs
fluoxetine (Prozac), fluvoxamine (Luvox)
sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro)
Many SSRIs have interaction with ________ that can lead to possible toxicity
grapefruit juice
SE Prozac
dry mouth, blurred vision, insomnia, HA, nervousness, anorexia, nausea, diarrhea, suicidal ideation
atypical antidepressants are used for ___________
major depression, reactive depression, anxiety
how do atypical antidepressants work
they affect one or two of the three neurotransmitters serotonin, norepinephrine, and dopamine
list atypical antidepressants
amoxapine (Asendin)
bupropion (wellbutrin)
maprotiline (Ludiomil)
nefazodone (Serzone)
trazodone (Desyrel)
mirtazapine (Remeron)
venlafaxine (Effexor)
reboxetine (Vestra)
How do MAOIs work
ezzyme monoamine oxidase inactivates norepinephrine, dopamine, epinepherine, serotonin. By inhibiting MO, levels of these neurotransmitters rise
where are MAO-A and MAO-B found in the body
liver and braion
What does MAO-A inactivate
dopamine
what does MAO-B inactivate
norepinephrine and serotonin
what are the three MAOIs that are prescribed
Tranylcypromine sulfate (Parnate), isocarboxazid (Marplan), and phenelzine sulfate (Nardil)
what is the major risk of MAOIs?
hypertensive crisis resulting from food and drug interactions